Pyogenic granuloma-like reaction in the necrotic, vessels-deprived femoral head of the rat.

abstract：BACKGROUND:Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers totally la...

journal_title：Experimental and molecular pathology

authors： Nottegar A,Tabbò F,Luchini C,Guerrera F,Gaudiano M,Bria E,Brunelli M,Chilosi M,Inghirami G

更新日期：2017-04-01 00:00:00

abstract：:Previous studies demonstrated that more electronegative low density lipoprotein (LDL) isolated from human blood by ion exchange chromatography has a chemical composition and physical properties similar to desialylated LDL obtained by lectin chromatography (Avogaro et al., 1988; Orekhov et al., 1989). In this study, si...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Bittolo-Bon G,Sobenin IA,Cazzolato G,Orekhov AN,Avogaro P

更新日期：1995-06-01 00:00:00

abstract：:Mast cells play a key role in immunoglobulin E (IgE)-associated allergic disorders; however, the cellular effects of sensitization remain poorly understood. Using gene microarrays and the multiplexing ELISA method, we examined the effects of sensitization on RBL-CCR1 cell transcription and chemokine/cytokine secretion...

journal_title：Experimental and molecular pathology

authors： Kuo CH,Morohoshi K,Aye CC,Garoon RB,Collins A,Ono SJ

更新日期：2012-12-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung...

journal_title：Experimental and molecular pathology

authors： Chen X,Shi C,Meng X,Zhang K,Li X,Wang C,Xiang Z,Hu K,Han X

更新日期：2016-08-01 00:00:00

abstract：:Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with ...

journal_title：Experimental and molecular pathology

authors： Karrasch T,Brünnler T,Hamer OW,Schmid K,Voelk M,Herfarth H,Buechler C

更新日期：2015-10-01 00:00:00

abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

journal_title：Experimental and molecular pathology

authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

更新日期：2008-10-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefo...

journal_title：Experimental and molecular pathology

authors： de A Simão T,Souza-Santos PT,de Oliveira DS,Bernardo V,Lima SC,Rapozo DC,Kruel CD,Faria PA,Ribeiro Pinto LF,Albano RM

更新日期：2011-10-01 00:00:00

abstract：:Abnormalities in several signaling pathways and in the expression and/or activation of different transcription factors in psoriatic keratinocytes have been hypothesized to play a role in the pathophysiology of psoriasis. The mitogen-activated protein kinase (MAPK) cascades are among the best characterized of intracell...

journal_title：Experimental and molecular pathology

authors： Yu XJ,Li CY,Dai HY,Cai DX,Wang KY,Xu YH,Chen LM,Zhou CL

更新日期：2007-12-01 00:00:00

abstract：:Recent research has shown that oncogenic human papillomavirus (HPV) DNA, which is currently used in the screening and diagnosis of cervical cancer, can be detected not only in high-grade cervical lesions, but also in low-grade cervical lesions and normal tissues. For this reason, HPV tests targeting the E6 and E7 mRNA...

journal_title：Experimental and molecular pathology

authors： Munkhdelger J,Kim G,Wang HY,Lee D,Kim S,Choi Y,Choi E,Park S,Jin H,Park KH,Lee H

更新日期：2014-10-01 00:00:00

abstract：:TNF-alpha is a proinflammatory cytokine, abundantly expressed after myocardial infarction. It has been suggested that it exhibits myocardial suppressive and cytotoxic effects. AG-556 is a tyrosine kinase inhibitor synthesized based on its ability to reduce TNF-alpha production and cell toxicity, and to improve experim...

journal_title：Experimental and molecular pathology

authors： George J,Biner S,Keren P,Barshack I,Goldberg I,Sherez J,Levitzki A,Keren G,Roth A

更新日期：2003-06-01 00:00:00

abstract：:It is well-known that leukemic cells of overt leukemia (OL) that have transformed from myelodysplastic syndromes (MDS) are more resistant to chemotherapy as compared with de novo AML cells. Thus, to examine the expression levels of drug-resistant genes and their alterations with the development of OL in MDS, the expre...

journal_title：Experimental and molecular pathology

authors： Kurata M,Hasegawa M,Nakagawa Y,Abe S,Yamamoto K,Suzuki K,Kitagawa M

更新日期：2006-12-01 00:00:00

abstract：:RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. Binding of the monoclonal antibody (MAb) RAK-BrI to cancer RAK antigens has been found to be inhib...

journal_title：Experimental and molecular pathology

authors： Kyriacou KC,Iacovou F,Adamou A,Hadjisavvas A,Rakowicz-Szulczynska EM

更新日期：2000-08-01 00:00:00

abstract：:The aim of this study was to evaluate if polymorphisms of APLN and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients. A case-control study was carried out including normotensive and hypertensive individuals. For these, two polymorphisms of APLN (rs3761581 and...

journal_title：Experimental and molecular pathology

authors： Esteban-Martínez RL,Pérez-Razo JC,Vargas-Alarcón G,Martínez-Rodríguez N,Cano-Martínez LJ,López-Hernández LB,Rojano-Mejía D,Canto P,Coral-Vazquez RM

