abstract：BACKGROUND:Prostate cancer is the most common cancer in men. A Notch signaling pathway is an important pathway in cell proliferation, differentiation, and fate. However, currently, the effects of abiraterone based-anti-androgene therapy and docetaxel, the most commonly used standard chemotherapy in prostate cancer trea...

journal_title：Experimental and molecular pathology

authors： Soylu H,Kırca M,Avcı S,Ozpolat B,Ustunel I

更新日期：2021-01-19 00:00:00

abstract：INTRODUCTION AND AIMS:Oxytocin (OT) is a neuropeptide hormone secreted by the posterior pituitary gland. Deficits in OT action have been observed in patients with behavioral and mood disorders, some of which correlate with an increased risk of cardiovascular disease (CVD). Recent research has revealed a wider systemic ...

journal_title：Experimental and molecular pathology

authors： Karten A,Vernice NA,Renna HA,Carsons SE,DeLeon J,Pinkhasov A,Gomolin IH,Glass DS,Reiss AB,Kasselman LJ

更新日期：2021-01-09 00:00:00

abstract：:Autoimmune thyroid disease (AITD) is a complex disorder with both genetic and environmental risk factors. A number of genetic factors such as HLA and CTLA-4 loci have been associated with risk of this disorder. In addition to these factors, recent studies have shown contribution of non-coding RNAs in the pathogenesis ...

journal_title：Experimental and molecular pathology

authors： Taheri M,Eghtedarian R,Dinger ME,Ghafouri-Fard S

更新日期：2020-12-01 00:00:00

abstract：:RNA binding motif protein 3 (RBM3) has been shown to be upregulated in several types of human tumors. Using tissue microarrays and immunohistochemistry, we showed here that both nuclear and cytoplasmic RBM3 expression levels were higher in hepatocellular carcinoma (HCC) tissues than in adjacent non-tumorous tissues. H...

journal_title：Experimental and molecular pathology

authors： Miao X,Zhang N

更新日期：2020-12-01 00:00:00

abstract：:Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment. Molecular research is a hot topic in modern hospitals, and long non-coding RNA (LncRNA) has been ...

journal_title：Experimental and molecular pathology

authors： Li G,Du P,Qiang X,Jin D,Liu H,Li B,Guo J

更新日期：2020-12-01 00:00:00

abstract：:The maintenance of homeostasis of the immune system depends on the balance between excitatory and inhibitory signals. Programmed death ligand (PD-L1) is a molecule which downregulates the immune system targeting the programmed death receptor 1 (PD-1). Under physiological conditions, the receptor is constitutively expr...

journal_title：Experimental and molecular pathology

authors： Kula A,Dawidowicz M,Kiczmer P,Prawdzic Seńkowska A,Świętochowska E

更新日期：2020-10-01 00:00:00

abstract：:One of the models that best explains the cellular heterogeneity observed in central nervous system (CNS) tumors is the presence of cancer stem cells (CSCs). CSCs can originate from differentiated adult cells that return to an undifferentiated stage through the mechanism known as epithelial-mesenchymal transition (EMT)...

journal_title：Experimental and molecular pathology

authors： Gonçalves BÔP,Fialho SL,Silvestrini BR,Sena IFG,Dos Santos GSP,Assis Gomes D,Silva LM

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

journal_title：Experimental and molecular pathology

authors： Tian RH,Guo KM,Han GH,Bai Y

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:Exosomes originated from mesenchymal stem cells (MSCs) benefit wound healing. This study investigated effects of exosomes originated from human umbilical cord MSCs (hUC-MSCs) on dermal fibroblasts-myofibroblasts transition via the TGF-β1/Smad2/3 signaling pathway. METHODS:Firstly, hUC-MSCs were collected and...

