TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected].

abstract：:The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections were used to prepare tissue arrays to examine the intensity of fluorescence of IHC stained stem cell markers in liver tissue from malignant HCC tumors and accompa...

journal_title：Experimental and molecular pathology

authors： Buzzanco A,Gomez A,Rodriguez E,French BA,Tillman BA,Chang S,Ganapathy E,Junrungsee S,Zarrinpar A,Agopian VG,Naini BV,French SW Jr,French SW Sr

更新日期：2014-12-01 00:00:00

abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

journal_title：Experimental and molecular pathology

authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

更新日期：2003-08-01 00:00:00

abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

journal_title：Experimental and molecular pathology

authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

更新日期：1998-10-01 00:00:00

abstract：:Bezafibrate and clofibrate reduce the quantity of esterified cholesterol, decrease the incorporation of 14C-labeled oleic acid into cholesterol ester and inhibit acyl coenzyme A cholesterol acyltransferase activity in rabbit peritoneal macrophages stimulated with acetylated low density lipoprotein. In all cases, the e...

journal_title：Experimental and molecular pathology

authors： Hudson K,Mojumder S,Day AJ

更新日期：1983-02-01 00:00:00

abstract：:The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

journal_title：Experimental and molecular pathology

authors： Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) could differentiate into cardiomyocytes. In this study, we wished to determine whether we could improve ventricular function in a dilated cardiomyopathy (DCM) model in the rabbit by injecting stem cells directly into the ventricular wall. METHODS AND RESULTS:Japane...

journal_title：Experimental and molecular pathology

authors： Chen Y,Liu W,Li W,Gao C

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:This study was designed to investigate whether IL-17 can regulate the expression of the MMP/TIMP system, the OPG/RANK/RANKL system, or type-I and type-III collagen fibers in a rat model of isoproterenol-induced heart failure (HF). We also investigated the effect of IL-17 on myocardial fibrosis in this model. ...

journal_title：Experimental and molecular pathology

authors： Feng W,Li W,Liu W,Wang F,Li Y,Yan W

更新日期：2009-12-01 00:00:00

abstract：:Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin....

journal_title：Experimental and molecular pathology

authors： Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami A

更新日期：2003-06-01 00:00:00

abstract：:Quartz dust cytotoxicity was studied in starch-stimulated and nonstimulated mouse peritoneal macrophage cultures in vitro. Morphological changes, release of lactate dehydrogenase (LDH) into the culture medium, and lactate production were used as parameters of cell damage. Phagocytosis of quartz dust by macrophages inc...

journal_title：Experimental and molecular pathology

authors： Kaw JL

更新日期：1983-02-01 00:00:00

abstract：:Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma (DLBCL) p...

journal_title：Experimental and molecular pathology

authors： Wong KK,Ch'ng ES,Loo SK,Husin A,Muruzabal MA,Møller MB,Pedersen LM,Pomposo MP,Gaafar A,Banham AH,Green TM,Lawrie CH

更新日期：2015-12-01 00:00:00

abstract：:Granulomas, the pathologic hallmarks of tuberculosis, are composed of tightly numerous immune cells that respond to a variety of persistent stimuli during pathogen-host interaction. The granuloma is essential for host containment of mycobacterial infection, however, the mechanism of host and pathogen determinants to r...

journal_title：Experimental and molecular pathology

authors： Wang D,Zhou W,Lu S,Wang Q,Feng Y,Zhu G,Li L,Song Y,Gao Q

更新日期：2012-10-01 00:00:00

abstract：:An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

journal_title：Experimental and molecular pathology

authors： Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

更新日期：1989-06-01 00:00:00

abstract：:Ureaplasma urealyticum is a common inhabitant of mucosal surfaces but is also associated with a higher incidence of pneumonia and bronchopulmonary dysplasia in preterm infants. Culture and polymerase chain reaction demonstrate high isolation rates of ureaplasma in clinical specimens documenting their presence but do n...

journal_title：Experimental and molecular pathology

authors： Benstein BD,Crouse DT,Shanklin DR,Ourth DD

更新日期：2003-10-01 00:00:00

abstract：:Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones. Over the past decade many studies have revealed the r...

journal_title：Experimental and molecular pathology

authors： Bishop AJ,Schiestl RH

更新日期：2003-04-01 00:00:00

abstract：:5-Azacytidine (AZC) was studied in a lung cancer model in outbred and syngeneic (F1D) hamsters wherein benzol[a]pyrene (BP) from sustained release implants (SRI) induces preneoplastic mucosal changes which progress to bronchogenic cancer. In pilot studies to evaluate AZC toxicity, a dose schedule of 5 mg/kg biweekly w...

journal_title：Experimental and molecular pathology

authors： Hammond WG,Yellin A,Gabriel A,Paladugu RR,Azumi N,Hill LR,Benfield JR

更新日期：1990-08-01 00:00:00

abstract：:Severed tendons can undergo regenerative healing, intrinsic tendon repair. Fibrillogenesis of chick tendon involves "collagen fibril segments" (CFS), which are the building blocks of collagen fibers that make up tendon fascicles. The CFS are 10.5 micron in length, composed of tropocollagen monomers arranged in paralle...

