X-ray microanalysis of the rat parotid gland after chronic sympathectomimetic stimulation.

Abstract:

:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contained more and larger zymogen granules than acinar cells in the controls. The zymogen granules contained markedly less sulfur, potassium, and calcium than in control animals. Prenalterol had effects similar to those of isoproterenol, but less pronounced, whereas terbutaline had no significant effects. Chronic treatment with reserpine caused a decrease in calcium levels but did not affect potassium levels. The changes in elemental composition in parotid acinar cells after chronic treatment with isoproterenol and reserpine differed from those induced by the same treatment in the submandibular gland of the rat.

journal_name

Exp Mol Pathol

authors

Müller RM,Roomans GM

doi

10.1016/0014-4800(84)90024-8

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

363-70

issue

3

eissn

0014-4800

issn

1096-0945

pii

0014-4800(84)90024-8

journal_volume

41

pub_type

杂志文章
  • Effect of exogenous thyroxine on the development of the Purkinje cell in fetal alcohol effects in the rat.

    abstract::The amelioration of fetal alcohol effects on the postnatal development of the Purkinje cell by exogenous L-thyroxine was investigated in the neonatal rat. Time-pregnant rats were divided into three groups. Group A (n = 6) received 35% liquid ethanol diet; Group B (n = 6) was fed a liquid diet in which maltose dextrins...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1006/exmp.1999.2283

    authors: Nathaniel EJ,Hassard T,Burton L,Novak C

    更新日期:1999-12-01 00:00:00

  • Dsp rul: a spontaneous mouse mutation in desmoplakin as a model of Carvajal-Huerta syndrome.

    abstract::Studies of spontaneous mutations in mice have provided valuable disease models and important insights into the mechanisms of human disease. Ruffled (rul) is a new autosomal recessive mutation causing abnormal hair coat in mice. The rul allele arose spontaneously in the RB156Bnr/EiJ inbred mouse strain. In addition to ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2015.01.015

    authors: Herbert Pratt C,Potter CS,Fairfield H,Reinholdt LG,Bergstrom DE,Harris BS,Greenstein I,Dadras SS,Liang BT,Schofield PN,Sundberg JP

    更新日期:2015-04-01 00:00:00

  • An ultrastructural study of the acute effects of 4-nitroquinoline 1-oxide on the hamster lung.

    abstract::The alterations, visible by light and electron microscopy, in the distal airway cells of Syrian golden hamsters were analyzed at several time intervals, from 6 hr to 4 weeks, after a single subcutaneous injection (120 mg/kg body wt) of 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen. 4NQO induced injurious effect...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(85)90029-2

    authors: Ito T

    更新日期:1985-04-01 00:00:00

  • An Oct-1-based, feed-forward mechanism of apoptosis inhibited by co-culture with Raji B-cells: towards a model of the cancer cell/B-cell microenvironment.

    abstract::A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2014.09.010

    authors: Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

    更新日期:2014-12-01 00:00:00

  • Ketamine inhibits colorectal cancer cells malignant potential via blockage of NMDA receptor.

    abstract::Ketamine, a common N-methyl-d-aspartate receptor (NMDAR) antagonist, is an option for cancer pain treatment in clinical practice. Ketamine has been shown to have the capacity to attenuate cancer cells malignancy. However, the underlying mechanism remains elusive. In the present study, we reported that ketamine inhibit...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2019.02.004

    authors: Duan W,Hu J,Liu Y

    更新日期:2019-04-01 00:00:00

  • Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.

    abstract::Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2020.104408

    authors: Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

    更新日期:2020-06-01 00:00:00

  • Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.

    abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice bu...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2014.04.002

    authors: Brychtova V,Zampachova V,Hrstka R,Fabian P,Novak J,Hermanova M,Vojtesek B

    更新日期:2014-06-01 00:00:00

  • An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia.

    abstract::The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(85)90030-9

    authors: Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

    更新日期:1985-04-01 00:00:00

  • Effect of lead on the biological activity of calmodulin in rat brain.

    abstract::In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The ad...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1006/exmp.1994.1026

    authors: Sandhir R,Gill KD

    更新日期:1994-08-01 00:00:00

  • Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance.

    abstract:OBJECTIVE:Annexins are a family of intracellular proteins that bind membrane phospholipids in a Ca(2+) concentration-dependent manner. Several annexins play important roles during tumor progression. However, little is known about the clinical implications and biological functions of Annexin A3 in breast cancer. METHOD...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2013.04.002

    authors: Zeng C,Ke Z,Song Y,Yao Y,Hu X,Zhang M,Li H,Yin J

    更新日期:2013-08-01 00:00:00

  • Genome-wide analysis of loss of heterozygosity and copy number amplification in uterine leiomyomas using the 100K single nucleotide polymorphism array.

