Abstract:
:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contained more and larger zymogen granules than acinar cells in the controls. The zymogen granules contained markedly less sulfur, potassium, and calcium than in control animals. Prenalterol had effects similar to those of isoproterenol, but less pronounced, whereas terbutaline had no significant effects. Chronic treatment with reserpine caused a decrease in calcium levels but did not affect potassium levels. The changes in elemental composition in parotid acinar cells after chronic treatment with isoproterenol and reserpine differed from those induced by the same treatment in the submandibular gland of the rat.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Müller RM,Roomans GMdoi
10.1016/0014-4800(84)90024-8subject
Has Abstractpub_date
1984-12-01 00:00:00pages
363-70issue
3eissn
0014-4800issn
1096-0945pii
0014-4800(84)90024-8journal_volume
41pub_type
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