journal_title：Experimental and molecular pathology

authors： Hazard SW,Myers RL,Ehrlich HP

更新日期：2011-12-01 00:00:00

abstract：:Studies of spontaneous mutations in mice have provided valuable disease models and important insights into the mechanisms of human disease. Ruffled (rul) is a new autosomal recessive mutation causing abnormal hair coat in mice. The rul allele arose spontaneously in the RB156Bnr/EiJ inbred mouse strain. In addition to ...

journal_title：Experimental and molecular pathology

authors： Herbert Pratt C,Potter CS,Fairfield H,Reinholdt LG,Bergstrom DE,Harris BS,Greenstein I,Dadras SS,Liang BT,Schofield PN,Sundberg JP

更新日期：2015-04-01 00:00:00

abstract：:To assess elastin biosynthesis in the aortic wall in response to acute elevation of blood pressure, we studied the aortic gene expression of tropoelastin in a rabbit midthoracic aortic coarctation model. The time points of the study were 1, 3, and 7 days and 2, 4, and 8 weeks after coarctation. Additional animals were...

journal_title：Experimental and molecular pathology

authors： Xu C,Zarins CK,Glagov S

更新日期：2002-04-01 00:00:00

abstract：:Osteonecrosis of the femoral head was produced in rats by cutting the ligamentum teres and incising the cervical periosteum. As of the second postoperative week, fibrous tissue pervaded the necrotic epiphyses, macrophages and osteoclasts removed the debris, osteoblasts deposited lamellar-fibred and woven-fibred intram...

journal_title：Experimental and molecular pathology

authors： Bejar J,Misselevich I,Peled E,Zinman C,Reis DN,Boss JH

更新日期：2005-04-01 00:00:00

abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

journal_title：Experimental and molecular pathology

authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

更新日期：1997-01-01 00:00:00

abstract：:Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of...

journal_title：Experimental and molecular pathology

authors： Bonita RE,Rose NR,Rasooly L,Caturegli P,Burek CL

更新日期：2002-12-01 00:00:00

abstract：:The testicular effects of daily oral dosing with two glycol ethers--either ethylene glycol monomethyl ether (EGM) or monoethyl ether (EGE) were studied in the prepubertal rat by histological examination of the testes. Over the 11-day dosing period studied, EGM was found to produce testicular damage at dose levels of a...

journal_title：Experimental and molecular pathology

authors： Creasy DM,Foster PM

更新日期：1984-04-01 00:00:00

abstract：:Plasmodium yoelii infection in albino mice decreased the activity of brain glutamic acid decarboxylase (GAD) by about 30 and 48% in crude homogenate and its synaptosomal fraction, respectively. The decrease was evident from 20% parasitemia and remained more or less constant up to 80% parasitemia. The Km values of GAD ...

journal_title：Experimental and molecular pathology

authors： Sharma MC,Tripathi LM,Dutta GP,Sagar P,Pandey VC

更新日期：1990-04-01 00:00:00

abstract：:We examined the correlation between elastolysis and abnormal accumulation of microfibrils in the arteries of rabbits using light and electron microscopic and tissue culture techniques. Partial constriction of the common carotid arteries of rabbits gave rise to gradual atrophy of the media with elastolysis and an unusu...

journal_title：Experimental and molecular pathology

authors： Katsuda S,Okada Y,Nakanishi I

更新日期：1990-02-01 00:00:00

abstract：:In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The ad...

journal_title：Experimental and molecular pathology

authors： Sandhir R,Gill KD

更新日期：1994-08-01 00:00:00

abstract：:We previously hypothesized that cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions. In this context we evaluated additional cases to further confirm that hypothesis. We report on 2 additional cases in which clonal cytogenetic abnormalities were observed in otherwise morpho...

journal_title：Experimental and molecular pathology

authors： Symons WA,Flynt FL,Mendiola C,Ortega V,Higgins RA,Velagaleti GV

更新日期：2013-02-01 00:00:00

abstract：:Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction, there is disagreement about the sensitivity of ischemic injury of an infarcted myocardium in experimental studies. The present study evaluated the influences of different durations of hyperglycemia on ischemic and reperfusio...

journal_title：Experimental and molecular pathology

authors： Xu G,Takashi E,Kudo M,Ishiwata T,Naito Z

更新日期：2004-02-01 00:00:00

abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

journal_title：Experimental and molecular pathology

authors： Russ AL,Haberstroh KM,Rundell AE

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The increased expression of the fibroblast growth factor receptor 4 (FGFR4) has been identified in many human cancers. Recently, a single nucleotide polymorphism changing the sense codon 388 from glycine to arginine was identified in the FGFR4 gene. The FGFR4 Arg(388) allele was found to be associated with a...

journal_title：Experimental and molecular pathology

authors： da Costa Andrade VC,Parise O Jr,Hors CP,de Melo Martins PC,Silva AP,Garicochea B

更新日期：2007-02-01 00:00:00

abstract：:Mucinous cystic neoplasms (MCN) and intraductal papillary mucinous neoplasms (IPMN) of the pancreas both appear to have been included and intermixed in some early reports of pancreatic cystic neoplasms. Recognition of their distinguishing features evolved during the last decade of the twentieth century. One legacy of ...

journal_title：Experimental and molecular pathology

authors： Baker ML,Seeley ES,Pai R,Suriawinata AA,Mino-Kenudson M,Zamboni G,Klöppel G,Longnecker DS

更新日期：2012-12-01 00:00:00