当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma.

Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma.

Abstract：

:CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal antibody. Sixty-five of 67 papillary carcinomas (97%) strongly expressed CD44 with an intense plasma membrane pattern. Thirty-seven of these cases originated from Albany, New York, and 30 cases from Russia. Immunoreactivity was also observed in 9 of 16 follicular adenomas (56%); 4 of 8 Hurthle cell neoplasms (50%); 5 of 15 medullary carcinomas (33%); and 3 of 8 follicular carcinomas (38%). These results show that among thyroid neoplasms, papillary carcinomas preferentially display the CD44 antigen (P < or = 0.001). Nonneoplastic follicular epithelium exhibited a low to moderate level of staining. To further characterize the CD44 isoform, we tested a subset of cases with the 2F10 anti-human CD44 variant 6 monoclonal antibody, which recognizes a CD44 variant exon (CD44v6) implicated in tumor metastasis. Eleven of 11 papillary carcinomas tested were 2F10 positive, and 1 of the follicular carcinomas was positive. These results suggest the hypothesis that deregulated CD44v6 expression on the plasma membrane of papillary carcinoma cells contributes to the ability of those cells to metastasize to regional lymph nodes and then to remain dormant for years. Our results suggest that human papillary thyroid cancer will be an interesting model in which to further study the role of CD44 isoforms, particularly those containing CD44v6, in tumor metastasis and lymphatic invasion.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Figge J,del Rosario AD,Gerasimov G,Dedov I,Bronstein M,Troshina K,Alexandrova G,Kallakury BV,Bui HX,Bratslavsky G

doi

10.1006/exmp.1994.1037

subject

Has Abstract,Author List Incomplete

pub_date

1994-12-01 00:00:00

pages

203-11

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014480084710379

journal_volume

61

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Lipid peroxidation in exercise myopathy.

    abstract：:Selected estimates of lipid peroxidation were analyzed in mouse quadriceps femoris muscle immediately after submaximal prolonged (9 hr) and exhaustive maximal running (2-3 hr), and at intervals 1-10 days afterward during the exercise-induced myopathy. Immediately after the two types of exertion no significant changes ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(83)90077-1

    authors： Salminen A,Vihko V

    更新日期：1983-06-01 00:00:00

  • Ketamine induced cell death can be mediated by voltage dependent calcium channels in PC12 cells.

    abstract：:Ketamine is widely used both as anesthetic and abuse drug. In this study, we investigated the effects of a wide range of ketamine concentrations (100-500-1000 μM) on calcium mobilization and the induction of cell death in undifferentiated PC12 cells, 24 h after treatment. Calcium mobilization was measured as the perce...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104318

    authors： Bustamante J,Acosta L,Karadayian AG,Lores-Arnaiz S

    更新日期：2019-12-01 00:00:00

  • Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard.

    abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.03.002

    authors： Joseph LB,Heck DE,Cervelli JA,Composto GM,Babin MC,Casillas RP,Sinko PJ,Gerecke DR,Laskin DL,Laskin JD

    更新日期：2014-06-01 00:00:00

  • The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis.

    abstract：:Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as t...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.12.001

    authors： Hu JM,Liu K,Liu JH,Jiang XL,Wang XL,Yang L,Chen YZ,Liu CX,Li SG,Cui XB,Zou H,Pang LJ,Zhao J,Qi Y,Liang WH,Yuan XL,Li F

    更新日期：2017-02-01 00:00:00

  • Development of the early mucosal lesions in experimental inflammatory bowel disease--implications for pathogenesis.

    abstract：:The purpose of this study was to better establish the morphologic basis of the early mucosal lesions of experimental inflammatory bowel disease because understanding the development of these lesions has important pathogenetic implications. Sprague-Dawley rats were given 1.5% hydrolyzed lambda-carrageenan orally for 30...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1011

    authors： Moyana TN,Xiang J,Qi Y,Kalra J

    更新日期：1994-04-01 00:00:00

  • Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

    abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice bu...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.04.002

    authors： Brychtova V,Zampachova V,Hrstka R,Fabian P,Novak J,Hermanova M,Vojtesek B

    更新日期：2014-06-01 00:00:00

  • RGC-32 is a novel regulator of the T-lymphocyte cell cycle.

    abstract：:We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we de...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.03.011

    authors： Tegla CA,Cudrici CD,Nguyen V,Danoff J,Kruszewski AM,Boodhoo D,Mekala AP,Vlaicu SI,Chen C,Rus V,Badea TC,Rus H

    更新日期：2015-06-01 00:00:00

  • Cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions: report of 2 cases.

