Anti-inflammatory activity of Korean folk medicine 'Sabaeksan'.

abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Dash S,Garry RF

更新日期：2004-08-01 00:00:00

abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...

journal_title：Experimental and molecular pathology

authors： McNulty SN,Schwetye K,Goldstein M,Carter J,Schmidt RE,Ansstas G,Tsien CI,Kim AH,Dahiya S

更新日期：2018-12-01 00:00:00

abstract：:Chemerin is a recently described adipokine whose adipose tissue and serum levels are increased in obesity. Chemerin is expressed in the liver, and here, expression of chemerin has been studied in liver cells and in non-alcoholic fatty liver disease (NAFLD) which is more often found in obesity. Chemerin is shown to be ...

journal_title：Experimental and molecular pathology

authors： Krautbauer S,Wanninger J,Eisinger K,Hader Y,Beck M,Kopp A,Schmid A,Weiss TS,Dorn C,Buechler C

更新日期：2013-10-01 00:00:00

abstract：:The thrombocyte is the avian equivalent of the mammalian blood platelet and is involved in hemostasis through a fibrinogen-mediated process. Although fibrinogen has been implicated as a molecular bridge between activated cells during aggregation, the location of this molecule and its receptor on thrombocytes has not b...

journal_title：Experimental and molecular pathology

authors： O'Toole ET,Hantgan RR,Lewis JC

更新日期：1994-12-01 00:00:00

abstract：:The effect of dichlorvos exposure (5 mg kg-1 body wt, ip) on lipid peroxidation and antioxidant defense system in different regions of the rat central nervous system was studied. In the present paper an inhibition of acetylcholinesterase activity was used as an index of dichlorvos neurotoxicity. We observed significan...

journal_title：Experimental and molecular pathology

authors： Julka D,Pal R,Gill KD

更新日期：1992-04-01 00:00:00

abstract：:The extracellular localizations of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) were examined in cultured bovine capillary endothelial cells (BCEs) by an immunofluorescence method using BCEs treated with or without saponin and focal ...

journal_title：Experimental and molecular pathology

authors： Murata T,Nakashima Y,Yasunaga C,Maeda K,Sueishi K

更新日期：1991-10-01 00:00:00

abstract：:Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

journal_title：Experimental and molecular pathology

authors： Winocour PD,Hryhorenko L

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid. METH...

journal_title：Experimental and molecular pathology

authors： Ahmad F,Nathani R,Venkat J,Bharda A,Vanere V,Bhatia S,Das BR

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers totally la...

journal_title：Experimental and molecular pathology

authors： Nottegar A,Tabbò F,Luchini C,Guerrera F,Gaudiano M,Bria E,Brunelli M,Chilosi M,Inghirami G

更新日期：2017-04-01 00:00:00

abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

journal_title：Experimental and molecular pathology

authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

更新日期：2008-10-01 00:00:00

abstract：:miR-126 has been implicated in the processes of inflammation and angiogenesis. Through these processes, miR-126 is implicated in cancer biology, but its role there has not been well reviewed. The aim of this review is to examine the molecular mechanisms and clinicopathological significance of miR-126 in human cancers....

journal_title：Experimental and molecular pathology

authors： Ebrahimi F,Gopalan V,Smith RA,Lam AK

更新日期：2014-02-01 00:00:00

abstract：:The CXC chemokine receptor CXCR4 was the first molecule identified as a coreceptor working in conjunction with CD4 to mediate cellular entry for the human immunodeficiency virus (HIV-1). Since that original discovery, 11 other seven-mtransmembrane domain molecules, many of which are chemokine receptors, have been show...

journal_title：Experimental and molecular pathology

authors： van der Meer P,Ulrich AM,Gonźalez-Scarano F,Lavi E

更新日期：2000-12-01 00:00:00

abstract：:The MHB-2 cell line, established from a mouse hepatoblastoma (HB), was subjected to the reverse transcriptase-polymerase chain reaction (RT-PCR) for evaluation of gene expression related to cell differentiation. RNAs for c-kit, CD34, thy-1, albumin, cytokeratin (CK) 8, 18 and 19 could be detected, but expression of al...

journal_title：Experimental and molecular pathology

authors： Sakairi T,Okada M,Ikeda I,Utsumi H,Kohge S,Sugimoto J,Sano F,Takagi S

更新日期：2007-12-01 00:00:00

abstract：:The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of st...

