当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Genome-wide analysis of loss of heterozygosity and copy number amplification in uterine leiomyomas using the 100K single nucleotide polymorphism array.

Genome-wide analysis of loss of heterozygosity and copy number amplification in uterine leiomyomas using the 100K single nucleotide polymorphism array.

Abstract：

PURPOSE:Uterine leiomyomas (fibroids) are benign smooth muscle tumors commonly found among reproductive-aged women. Though benign, these tumors are the leading indication for hysterectomies in the United States and cause significant morbidity. Despite the importance of this tumor in women's health, relatively little is known about the molecular etiology. METHODS:In this study, we used the Affymetrix 100K single nucleotide polymorphism (SNP) chip to assess whether the pattern and frequency of genome-wide loss of heterozygosity (LOH) and copy number amplifications is associated with clinical heterogeneity. RESULTS:Thirty-seven tumors with varying sizes and histology from eleven patients were analyzed. LOH was observed in 4/37 tumors (10.8%) and significantly associated with large-sized tumors (p<0.0014). Two tumors revealed hemizygosity on chromosome 7q, a region that has been consistently reported to have LOH. Additionally, we detected one novel region of LOH, 16p13.11 in one tumor (2.7%). Copy number amplifications were observed on all chromosomes; however, most were low-level amplifications and only detected in a single tumor. One region of amplification at 3p26.3 was detected in four tumors. CONCLUSIONS:Despite the use of a high-density SNP platform, our results suggest that genome-wide LOH and copy number amplifications are infrequent events and generally do not determine clinical and histologic characteristics of this disease.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Meadows KL,Andrews DM,Xu Z,Carswell GK,Laughlin SK,Baird DD,Taylor JA

doi

10.1016/j.yexmp.2011.03.007

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

434-9

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(11)00030-X

journal_volume

91

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma.

    abstract：PURPOSE:Tumor supressor gene FHIT was identified at chromosome 3p14.2 spanning the FRA3B fragile site and is very often inactivated in different types of cancer. The aim of this study was to examine the frequency of FHIT gene LOH as well as FHIT mRNA and protein expression in sporadic colon adenocarcinoma. METHODS:The...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.12.005

    authors： Kapitanović S,Čačev T,Lončar B,Catela Ivković T,Križanac Š,Pavelić K

    更新日期：2014-02-01 00:00:00

  • RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity.

    abstract：:Retinoids influence the pathogenesis of alcohol liver disease (ALD). To analyze the impact of retinoid X receptor alpha (RXRalpha) on ALD, alcohol-induced hepatotoxicity was studied using mice fed ethanol intragastrically for 25 days. Alcohol-induced microvesicular fat around the central vein and drug-induced morpholo...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00091-1

    authors： Dai T,Wu Y,Leng AS,Ao Y,Robel RC,Lu SC,French SW,Wan YJ

    更新日期：2003-12-01 00:00:00

  • Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer.

    abstract：:Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor im...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.04.010

    authors： Sakiyama MJ,Espinoza I,Reddy A,de Carlo F,Kumar A,Levenson AS,Bae S,Zhou X,Claudio PP,Lewin J,Manucha V,Pound CR,Vijayakumar S,Gomez CR

    更新日期：2019-06-01 00:00:00

  • Spontaneous diabetes in BB Wistar rats causes small increases in the early proliferative response of smooth muscle cells in re-injured aortae.

    abstract：:Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1995.1040

    authors： Winocour PD,Hryhorenko L

    更新日期：1995-12-01 00:00:00

  • Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients.

    abstract：:MHC class I polypeptide-related chain A (MICA), mapping to 6p21.33, belongs to the non-classical class I family and its expression is induced by several stress factors including viral infection. A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be signif...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.yexmp.2013.08.005

    authors： Al-Qahtani AA,Al-Anazi M,Abdo AA,Sanai FM,Al-Hamoudi W,Alswat KA,Al-Ashgar HI,Khalaf N,Viswan N,Al-Ahdal MN

    更新日期：2013-12-01 00:00:00

  • The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).

    abstract：:As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibro...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.04.002

    authors： Jia Y,Ji P,French B,Tillman B,French SW

    更新日期：2019-06-01 00:00:00

  • Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile.

    abstract：:Paraoxonase gene polymorphisms (PON1-55 and PON1-192) were determined in four Mexican populations (Mestizos, Nahuas, Teenek and Mayos) belonging to different ethnic groups. The role of these polymorphisms in the lipid profile in the Mestizo group was also analyzed. PON1 polymorphisms were determined by polymerase chai...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.05.006

    authors： Gamboa R,Zamora J,Rodríguez-Pérez JM,Fragoso JM,Cardoso G,Posadas-Romero C,Vargas-Alarcón G

