The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma.

abstract：:To study the effects of homocysteine on epithelial and stromal tissues, the free base of homocysteine thiolactone was synthesized and administered to mice. Intraperitoneal and intramuscular doses of 0.2 to 2.0 mg/g are acutely toxic, causing as much as 90% mortality because of intense tissue necrosis at the injection ...

journal_title：Experimental and molecular pathology

authors： McCully KS,Vezeridis MP

更新日期：1989-10-01 00:00:00

abstract：:Selected estimates of lipid peroxidation were analyzed in mouse quadriceps femoris muscle immediately after submaximal prolonged (9 hr) and exhaustive maximal running (2-3 hr), and at intervals 1-10 days afterward during the exercise-induced myopathy. Immediately after the two types of exertion no significant changes ...

journal_title：Experimental and molecular pathology

authors： Salminen A,Vihko V

更新日期：1983-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

journal_title：Experimental and molecular pathology

authors： Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

更新日期：2020-06-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung...

journal_title：Experimental and molecular pathology

authors： Chen X,Shi C,Meng X,Zhang K,Li X,Wang C,Xiang Z,Hu K,Han X

更新日期：2016-08-01 00:00:00

abstract：:This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic ste...

journal_title：Experimental and molecular pathology

authors： Neuman MG,French SW,French BA,Seitz HK,Cohen LB,Mueller S,Osna NA,Kharbanda KK,Seth D,Bautista A,Thompson KJ,McKillop IH,Kirpich IA,McClain CJ,Bataller R,Nanau RM,Voiculescu M,Opris M,Shen H,Tillman B,Li J,Liu H

更新日期：2014-12-01 00:00:00

abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

journal_title：Experimental and molecular pathology

authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

更新日期：1997-01-01 00:00:00

abstract：:Rats were exposed to 12% O2 (1 atm) for 48 hr, then 10% O2 for the duration of the exposures. Significant elevations in enzymes of the glutathione peroxidase system were found in the lungs of rats killed 3.5, 7.5, and 12.5 days of exposure compared to air-breathing controls. Superoxide dismutase was also elevated afte...

journal_title：Experimental and molecular pathology

authors： Reddy AK,Kimball RE,Omaye ST

更新日期：1986-12-01 00:00:00

abstract：:Uveitis is an inflammation of the uveal tract and is one of the major causes of visual impairment. Several lines of evidence suggest an important role for activated T lymphocytes in the perpetuation of posterior uveitis. In sequel to our preliminary observations with human S-antigen, we have further investigated the p...

journal_title：Experimental and molecular pathology

authors： Tripathi P,Saxena S,Yadav VS,Naik S,Singh VK

更新日期：2004-04-01 00:00:00

abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

journal_title：Experimental and molecular pathology

authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

更新日期：1998-10-01 00:00:00

abstract：:Antigen-specific CD8 suppressor T cells (CD8(+) Ts) are adaptive regulatory T cells that are induced in vivo and in vitro by chronic antigenic stimulation of human T cells. CD8(+) Ts induce the upregulation of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells rendering these antigen presenting ce...

journal_title：Experimental and molecular pathology

authors： Vlad G,Suciu-Foca N

更新日期：2012-12-01 00:00:00

abstract：:The components of the insulin-like growth factor (IGF) system and molecules with which they interact are associated with the neoplastic transformation of cells in colorectal cancer. The IGF-binding protein-2 (IGFBP-2) plays a significant role in mitotic stimulation of the cancer cells and its concentration is signific...

journal_title：Experimental and molecular pathology

authors： Šunderić M,Đukanović B,Malenković V,Nedić O

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Ethanol has been considered as a lifestyle risk factor for cancer in humans. While some studies have indicated that alcohol intake has a preventive effect for renal cell cancer, others have not. The metabolism of alcohol in cancer cells may be in many ways different than in healthy tissue and its disturbance...

journal_title：Experimental and molecular pathology

authors： Orywal K,Jelski W,Werel T,Szmitkowski M

更新日期：2015-06-01 00:00:00

abstract：:The present study was addressed to understand two specific issues: (a) whether atherogenic activity of smooth muscle cells could be initiated by incorporating cholesterol within their membranes through a LDL-receptor-independent pathway; and (b) whether trifluoperazine, which we had recently shown to prevent the chole...

journal_title：Experimental and molecular pathology

authors： Mehta U,Kaul D

更新日期：1991-08-01 00:00:00

abstract：:Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been shown to ameliorate the clinical signs of EAE by suppressing the productio...

journal_title：Experimental and molecular pathology

authors： Liu N,Kan QC,Zhang XJ,Xv YM,Zhang S,Zhang GX,Zhu L

更新日期：2014-12-01 00:00:00

abstract：:Male Wistar rats were administered daily intraperitoneal injections of 125, 250, 500, and 1000 mg/kg/day of vitamin B6 for 2 and 6 weeks and the histogenesis of the testicular damage was investigated. A reduction of germ cells was not prominent in the 2-week groups, whereas a delay in spermiation, degeneration of elon...

journal_title：Experimental and molecular pathology

authors： Kaido M,Mori K,Ide Y,Inoue N,Koide O

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

journal_title：Experimental and molecular pathology

authors： Chen P,Yan H,Chen Y,He Z

更新日期：2009-04-01 00:00:00

abstract：:As a first step in studies on the molecular mechanism(s) underlying gentamicin toxicity, the effect of treating rats with this aminoglycoside antibiotic (100 mg/kg once or twice daily for 3 days) on the analytical subfractionation of the kidney cortex has been examined. DNA was used as a marker for the nuclei, cytochr...

