Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.

abstract：:In this comparative study, rat hearts were perfused at 37 degrees C with three clearly defined protocols: the Ca2+ paradox, the O(2) paradox, and with 20 mM caffeine. Each protocol involved an initial priming (Ca(2+)(0) depletion or anoxia; stage 1) and subsequent full activation (Ca(2+)(0) repletion, caffeine or reox...

journal_title：Experimental and molecular pathology

authors： Harding RJ,Duncan CJ

更新日期：1999-10-01 00:00:00

abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

journal_title：Experimental and molecular pathology

authors： Li J,French BA,Fu P,French SW

更新日期：2001-08-01 00:00:00

abstract：:The influence of Kupffer cells (KC) from normal, D-galactosamine- and thioacetamide-injured liver on the growth of rat liver fat-storing cells (FSC) in culture was studied. The supplementation of FSC incubation medium with normal and galactosamine-KC-conditioned media for 4 days caused 1.5- and 1.9-fold increase (P le...

journal_title：Experimental and molecular pathology

authors： Zerbe O,Gressner AM

更新日期：1988-08-01 00:00:00

abstract：:The thrombocyte is the avian equivalent of the mammalian blood platelet and is involved in hemostasis through a fibrinogen-mediated process. Although fibrinogen has been implicated as a molecular bridge between activated cells during aggregation, the location of this molecule and its receptor on thrombocytes has not b...

journal_title：Experimental and molecular pathology

authors： O'Toole ET,Hantgan RR,Lewis JC

更新日期：1994-12-01 00:00:00

abstract：:Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor in major and minor salivary glands (SGs). We have recently identified human cytomegalovirus (hCMV) as a principle component in the multifactorial causation of SG-MEC. This finding is corroborated by the ability of the purified mouse CMV (mCMV) to ind...

journal_title：Experimental and molecular pathology

authors： Melnick M,Deluca KA,Jaskoll T

更新日期：2014-08-01 00:00:00

abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

journal_title：Experimental and molecular pathology

authors： Saba TM,Cho E,Blumenstock FA

更新日期：1984-08-01 00:00:00

abstract：:Mast cells play a key role in immunoglobulin E (IgE)-associated allergic disorders; however, the cellular effects of sensitization remain poorly understood. Using gene microarrays and the multiplexing ELISA method, we examined the effects of sensitization on RBL-CCR1 cell transcription and chemokine/cytokine secretion...

journal_title：Experimental and molecular pathology

authors： Kuo CH,Morohoshi K,Aye CC,Garoon RB,Collins A,Ono SJ

更新日期：2012-12-01 00:00:00

abstract：:IL-12Rβ2(-/-) mice, which are unresponsive to IL-12, develop severe experimental autoimmune encephalomyelitis (EAE). The mechanisms for enhanced autoimmunity are incompletely understood. We report that in IL-12Rβ2(-/-) mice, thymocytes undergo markedly accelerated maturation. This occurs at the transition from a doubl...

journal_title：Experimental and molecular pathology

authors： Gran B,Yu S,Zhang GX,Rostami A

更新日期：2010-10-01 00:00:00

abstract：:The aim of this study is to determine if warm ischemia after surgical extirpation impacts gene expression in tissue samples which will be used for cDNA array analysis. We investigated effects of warm ischemia on gene expression in lung, liver, kidney, and spleen of rats, chronologically, using an original cDNA array, ...

journal_title：Experimental and molecular pathology

authors： Miyatake Y,Ikeda H,Michimata R,Koizumi S,Ishizu A,Nishimura N,Yoshiki T

更新日期：2004-12-01 00:00:00

abstract：:Apolipoprotein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a key role in the progression of glomerulosclerosis (GS). We conducted this investigation to explore whether all-trans retinoic acid (ATRA) could regulate the apoE expression in the pathological process of GS. 120 Wistar rats w...

journal_title：Experimental and molecular pathology

authors： Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

更新日期：2011-06-01 00:00:00

abstract：:Minoxidil, a vasodilating antihypertensive drug, was given orally at 10 mg/kg daily for 2 days to twelve 25- to 35-kg miniature pigs. Twelve control pigs were also studied. Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose. Gross examination showed diffuse hemorrhage in...

journal_title：Experimental and molecular pathology

authors： Van Vleet JF,Herman EH,Ferrans VJ

更新日期：1984-08-01 00:00:00

abstract：:The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

journal_title：Experimental and molecular pathology

authors： Donoff RB,Swann DA,Schweidt SH

更新日期：1984-02-01 00:00:00

abstract：:We have previously described the generation of a monoclonal antibody recognizing a novel cholangiocyte marker, designated BD.1, that is expressed by fetal and adult rat cholangiocytes but not hepatocytes or the hepatic progenitor cells known as oval cells. In the present report, we have undertaken a comprehensive exam...

journal_title：Experimental and molecular pathology

authors： Mills DR,Rozich RA,Flanagan DL,Brilliant KE,Yang D,Hixson DC

更新日期：2012-10-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family. We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells. CP-like lesions are characterized by acinar and ductal-ductular cell p...

journal_title：Experimental and molecular pathology

authors： Naito Z,Ishiwata T,Lu YP,Teduka K,Fujii T,Kawahara K,Sugisaki Y

更新日期：2003-02-01 00:00:00

abstract：:Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-neg...

