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Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver.

Abstract：

:Chemerin is a recently described adipokine whose adipose tissue and serum levels are increased in obesity. Chemerin is expressed in the liver, and here, expression of chemerin has been studied in liver cells and in non-alcoholic fatty liver disease (NAFLD) which is more often found in obesity. Chemerin is shown to be highly expressed in primary human hepatocytes (PHH) whereas hepatic stellate cells (HSC) produce only low levels of this protein. In mice fed a high fat diet hepatic chemerin mRNA but not protein is increased. Chemerin protein is comparably expressed in the liver of control animals and ob/ob mice. Rodents fed a Paigen diet or methionine-choline deficient diet (MCD) develop non-alcoholic steatohepatitis (NASH), and liver chemerin protein tends to be higher in the first and is significantly increased in the latter. Of note, MCD fed mice have similar serum chemerin levels as the respective control animals despite lower body weight. In human fatty liver and NASH liver chemerin mRNA also tends to be induced. Cytokines like TNF and adipokines with an established role in NASH do not considerably affect PHH chemerin protein. The antidiabetic drug metformin reduces cellular and soluble chemerin in PHH as has already been described in adipose tissue. In conclusion current data show that primary human hepatocytes are a major source of hepatic chemerin and increased liver chemerin in NASH may even contribute to systemic levels.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Krautbauer S,Wanninger J,Eisinger K,Hader Y,Beck M,Kopp A,Schmid A,Weiss TS,Dorn C,Buechler C

doi

10.1016/j.yexmp.2013.07.009

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

199-205

issue

2

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(13)00095-6

journal_volume

95

pub_type

杂志文章

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