journal_title：Experimental and molecular pathology

authors： Nässberger L,Bergstrand A,DePierre JW

更新日期：1987-04-01 00:00:00

abstract：:The proteasome interacts with a large number of proteins which regulate specific cellular functions. The focus of this study is to examine the proteasome interaction with Delta-aminolevulinate dehydratase (ALAD). ALAD is involved in the heme biosynthesis pathway and was co-isolated, with the 20S proteasome using sever...

journal_title：Experimental and molecular pathology

authors： Bardag-Gorce F,French SW

更新日期：2011-10-01 00:00:00

abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

journal_title：Experimental and molecular pathology

authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

更新日期：2001-02-01 00:00:00

abstract：:Bezafibrate and clofibrate reduce the quantity of esterified cholesterol, decrease the incorporation of 14C-labeled oleic acid into cholesterol ester and inhibit acyl coenzyme A cholesterol acyltransferase activity in rabbit peritoneal macrophages stimulated with acetylated low density lipoprotein. In all cases, the e...

journal_title：Experimental and molecular pathology

authors： Hudson K,Mojumder S,Day AJ

更新日期：1983-02-01 00:00:00

abstract：:Sabaeksan has been used for prevention and treatment of bronchial asthma and allergic asthma in Korea. To investigate the biological effect of Sabaeksan, we examined the effect of Sabaeksan on the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-induced pro-inflammatory cytokines secretion in human m...

journal_title：Experimental and molecular pathology

authors： Choi IY,Koo HN,Lee SH,Shin JY,Chae HJ,Kim HR,Kim CH,Hong SH,Kim HM

更新日期：2005-06-01 00:00:00

abstract：:Ten cases of myopathy caused by glycogen storage diseases of type II, III, and V, and phosphorylase b kinase deficiency are reported. So-called "abnormal lysosomes" or glycogenosomes which contain abundant glycogen were found in cases of type II, and in some numbers, in cases of type III, and in one case of phosphoryl...

journal_title：Experimental and molecular pathology

authors： Iwamasa T,Fukuda S,Tokumitsu S,Ninomiya N,Matsuda I,Osame M

更新日期：1983-06-01 00:00:00

abstract：:Deletion in the 22.9 -Mb chromosomal (chr.) 8p21.3-23 region has been shown to be necessary for the development of breast carcinoma (CaBr). In this study, we have attempted to detect the minimal deleted region(s) in the chr.8p21.3-23 region in 62 primary breast lesions having 56 CaBr tumors and six other breast lesion...

journal_title：Experimental and molecular pathology

authors： Bhattacharya N,Chunder N,Basu D,Roy A,Mandal S,Majumder J,Roychowdhury S,Panda CK

更新日期：2004-06-01 00:00:00

abstract：:The morphology of Gleason 4 prostate cancer (PCa) can be subdivided into cribriform and non-cribriform patterns. A large body of evidence has shown that pattern 4 cribriform PCa (especially non-glomeruloid type) is associated with adverse pathologic features and clinical outcomes compared with non-cribriform pattern 4...

journal_title：Experimental and molecular pathology

authors： Xiao GQ,Nguyen E,Unger PD,Sherrod AE

更新日期：2020-06-01 00:00:00

abstract：:A large surgical wound is required for implantation of silicone mammary devices. Formation of capsules around silicone devices follows wound healing processes except that the healing is conformed and significantly delayed by the physical presence of the implant. Multilayered capsules are thicker and lymphocytic and pl...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Smalley DL

更新日期：1999-09-01 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Dash S,Garry RF

更新日期：2004-08-01 00:00:00

abstract：:Although the extraction and analysis of nucleic acids from formalin-fixed paraffin-embedded tissues is a routine and growing part of pathology practice, no generally accepted recommendations exist to guide laboratories in their selection of tissue fixation, processing and DNA/RNA extraction techniques. The aim of this...

journal_title：Experimental and molecular pathology

authors： Turashvili G,Yang W,McKinney S,Kalloger S,Gale N,Ng Y,Chow K,Bell L,Lorette J,Carrier M,Luk M,Aparicio S,Huntsman D,Yip S

更新日期：2012-02-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

journal_title：Experimental and molecular pathology

authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

更新日期：2016-04-01 00:00:00

abstract：:As the number of elderly patients increases, some patients with heart problems may also need surgery. The purpose of this study was to investigate whether dexmedetomidine (DEX), a common used anesthetic, was beneficial to the patients with heart problems. Myocardial cells induced by doxorubicin (DOX) was to simulate t...

journal_title：Experimental and molecular pathology

authors： He Y,Yang Z,Li J,Li E

更新日期：2020-04-01 00:00:00

abstract：:One of the models that best explains the cellular heterogeneity observed in central nervous system (CNS) tumors is the presence of cancer stem cells (CSCs). CSCs can originate from differentiated adult cells that return to an undifferentiated stage through the mechanism known as epithelial-mesenchymal transition (EMT)...

journal_title：Experimental and molecular pathology

authors： Gonçalves BÔP,Fialho SL,Silvestrini BR,Sena IFG,Dos Santos GSP,Assis Gomes D,Silva LM

更新日期：2020-10-01 00:00:00