更新日期：2016-08-01 00:00:00

abstract：:Purified bovine cardiac G-actin was interacted with doxorubicin (Adriamycin, ADR), in absence of potassium or magnesium to study ADR's effects on actin polymerization. Actin with ADR (10(-6) M) was incubated with polylysine-coated polystyrene beads and filaments formed were visualized by negative staining electron mic...

journal_title：Experimental and molecular pathology

authors： Mariano R,Gonzalez B,Lewis W

更新日期：1986-02-01 00:00:00

abstract：:The extracellular localizations of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) were examined in cultured bovine capillary endothelial cells (BCEs) by an immunofluorescence method using BCEs treated with or without saponin and focal ...

journal_title：Experimental and molecular pathology

authors： Murata T,Nakashima Y,Yasunaga C,Maeda K,Sueishi K

更新日期：1991-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

journal_title：Experimental and molecular pathology

authors： Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

更新日期：2020-06-01 00:00:00

abstract：:Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Elzer PH,Wu X

更新日期：2012-08-01 00:00:00

abstract：:SNAIL, a potent repressor of E-cadherin expression, plays a key role in inducing epithelial-to-mesenchymal transition (EMT) in epithelial cells. During EMT, epithelial cells lose cell polarity and adhesion, and undergo drastic morphological changes acquiring highly migratory abilities. Although there is increasing evi...

journal_title：Experimental and molecular pathology

authors： Nishioka R,Itoh S,Gui T,Gai Z,Oikawa K,Kawai M,Tani M,Yamaue H,Muragaki Y

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:DNA methylation is the most important epigenetic change involved in the control of gene expression in human cells. Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs) are prevalent, and their behavior is variable. OBJECTIV...

journal_title：Experimental and molecular pathology

authors： Silveira FA,Almeida G,Furtado Y,Silva KS,Maldonado P,Cavalcanti S,Carvalho Mda G

更新日期：2015-04-01 00:00:00

abstract：:Retinoblastoma (RB), the most common intra-ocular malignancy in children under 5 years of age, has an estimated incidence of about 2000 a year in India, where most cases are in advanced stage at the time of diagnosis. Newer therapeutic approaches would reduce the morbidity of chemotherapy in children with RB. Fatty Ac...

journal_title：Experimental and molecular pathology

authors： Vandhana S,Deepa PR,Jayanthi U,Biswas J,Krishnakumar S

更新日期：2011-02-01 00:00:00

abstract：:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contain...

journal_title：Experimental and molecular pathology

authors： Müller RM,Roomans GM

更新日期：1984-12-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family. We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells. CP-like lesions are characterized by acinar and ductal-ductular cell p...

journal_title：Experimental and molecular pathology

authors： Naito Z,Ishiwata T,Lu YP,Teduka K,Fujii T,Kawahara K,Sugisaki Y

更新日期：2003-02-01 00:00:00

abstract：:The pathophysiological biology of human hypertrophic scar was examined in a long-term organ culture system. Fresh full-thickness, thin slices of scar were placed in petri dishes. Tissue was successfully maintained for 2 weeks in an environment made up of CMRL-1066 medium, fetal bovine serum, insulin, and hydrocortison...

journal_title：Experimental and molecular pathology

authors： Ehrlich HP,Buttle DJ

更新日期：1984-04-01 00:00:00

abstract：:We have produced experimental diffuse interstitial pulmonary fibrosis in rats with a combination of low and repeated doses of paraquat plus continuous exposure to normobaric 74% O2 in the breathing air for several weeks. Pulmonary fibrosis was evaluated histologically and biochemically, through the determination of to...

journal_title：Experimental and molecular pathology

authors： Selman M,Montaño M,Montfort I,Pérez-Tamayo R

更新日期：1985-12-01 00:00:00

abstract：:The hamster cheek pouch is an excellent target tissue for the experimental study of oral carcinogenesis. In the course of searching for molecular alterations during the malignant transformation process, the necessity for a molecular marker for cellular proliferation became apparent. In this report, we show that the ce...

journal_title：Experimental and molecular pathology

authors： Wong DT

更新日期：1988-10-01 00:00:00

abstract：:Oral cancer is a major health problem in many parts of the world including India. The molecular mechanisms involved in oral tumorigenesis are not completely understood. Although surgery continues to be the most common treatment modality for this cancer, survival rates of oral cancer patients have still not significant...

journal_title：Experimental and molecular pathology

authors： Santhi WS,Sebastian P,Varghese BT,Prakash O,Pillai MR

更新日期：2006-10-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice bu...

journal_title：Experimental and molecular pathology

authors： Brychtova V,Zampachova V,Hrstka R,Fabian P,Novak J,Hermanova M,Vojtesek B

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. AIMS:To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral ca...

journal_title：Experimental and molecular pathology

authors： de Faria PR,Chammas R,de Melo TL,Hsu DK,Liu FT,Nonogaki S,Cardoso SV,Loyola AM

更新日期：2011-04-01 00:00:00

abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

journal_title：Experimental and molecular pathology

authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

更新日期：2003-08-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties. Its pathogenesis is at least partially mediated by immunological factors, including a possible autoimmune response. To date, only a few antibodies have been identified in sera from patients with AMD. In order ...

journal_title：Experimental and molecular pathology

authors： Morohoshi K,Patel N,Ohbayashi M,Chong V,Grossniklaus HE,Bird AC,Ono SJ

更新日期：2012-02-01 00:00:00