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The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.

Abstract：

:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins could prevent AD. We compared the literature on MDBs and AD pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90, 104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including the 26s proteasome, the IPOD and JUNQ and autophagosome pathways.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

French SW,Mendoza AS,Peng Y

doi

10.1016/j.yexmp.2016.03.010

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

426-33

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(16)30028-4

journal_volume

100

pub_type

杂志文章,评审

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