    abstract:PURPOSE:Uterine leiomyomas (fibroids) are benign smooth muscle tumors commonly found among reproductive-aged women. Though benign, these tumors are the leading indication for hysterectomies in the United States and cause significant morbidity. Despite the importance of this tumor in women's health, relatively little is...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2011.03.007

    authors: Meadows KL,Andrews DM,Xu Z,Carswell GK,Laughlin SK,Baird DD,Taylor JA

    更新日期:2011-08-01 00:00:00

  • Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms.

    abstract::Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2013.06.007

    authors: Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

    更新日期:2013-08-01 00:00:00

  • Prevalence of MTHFR gene polymorphisms (C677T and A1298C) among Tamilians.

    abstract::We have investigated the incidence of the C677T and A1298C methylene tetrahydrofolate reductase (MTHFR) gene single nucleotide polymorphisms (SNPs) in the South Indian Tamil Nadu population with a total number of 72 individuals. The MTHFR genotyping was performed using the polymerase chain reaction followed by restric...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2004.04.006

    authors: Angeline T,Jeyaraj N,Granito S,Tsongalis GJ

    更新日期:2004-10-01 00:00:00

  • Successful treatment of autoimmune manifestations in MRL/l and MRL/n mice using total lymphoid irradiation (TLI).

    abstract::The autoimmune manifestations of MRL-+/+ (MRL/n) and MRL/Mp-lpr/lpr (MRL/l) murine models of systemic lupus erythematosus (SLE) were successfully reversed following total lymphoid irradiation (TLI) therapy consisting of 8-12 daily fractions of 200 rad. Following radiotherapy the characteristic lymphadenopathy of MRL/l...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(83)90096-5

    authors: Moscovitch M,Rosenmann E,Neeman Z,Slavin S

    更新日期:1983-02-01 00:00:00

  • Accelerated thymocyte maturation in IL-12Rβ2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination.

    abstract::IL-12Rβ2(-/-) mice, which are unresponsive to IL-12, develop severe experimental autoimmune encephalomyelitis (EAE). The mechanisms for enhanced autoimmunity are incompletely understood. We report that in IL-12Rβ2(-/-) mice, thymocytes undergo markedly accelerated maturation. This occurs at the transition from a doubl...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2010.06.003

    authors: Gran B,Yu S,Zhang GX,Rostami A

    更新日期:2010-10-01 00:00:00

  • Clinical significance of 21-gene recurrence score assay for hormone receptor-positive, lymph node-negative breast cancer in early stage.

    abstract:OBJECTIVE:To identify the relationship between clinical pathological characteristics and the recurrence score (RS) on a 21-gene expression assay in patients with hormone receptor-positive, node-negative breast cancer, as well as the effect of RS on adjuvant decision-making. METHODS:The retrospective study was conducte...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2019.04.013

    authors: Yu-Qing Y,Lei W,Mei-Ling H,Jing-Jing X,Mei-Chen W,Jiang W,Jun-Sheng H,Rui L,Nan-Lin L

    更新日期:2019-06-01 00:00:00

  • Histone gene (H3) expression in chemically transformed oral keratinocytes.

    abstract::The hamster cheek pouch is an excellent target tissue for the experimental study of oral carcinogenesis. In the course of searching for molecular alterations during the malignant transformation process, the necessity for a molecular marker for cellular proliferation became apparent. In this report, we show that the ce...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(88)90034-2

    authors: Wong DT

    更新日期:1988-10-01 00:00:00

  • c-Yes enhances tumor migration and invasion via PI3K/AKT pathway in epithelial ovarian cancer.

    abstract::Overexpression of c-Yes has been noted to correlation with several human cancers. However, the effects of c-Yes on epithelial ovarian cancer (EOC) development remain unclear. The aim of this study is going to prove the effects of c-Yes and related mechanisms in proliferation, metastasis and invasion of EOC. Immunohist...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2016.06.002

    authors: Jin Y,Huang M,Wang Y,Yi C,Deng Y,Chen Y,Jiang L,Wang J,Shen Q,Liu R,QinghuaXi

    更新日期:2016-08-01 00:00:00

  • Obliterative airway disease in rat tracheal allografts requires tumor necrosis factor alpha.

    abstract::Obliterative bronchiolitis is the major complication affecting long-term lung transplant survivors. Tumor necrosis factor-alpha (TNF-alpha) promotes inflammation and fibrosis in chronic lung injury models. These experiments defined the role of TNF-alpha in an established model of obliterative airway disease (OAD). Rat...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2004.10.008

    authors: Farivar AS,Mackinnon-Patterson B,McCourtie AS,Namkung J,Ward PA,Mulligan MS