    abstract：:We previously hypothesized that cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions. In this context we evaluated additional cases to further confirm that hypothesis. We report on 2 additional cases in which clonal cytogenetic abnormalities were observed in otherwise morpho...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.10.003

    authors： Symons WA,Flynt FL,Mendiola C,Ortega V,Higgins RA,Velagaleti GV

    更新日期：2013-02-01 00:00:00

  • The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma.

    abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.10.001

    authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

    更新日期：2011-02-01 00:00:00

  • Proliferation of fat-storing cells is stimulated by secretions of Kupffer cells from normal and injured liver.

    abstract：:The influence of Kupffer cells (KC) from normal, D-galactosamine- and thioacetamide-injured liver on the growth of rat liver fat-storing cells (FSC) in culture was studied. The supplementation of FSC incubation medium with normal and galactosamine-KC-conditioned media for 4 days caused 1.5- and 1.9-fold increase (P le...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90023-8

    authors： Zerbe O,Gressner AM

    更新日期：1988-08-01 00:00:00

  • Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor.

    abstract：:Cell death caused by the accumulation of extracellular adenosine is believed to contribute to the profound loss of T lymphocytes in patients with severe combined immunodeficiency disease due to adenosine deaminase deficiency. Although adenosine is known to trigger apoptosis in thymocytes and peripheral T cells, the mo...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.08.001

    authors： El-Darahali A,Fawcett H,Mader JS,Conrad DM,Hoskin DW

    更新日期：2005-12-01 00:00:00

  • Restoration of chemosensitivity in cancer cells with MDR phenotype by deoxyribozyme, compared with ribozyme.

    abstract：:One of the main mechanisms for multidrug resistance (MDR) involves multidrug resistance gene 1 (MDR1) which encodes P-glycoprotein (Pgp). Pgp acts as a drug efflux pump and exports chemotherapeutic agents from cancer cells. Specific inhibition of Pgp expression by gene therapy is considered a well-respective strategy ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.03.004

    authors： Xing AY,Shi DB,Liu W,Chen X,Sun YL,Wang X,Zhang JP,Gao P

    更新日期：2013-06-01 00:00:00

  • Effects of 5-azacytidine in Syrian golden hamsters: toxicity, tumorigenicity, and differential modulation of bronchial carcinogenesis.

    abstract：:5-Azacytidine (AZC) was studied in a lung cancer model in outbred and syngeneic (F1D) hamsters wherein benzol[a]pyrene (BP) from sustained release implants (SRI) induces preneoplastic mucosal changes which progress to bronchogenic cancer. In pilot studies to evaluate AZC toxicity, a dose schedule of 5 mg/kg biweekly w...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(90)90022-6

    authors： Hammond WG,Yellin A,Gabriel A,Paladugu RR,Azumi N,Hill LR,Benfield JR

    更新日期：1990-08-01 00:00:00

  • Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3.

    abstract：:Antigen-specific CD8 suppressor T cells (CD8(+) Ts) are adaptive regulatory T cells that are induced in vivo and in vitro by chronic antigenic stimulation of human T cells. CD8(+) Ts induce the upregulation of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells rendering these antigen presenting ce...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.09.011

    authors： Vlad G,Suciu-Foca N

    更新日期：2012-12-01 00:00:00

  • The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).

    abstract：:As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibro...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.04.002

    authors： Jia Y,Ji P,French B,Tillman B,French SW

    更新日期：2019-06-01 00:00:00

  • Experimental strategies to improve in vitro models of renal ischemia.

    abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2007.03.002

    authors： Russ AL,Haberstroh KM,Rundell AE

    更新日期：2007-10-01 00:00:00

  • Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells.

    abstract：OBJECTIVE:The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. METHODS:Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI ≥ 4) or "inactive" (SLEDAI < 4), 26 RA subject...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.06.003

    authors： Khan SA,Nowatzky J,Jiménez-Branda S,Greenberg JD,Clancy R,Buyon J,Bhardwaj N

    更新日期：2013-10-01 00:00:00

  • A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated.

    abstract：:In the present study, BALB/c mice were used to develop a model for the hepatic injury associated to dengue infection. Histological analysis after subcutaneous inoculation with a low viral dose of dengue-2 virus showed Kupffer cell hyperplasia and an increased inflammatory cellular infiltrate next to the bile ducts on ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.07.007

    authors： França RF,Zucoloto S,da Fonseca BA

    更新日期：2010-12-01 00:00:00

  • RP105 protects against myocardial ischemia-reperfusion injury via suppressing TLR4 signaling pathways in rat model.

    abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.12.016

    authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

    更新日期：2016-04-01 00:00:00

  • Methylation of tumor associated genes in tissue and plasma samples from liver disease patients.

    abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2008.07.001

    authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

    更新日期：2008-10-01 00:00:00

  • X-ray microanalysis of the rat parotid gland after chronic sympathectomimetic stimulation.

    abstract：:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contain...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90024-8

    authors： Müller RM,Roomans GM

    更新日期：1984-12-01 00:00:00

  • Dengue fever and bone marrow myelofibrosis.

    abstract：:Myelofibrosis is characterized by reticulin and/or collagen fibrosis in the bone marrow stroma resulting in secondary cytopenia. In addition to clonal hematologic neoplasms, myelofibrosis may also develop in association with other clinical conditions, including hematological disorders, solid malignancies, Down syndrom...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.07.004

    authors： Qing X,Sun N,Yeh J,Yue C,Cai J

    更新日期：2014-10-01 00:00:00

  • Early atherogenesis in White Carneau pigeons: effect of a short-term regression diet.

    abstract：:The intracellular distribution of lipid shifts from cytoplasmic to lysosomal localization during the progression of atherosclerosis. It has been suggested that this shift may relate to regressability of lesions. The effects of reducing plasma cholesterol on the regression of early cholesterol-induced atherosclerosis w...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(90)90046-g

    authors： Jerome WG,Lewis JC

    更新日期：1990-12-01 00:00:00

  • Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis.

    abstract：:Dendritic cells (DCs) are a subset of antigen-presenting cells (APCs) that are involved in the initiation and control of the immune response to antigens present at the interface with the environment. A limited number of groups have studied DCs in human and animal conjunctiva but no data is available concerning the dif...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.04.007

    authors： Ohbayashi M,Manzouri B,Flynn T,Toda M,Ikeda Y,Nakamura T,Ono SJ

    更新日期：2007-10-01 00:00:00

  • Macrophage degradation of LDL extracted from human aortic plaques: effect of isolation conditions.

    abstract：:Several laboratories have recently reported on the structural and functional characteristics of an LDL fraction isolated from atherosclerotic lesions, designated A-LDL. Given the wide variety of tissue sources and isolation conditions that have been employed, we have addressed whether several procedures currently used...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(91)90045-y

    authors： Hoff HF,O'Neil J,Cole TB

    更新日期：1991-02-01 00:00:00

  • Copper toxicosis and tolerance in the rat. III. Intracellular localization of copper in the liver and kidney.

    abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90041-3

    authors： Haywood S,Loughran M,Batt RM

    更新日期：1985-10-01 00:00:00

  • Hemodynamic and electrophysiological effects of mercury in intact anesthetized rabbits and in isolated perfused hearts.

    abstract：:Using intact anesthetized rabbits and isolated perfused hearts, the hemodynamic and electrophysiological effects of mercury (Hg) were examined in order to assess the role of cardiovascular dysfunction in Hg intoxication. The most consistent and prominent cardiovascular effect was a significant reduction in blood press...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(89)90038-5

    authors： Rhee HM,Choi BH

    更新日期：1989-06-01 00:00:00

  • Naturally occurring modified low density lipoproteins are similar if not identical: more electronegative and desialylated lipoprotein subfractions.

    abstract：:Previous studies demonstrated that more electronegative low density lipoprotein (LDL) isolated from human blood by ion exchange chromatography has a chemical composition and physical properties similar to desialylated LDL obtained by lectin chromatography (Avogaro et al., 1988; Orekhov et al., 1989). In this study, si...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1995.1018

    authors： Tertov VV,Bittolo-Bon G,Sobenin IA,Cazzolato G,Orekhov AN,Avogaro P

    更新日期：1995-06-01 00:00:00

  • Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain.

    abstract：:The N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, is considered to have a close relationship to synaptic plasticity in the developing brain. In addition, it is known that the excessive stimulation of NMDARs can trigger neuronal apoptosis. In this study, we examined the distribution of...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00030-3

    authors： Takai H,Katayama K,Uetsuka K,Nakayama H,Doi K

    更新日期：2003-08-01 00:00:00

  • Increased protein carbonylation of red blood cell membrane in diabetic retinopathy.

    abstract：:We investigated the protein carbonylation of red blood cell (RBC) membrane in type 2 diabetic patients and the potential implication of carbonyl/oxidative stress in reflecting disease severity. Sixty-four diabetic patients with or without retinopathy of variable clinical severity (Groups DR and DM, respectively) and 2...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.04.001

    authors： Margetis PI,Antonelou MH,Petropoulos IK,Margaritis LH,Papassideri IS

    更新日期：2009-08-01 00:00:00