    更新日期：2006-02-01 00:00:00

  • NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.

    abstract：:Carbon tetrachloride-mediated loss of cytochrome P-450 has been compared in hepatic microsomes from untreated and phenobarbital-treated rats. At concentrations of carbon tetrachloride greater than 2.5 mM, a direct effect (i.e., NADPH- independent) on cytochrome P-450 was observed. This apparently arose from the "solve...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(86)90045-6

    authors： Moody DE,Head B,Woo CH,James JL,Smuckler EA

    更新日期：1986-06-01 00:00:00

  • Differential expression of pentraxin 3 in neutrophils.

    abstract：:Pentraxins belong to the superfamily of conserved proteins that are characterized by a cyclic multimeric structure. Pentraxin 3 (PTX3) is a long pentraxin which can be produced by different cell types upon exposure to various inflammatory signals. Inside the neutrophil PTX3 is stored in form of granules localized in t...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.11.009

    authors： Razvina O,Jiang S,Matsubara K,Ohashi R,Hasegawa G,Aoyama T,Daigo K,Kodama T,Hamakubo T,Naito M

    更新日期：2015-02-01 00:00:00

  • Antibodies to squalene in recipients of anthrax vaccine.

    abstract：:We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in...

    journal_title：Experimental and molecular pathology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1006/exmp.2002.2429

    authors： Asa PB,Wilson RB,Garry RF

    更新日期：2002-08-01 00:00:00

  • Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis.

    abstract：:Dendritic cells (DCs) are a subset of antigen-presenting cells (APCs) that are involved in the initiation and control of the immune response to antigens present at the interface with the environment. A limited number of groups have studied DCs in human and animal conjunctiva but no data is available concerning the dif...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.04.007

    authors： Ohbayashi M,Manzouri B,Flynn T,Toda M,Ikeda Y,Nakamura T,Ono SJ

    更新日期：2007-10-01 00:00:00

  • An ultrastructural study of the acute effects of 4-nitroquinoline 1-oxide on the hamster lung.

    abstract：:The alterations, visible by light and electron microscopy, in the distal airway cells of Syrian golden hamsters were analyzed at several time intervals, from 6 hr to 4 weeks, after a single subcutaneous injection (120 mg/kg body wt) of 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen. 4NQO induced injurious effect...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90029-2

    authors： Ito T

    更新日期：1985-04-01 00:00:00

  • TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected].

    abstract：:Several studies recognize cancer-stromal fibroblasts' role in cancer-cell invasion and metastasis. Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.09.001

    authors： Chen H,Yang WW,Wen QT,Xu L,Chen M

    更新日期：2009-12-01 00:00:00

  • Liver necrosis induced by thyroid hormone administration in rats fed ethanol.

    abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2381

    authors： Li J,French BA,Fu P,French SW

    更新日期：2001-08-01 00:00:00

  • The pancreas in the degu.

    abstract：:Unique alpha-cell crystals, a herpes-like virus, islet amyloidosis, and immunohistochemical reactions of islets are compared in the rodent, Octodon degus, in animals with ordinary and high circulating glucose levels. Results suggest that crystals, virus, and amyloid are independent of blood sugar and bear no obvious r...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90047-9

    authors： Spear GS,Caple MV,Sutherland LR

    更新日期：1984-06-01 00:00:00

  • Collagen metabolism in the myocardium of normal and diabetic rats.

    abstract：:Myocardial collagen and total protein synthesis were studied in normal, diabetic, and insulin-treated diabetic rats after a single intraperitoneal injection of L-[2,3-3H]proline as a radioisotopic precursor. The incorporation of tritiated proline into myocardial protein was regarded as a measure of total protein synth...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90060-3

    authors： Reddi AS

    更新日期：1988-04-01 00:00:00

  • Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase. VII. Evidence for selective advantage of one phenotype over the other in ditypic samples from aortas of hares fed cholesterol oxidation products.

    abstract：:In a previous study the authors demonstrated monotypic foci, all of timidus type, in the atherosclerotic lesions and normal aortic tissue of glucose-6-phosphate dehydrogenase (G-6-PD) mosaic hares fed 25-hydroxycholesterol or triol in addition to a high-cholesterol diet. Other hares fed the high-cholesterol diet witho...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90019-x

    authors： Lee KT,Janakidevi K,Kroms M,Schmee J,Thomas WA

    更新日期：1985-02-01 00:00:00

  • Accumulation of immune cells and high expression of chemokines/chemokine receptors in the upstream shoulder of atherosclerotic carotid plaques.

