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Pulmonary adenocarcinoma with enteric differentiation: Dissecting oncogenic genes alterations with DNA sequencing and FISH analysis.

Abstract：

BACKGROUND:Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers totally lack. METHODS:We examined the NRAS, PIK3CA, EGFR, KRAS and BRAF status through mass spectrometry sequencing and ALK rearrangement by FISH in a series of 8 PAEDs. RESULTS:1/8 (12.5%) case had a simultaneous PIK3CA mutation (E545K) and an EML4-ALK translocation. KRAS gene showed a mutation in the codon 12 in 4/8 of PAED (50%), NRAS, BRAF and EGFR genes were wild type in all tumor samples. CONCLUSIONS:We concluded that PIK3CA mutations and ALK rearrangement occur also in PAEDs, while NRAS mutations might be a very rare event similarly to pulmonary adenocarcinomas of conventional type. KRAS is the prevailing gene mutated in this class of adenocarcinoma.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Nottegar A,Tabbò F,Luchini C,Guerrera F,Gaudiano M,Bria E,Brunelli M,Chilosi M,Inghirami G

doi

10.1016/j.yexmp.2017.02.014

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

276-279

issue

2

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(16)30369-0

journal_volume

102

pub_type

杂志文章

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