    更新日期:2005-06-01 00:00:00

  • Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker.

    abstract::We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes and foam cells. Seventy Wistar rats were assigned to one of the following groups: (1) regular diet, (2) an atherogenic di...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(92)90010-9

    authors: Nunnari JJ,Fisher M,White SD

    更新日期:1992-12-01 00:00:00

  • Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease.

    abstract::The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2005.03.007

    authors: Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

    更新日期:2005-10-01 00:00:00

  • Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor.

    abstract::Cell death caused by the accumulation of extracellular adenosine is believed to contribute to the profound loss of T lymphocytes in patients with severe combined immunodeficiency disease due to adenosine deaminase deficiency. Although adenosine is known to trigger apoptosis in thymocytes and peripheral T cells, the mo...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2005.08.001

    authors: El-Darahali A,Fawcett H,Mader JS,Conrad DM,Hoskin DW

    更新日期:2005-12-01 00:00:00

  • Cytokine levels in HIV infected and uninfected Indian women: correlation with other STAs.

    abstract::Host immune status is an important determinant of disease progression. Infections in the genital tract may alter the immunity in the particular site and hence affect the production of local cytokines. We performed this study to determine whether HIV in association with cervical HPV and CT/GC infections influences the ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2008.10.001

    authors: Guha D,Chatterjee R

    更新日期:2009-02-01 00:00:00

  • Angiographic evaluation of the rat carotid balloon injury model.

    abstract:RATIONALE:The rat carotid balloon-injury (BI) model is a widely used model of intimal hyperplasia (IH) and vascular remodeling. A variable degree of IH after BI has been previously reported, and we have encountered technical challenges and suboptimal results with the original method. OBJECTIVE:To evaluate the original...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2011.06.011

    authors: Orozco LD,Liu H,Chen BB,Fratkin JD,Perkins E

    更新日期:2011-10-01 00:00:00

  • Increased density of macrophage migration inhibitory factor (MIF) in tuberculosis granuloma.

    abstract::Granulomas, the pathologic hallmarks of tuberculosis, are composed of tightly numerous immune cells that respond to a variety of persistent stimuli during pathogen-host interaction. The granuloma is essential for host containment of mycobacterial infection, however, the mechanism of host and pathogen determinants to r...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2012.05.004

    authors: Wang D,Zhou W,Lu S,Wang Q,Feng Y,Zhu G,Li L,Song Y,Gao Q

    更新日期:2012-10-01 00:00:00

  • Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine.

    abstract::Minoxidil, a vasodilating antihypertensive drug, was given orally at 10 mg/kg daily for 2 days to twelve 25- to 35-kg miniature pigs. Twelve control pigs were also studied. Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose. Gross examination showed diffuse hemorrhage in...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(84)90003-0

    authors: Van Vleet JF,Herman EH,Ferrans VJ

    更新日期:1984-08-01 00:00:00

  • Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis.

    abstract::Dendritic cells (DCs) are a subset of antigen-presenting cells (APCs) that are involved in the initiation and control of the immune response to antigens present at the interface with the environment. A limited number of groups have studied DCs in human and animal conjunctiva but no data is available concerning the dif...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2007.04.007

    authors: Ohbayashi M,Manzouri B,Flynn T,Toda M,Ikeda Y,Nakamura T,Ono SJ

    更新日期:2007-10-01 00:00:00

  • Restoration of chemosensitivity in cancer cells with MDR phenotype by deoxyribozyme, compared with ribozyme.

    abstract::One of the main mechanisms for multidrug resistance (MDR) involves multidrug resistance gene 1 (MDR1) which encodes P-glycoprotein (Pgp). Pgp acts as a drug efflux pump and exports chemotherapeutic agents from cancer cells. Specific inhibition of Pgp expression by gene therapy is considered a well-respective strategy ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/j.yexmp.2013.03.004

    authors: Xing AY,Shi DB,Liu W,Chen X,Sun YL,Wang X,Zhang JP,Gao P

    更新日期:2013-06-01 00:00:00

  • The morphological development of glycol ether-induced testicular atrophy in the rat.

    abstract::The testicular effects of daily oral dosing with two glycol ethers--either ethylene glycol monomethyl ether (EGM) or monoethyl ether (EGE) were studied in the prepubertal rat by histological examination of the testes. Over the 11-day dosing period studied, EGM was found to produce testicular damage at dose levels of a...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/0014-4800(84)90074-1

    authors: Creasy DM,Foster PM

    更新日期:1984-04-01 00:00:00

  • Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice.

    abstract::Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章

    doi:10.1016/s0014-4800(99)80003-3

    authors: Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

    更新日期:1999-02-01 00:00:00