journal_title：Experimental and molecular pathology

authors： Qing X,Sun N,Chang E,French S,Ji P,Yue C

更新日期：2011-02-01 00:00:00

abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

journal_title：Experimental and molecular pathology

authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

更新日期：2008-10-01 00:00:00

abstract：:Myocardial collagen and total protein synthesis were studied in normal, diabetic, and insulin-treated diabetic rats after a single intraperitoneal injection of L-[2,3-3H]proline as a radioisotopic precursor. The incorporation of tritiated proline into myocardial protein was regarded as a measure of total protein synth...

journal_title：Experimental and molecular pathology

authors： Reddi AS

更新日期：1988-04-01 00:00:00

abstract：:Ketamine is widely used both as anesthetic and abuse drug. In this study, we investigated the effects of a wide range of ketamine concentrations (100-500-1000 μM) on calcium mobilization and the induction of cell death in undifferentiated PC12 cells, 24 h after treatment. Calcium mobilization was measured as the perce...

journal_title：Experimental and molecular pathology

authors： Bustamante J,Acosta L,Karadayian AG,Lores-Arnaiz S

更新日期：2019-12-01 00:00:00

abstract：:A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminate...

journal_title：Experimental and molecular pathology

authors： Ye H,Wang Y,Yan J,Jenson AB

更新日期：2016-12-01 00:00:00

abstract：:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholam...

journal_title：Experimental and molecular pathology

authors： Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

更新日期：1984-12-01 00:00:00

abstract：:Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

journal_title：Experimental and molecular pathology

authors： Winocour PD,Hryhorenko L

更新日期：1995-12-01 00:00:00

abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

journal_title：Experimental and molecular pathology

authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

更新日期：2007-12-01 00:00:00

abstract：:As a first step in studies on the molecular mechanism(s) underlying gentamicin toxicity, the effect of treating rats with this aminoglycoside antibiotic (100 mg/kg once or twice daily for 3 days) on the analytical subfractionation of the kidney cortex has been examined. DNA was used as a marker for the nuclei, cytochr...

journal_title：Experimental and molecular pathology

authors： Nässberger L,Bergstrand A,DePierre JW

更新日期：1987-04-01 00:00:00

abstract：:FineFix, RCL-2 and HOPE, three formalin-free fixatives, were compared to the common used formalin fixed tissue samples of lung cancer and were evaluated for their effects on quality, quantity and integrity of RNA and microRNA. Two commercially available RNA extraction Kits (RNeasy FFPE by Qiagen and RecoverAll™ Nuclei...

journal_title：Experimental and molecular pathology

authors： Arzt L,Kothmaier H,Quehenberger F,Halbwedl I,Wagner K,Maierhofer T,Popper HH

更新日期：2011-10-01 00:00:00

abstract：:Carbon tetrachloride-mediated loss of cytochrome P-450 has been compared in hepatic microsomes from untreated and phenobarbital-treated rats. At concentrations of carbon tetrachloride greater than 2.5 mM, a direct effect (i.e., NADPH- independent) on cytochrome P-450 was observed. This apparently arose from the "solve...

journal_title：Experimental and molecular pathology

authors： Moody DE,Head B,Woo CH,James JL,Smuckler EA

更新日期：1986-06-01 00:00:00

abstract：:Macrophages play an essential role in pulmonary host defense. They are, however, a heterogeneous cell population located in different lung compartments. This study was designed to elucidate differences between two macrophage populations obtained from the human lung, i.e., alveolar macrophages (AM) and interstitial mac...

journal_title：Experimental and molecular pathology

authors： Fathi M,Johansson A,Lundborg M,Orre L,Sköld CM,Camner P

更新日期：2001-04-01 00:00:00

abstract：:Interactions of the basic multivalent ligand cationized ferritin (CF) with cultured cells markedly alter their endocytic function. In this study, the influence of CF treatment on the binding, internalization, and degradation of chemically modified (acetylated) low-density lipoproteins (Ac-LDL) was examined in aortic s...

journal_title：Experimental and molecular pathology

authors： Sprague EA,Edwards EH,Valente AJ,Suenram CA,Kerbacher JJ,Schwartz CJ

更新日期：1988-06-01 00:00:00

abstract：:Male Wistar rats were administered daily intraperitoneal injections of 125, 250, 500, and 1000 mg/kg/day of vitamin B6 for 2 and 6 weeks and the histogenesis of the testicular damage was investigated. A reduction of germ cells was not prominent in the 2-week groups, whereas a delay in spermiation, degeneration of elon...

journal_title：Experimental and molecular pathology

authors： Kaido M,Mori K,Ide Y,Inoue N,Koide O

更新日期：1991-08-01 00:00:00

abstract：:Angiocidin, a tumor-associated peptide, has been previously shown to inhibit tumor progression by blocking angiogenesis. We now show that angiocidin has a direct inhibitory effect on tumor cell proliferation. MDA-MB-231 breast cancer cells were inhibited from proliferating in the presence of epidermal growth factor (E...

journal_title：Experimental and molecular pathology

authors： Godek J,Sargiannidou I,Patel S,Hurd L,Rothman VL,Tuszynski GP

更新日期：2011-06-01 00:00:00

abstract：:DNA isolated from the culture of an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus has been cloned. A region of the virus that contains genes coding proteins homologous to the UL141, UL144, and UL145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several dis...

journal_title：Experimental and molecular pathology

authors： Martin WJ

更新日期：1999-04-01 00:00:00