journal_title：Experimental and molecular pathology

authors： Oren A,Ganz T,Liu L,Meerloo T

更新日期：2003-04-01 00:00:00

abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

journal_title：Experimental and molecular pathology

authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

更新日期：2011-02-01 00:00:00

abstract：:As the number of elderly patients increases, some patients with heart problems may also need surgery. The purpose of this study was to investigate whether dexmedetomidine (DEX), a common used anesthetic, was beneficial to the patients with heart problems. Myocardial cells induced by doxorubicin (DOX) was to simulate t...

journal_title：Experimental and molecular pathology

authors： He Y,Yang Z,Li J,Li E

更新日期：2020-04-01 00:00:00

abstract：:A dramatic increase in the plasma glucagon/insulin ratio can be induced by treating fasted rats with antilipolytic drugs (e.g., with 3,5-dimethylpyrazole, 12 mg/kg body wt). These hormone changes are the physiologically appropriate response to a rapid decrease in free fatty acids and glucose plasma levels. Under this ...

journal_title：Experimental and molecular pathology

authors： Bergamini E,De Tata V,Cubeddu TL,Masiello P,Pollera M

更新日期：1987-02-01 00:00:00

abstract：:Selected estimates of lipid peroxidation were analyzed in mouse quadriceps femoris muscle immediately after submaximal prolonged (9 hr) and exhaustive maximal running (2-3 hr), and at intervals 1-10 days afterward during the exercise-induced myopathy. Immediately after the two types of exertion no significant changes ...

journal_title：Experimental and molecular pathology

authors： Salminen A,Vihko V

更新日期：1983-06-01 00:00:00

abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

journal_title：Experimental and molecular pathology

authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

更新日期：2003-08-01 00:00:00

abstract：:The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

journal_title：Experimental and molecular pathology

authors： Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

更新日期：1985-04-01 00:00:00

abstract：:We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in...

journal_title：Experimental and molecular pathology

authors： Asa PB,Wilson RB,Garry RF

更新日期：2002-08-01 00:00:00

abstract：:The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

journal_title：Experimental and molecular pathology

authors： Donoff RB,Swann DA,Schweidt SH

更新日期：1984-02-01 00:00:00

abstract：:Increased levels of prolactin (PRL) have recently been associated with carcinogenesis and the exacerbation of autoimmune diseases, and might be involved in the progression of tuberculosis (TB). To investigate the relationship between PRL and prolactin receptor (PRLr) expression with inflammatory response and apoptosis...

journal_title：Experimental and molecular pathology

authors： López-Rincón G,Mancilla R,Pereira-Suárez AL,Martínez-Neri PA,Ochoa-Zarzosa A,Muñoz-Valle JF,Estrada-Chávez C

更新日期：2015-06-01 00:00:00

abstract：:Changes in lung structure and collagen metabolism were studied at 1, 2, 3, 4, 6, and 8 weeks in a model of pulmonary fibrosis induced in rats with paraquat plus hyperoxia. Morphologic examination of the lungs revealed that the earliest lesions consisted of severe and irreversible endothelial and alveolar epithelial ce...

journal_title：Experimental and molecular pathology

authors： Selman M,Montaño M,Ramos C,Barrios R,Pérez-Tamayo R

更新日期：1989-04-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholam...

journal_title：Experimental and molecular pathology

authors： Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

更新日期：1984-12-01 00:00:00

abstract：:Recent insights have implicated mesothelial-to-mesenchymal transition (MMT) as a mechanism by which mesothelial cells can transdifferentiate into cancer-associated fibroblasts (CAFs) in several cancers metastasizing to the peritoneum. However, this was not evaluated extensively in colorectal cancer. We examined the pr...

journal_title：Experimental and molecular pathology

authors： Demuytere J,Ceelen W,Van Dorpe J,Hoorens A

更新日期：2020-08-01 00:00:00

abstract：:Severe sepsis remains an important cause of death, particularly among trauma and burn patients. The severity of the systemic inflammatory response after trauma or burns and susceptibility to sepsis vary among individuals. One possible mechanism is through differential effects on glucocorticoid receptor (GR) expression...

journal_title：Experimental and molecular pathology

authors： Yee KS,Cho K,Green T,Chandler J,Greenhalgh DG

更新日期：2008-06-01 00:00:00

abstract：:Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell...

journal_title：Experimental and molecular pathology

authors： Madge LA,Pober JS

更新日期：2001-06-01 00:00:00

abstract：:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins cou...

journal_title：Experimental and molecular pathology

authors： French SW,Mendoza AS,Peng Y

更新日期：2016-06-01 00:00:00