    abstract：:The presence of immune cells is important for plaque destabilization. Disturbed flow conditions were shown to enhance the recruitment of circulating immune cells. Thus, we analyzed in 54 atherosclerotic carotid plaques the frequency of different immune cells, HLA-DR, chemokines, and chemokine receptors, comparing the ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2006.10.008

    authors： Yilmaz A,Lipfert B,Cicha I,Schubert K,Klein M,Raithel D,Daniel WG,Garlichs CD

    更新日期：2007-06-01 00:00:00

  • Microvessel density as a molecular marker for identifying high-grade prostatic intraepithelial neoplasia precursors to prostate cancer.

    abstract：BACKGROUND:Existing clinical data have shown that high-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor to prostate cancer (CaP). Criteria to distinguish HGPIN that progress to CaP from those that do not remain poorly defined. Our objective was to evaluate microvessel density as a molecula...

    journal_title：Experimental and molecular pathology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.yexmp.2004.04.005

    authors： Sinha AA,Quast BJ,Reddy PK,Lall V,Wilson MJ,Qian J,Bostwick DG

    更新日期：2004-10-01 00:00:00

  • Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice.

    abstract：:Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(99)80003-3

    authors： Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

    更新日期：1999-02-01 00:00:00

  • Direct inhibitory effect of uremic toxins and polyamines on proliferation of VERO culture cells.

    abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1997.2215

    authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

    更新日期：1997-01-01 00:00:00

  • "Piecemeal" necrosis: renamed troxis necrosis.

    abstract：:Piecemeal necrosis, currently called interface hepatitis, is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis. The mechanism of liver cell loss and piecemeal necrosis needs to be determined. We hypothesize that piecemeal necrosis in hepatitis is due to a piecemeal removal of hepatocyte ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2397

    authors： Wang MX,Morgan T,Lungo W,Wang L,Sze GZ,French SW

    更新日期：2001-10-01 00:00:00

  • Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP.

    abstract：:Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma (DLBCL) p...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.yexmp.2015.08.019

    authors： Wong KK,Ch'ng ES,Loo SK,Husin A,Muruzabal MA,Møller MB,Pedersen LM,Pomposo MP,Gaafar A,Banham AH,Green TM,Lawrie CH

    更新日期：2015-12-01 00:00:00

  • MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy.

    abstract：:The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 eth...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2006.10.002

    authors： Rodríguez-Pérez JM,Fragoso JM,Alvarez-León E,Martínez-Rodríguez N,Gallardo GJ,Inés-Real S,Granados J,Reyes PA,Vargas-Alarcón G

    更新日期：2007-02-01 00:00:00

  • Respiratory reovirus 1/L induction of diffuse alveolar damage: a model of acute respiratory distress syndrome.

    abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2414

    authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

    更新日期：2002-02-01 00:00:00

  • The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.

    abstract：BACKGROUND:The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS:Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104272

    authors： El-Shazly SS,Hassan NM,Abdellateif MS,El Taweel MA,Abd-Elwahab N,Ebeid EN

    更新日期：2019-10-01 00:00:00

  • Gain of function p.E138A alteration in Card14 leads to psoriasiform skin inflammation and implicates genetic modifiers in disease severity.

    abstract：:Psoriasis (PS) is a common inflammatory and incurable skin disease affecting 2-3% of the human population. Although genome-wide association studies implicate more than 60 loci, the full complement of genetic factors leading to disease is not known. Rare, highly penetrant, gain-of-function, dominantly acting mutations ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104286

    authors： Sundberg JP,Pratt CH,Silva KA,Kennedy VE,Qin W,Stearns TM,Frost J,Sundberg BA,Bowcock AM

    更新日期：2019-10-01 00:00:00

  • Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer.

    abstract：:Although tumor surgery aims for a complete resection respecting tumor-specific safety distance, in many cases the most peripheral part, the invasion front, remains in situ. Tumor cells at the tumor margin lose epithelial properties and acquire features of mesenchymal cells. The process of epithelial-to-mesenchymal tra...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.09.003

    authors： Alkatout I,Wiedermann M,Bauer M,Wenners A,Jonat W,Klapper W

    更新日期：2013-02-01 00:00:00

  • Obliterative airway disease in rat tracheal allografts requires tumor necrosis factor alpha.

    abstract：:Obliterative bronchiolitis is the major complication affecting long-term lung transplant survivors. Tumor necrosis factor-alpha (TNF-alpha) promotes inflammation and fibrosis in chronic lung injury models. These experiments defined the role of TNF-alpha in an established model of obliterative airway disease (OAD). Rat...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.10.008

    authors： Farivar AS,Mackinnon-Patterson B,McCourtie AS,Namkung J,Ward PA,Mulligan MS

    更新日期：2005-06-01 00:00:00

  • Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats.

    abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2000.2346

    authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

    更新日期：2001-02-01 00:00:00