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c-Yes enhances tumor migration and invasion via PI3K/AKT pathway in epithelial ovarian cancer.

Abstract：

:Overexpression of c-Yes has been noted to correlation with several human cancers. However, the effects of c-Yes on epithelial ovarian cancer (EOC) development remain unclear. The aim of this study is going to prove the effects of c-Yes and related mechanisms in proliferation, metastasis and invasion of EOC. Immunohistochemical analysis was performed in 119 human EOC samples, and the data was correlated with clinic pathologic features. Furthermore, western blot analysis is performed for c-Yes in EOC samples and cell lines to evaluate their protein levels and molecular interaction. Kaplan-Meier survival analysis shows that the strong expression of c-Yes exhibited a significant correlation with poor prognosis in human EOC (P<0.01(⁎)). Meanwhile, we found that knockdown of c-Yes by shRNA inhibited the ability of migration and invasion in EOC cells via the PI3K/AKT pathway. In a word, these results suggested that c-Yes plays an important role in migration and invasion of EOC.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Jin Y,Huang M,Wang Y,Yi C,Deng Y,Chen Y,Jiang L,Wang J,Shen Q,Liu R,QinghuaXi

doi

10.1016/j.yexmp.2016.06.002

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

50-7

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(16)30109-5

journal_volume

101

pub_type

杂志文章

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