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Adrenergic activity as a modulating factor in the genesis of myocardial hypertrophy in the rat.

Abstract：

:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholamines (i.e., isoproterenol) and endogenous catecholamines (released from tyramine) are able to bring about a degree of myocardial hypertrophy associated with a significant increase in the ventricular concentrations of hydroxyproline, without affecting hemodynamic parameters (blood pressures and heart rate). Thus the modulation of sympathetic tone in the genesis of cardiac hypertrophy is demonstrated, and a direct effect of the catecholamines on cardiac cells is postulated which is independent of hemodynamic changes.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

doi

10.1016/0014-4800(84)90028-5

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

390-6

issue

3

eissn

0014-4800

issn

1096-0945

pii

0014-4800(84)90028-5

journal_volume

41

pub_type

杂志文章

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