journal_title：Experimental and molecular pathology

authors： Hu J,Chen Y,Huang Y,Su Y

更新日期：2020-08-01 00:00:00

abstract：:Megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome is a developmental brain disorder characterized by an enlarged brain size with bilateral perisylvian polymicrogyria and a variable degree of ventriculomegaly. MPPH syndrome is associated with oromotor dysfunction, epilepsy, intellectual disability...

journal_title：Experimental and molecular pathology

authors： Szalai R,Melegh BI,Till A,Ripszam R,Csabi G,Acharya A,Schrauwen I,Leal SM,Komoly S,Kosztolanyi G,Hadzsiev K

更新日期：2020-08-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:Recent insights have implicated mesothelial-to-mesenchymal transition (MMT) as a mechanism by which mesothelial cells can transdifferentiate into cancer-associated fibroblasts (CAFs) in several cancers metastasizing to the peritoneum. However, this was not evaluated extensively in colorectal cancer. We examined the pr...

journal_title：Experimental and molecular pathology

authors： Demuytere J,Ceelen W,Van Dorpe J,Hoorens A

更新日期：2020-08-01 00:00:00

abstract：:Whatman FTA® cards provide the most reliable method for DNA storage and extraction, however, the literature lacks reports on the epigenetic analysis of FTA card-derived tumor DNA. Therefore, this study aimed at demonstrating that punches from colonic adenoma samples preserved on FTA filter cards are suitable for methy...

journal_title：Experimental and molecular pathology

authors： Buxhofer-Ausch V,Ausch C,Reiner A,Müllner-Ammer K,Schmid A,Kriwanek S,Sebesta C,Halwachs-Baumann G,Kriegshäuser G

更新日期：2020-06-01 00:00:00

abstract：:The kynurenine pathway (KP) has a principal role in the metabolism of tryptophan. This pathway is also involved in the pathogenesis of cancer. We evaluated expression of two rate limiting enzymes from this pathway (IDO1 and TDO2) as well as three long non-coding RNAs (lncRNAs) that have been predicted to alter express...

journal_title：Experimental and molecular pathology

authors： Ghafouri-Fard S,Taherian-Esfahani Z,Dashti S,Kholghi Oskooei V,Taheri M,Samsami M

更新日期：2020-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

journal_title：Experimental and molecular pathology

authors： Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

更新日期：2020-06-01 00:00:00

abstract：:The morphology of Gleason 4 prostate cancer (PCa) can be subdivided into cribriform and non-cribriform patterns. A large body of evidence has shown that pattern 4 cribriform PCa (especially non-glomeruloid type) is associated with adverse pathologic features and clinical outcomes compared with non-cribriform pattern 4...

journal_title：Experimental and molecular pathology

authors： Xiao GQ,Nguyen E,Unger PD,Sherrod AE

更新日期：2020-06-01 00:00:00

abstract：:As the number of elderly patients increases, some patients with heart problems may also need surgery. The purpose of this study was to investigate whether dexmedetomidine (DEX), a common used anesthetic, was beneficial to the patients with heart problems. Myocardial cells induced by doxorubicin (DOX) was to simulate t...

journal_title：Experimental and molecular pathology

authors： He Y,Yang Z,Li J,Li E

更新日期：2020-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the progress in screening and treatment, CRC remains a leading cause of cancer-related mortality. Alterations to normal nucleic acid processing may drive neoplastic transformation of colorectal epithelium. DNA repair machinery performs an es...

journal_title：Experimental and molecular pathology

authors： Al-Shaheri FN,Al-Shami KM,Gamal EH,Mahasneh AA,Ayoub NM

更新日期：2020-04-01 00:00:00

abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

journal_title：Experimental and molecular pathology

authors： Li H,Piao L,Xu D,Xuan Y

更新日期：2020-02-01 00:00:00

abstract：:Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioma. However, its role and molecular mechanism in glioma have not been completely elucidated. Immunohistochemistry analyses of EGFRvIII, enhancer of zeste homolog 2 (EZH2) and aplysia ras homolog I (ARHI) were p...

journal_title：Experimental and molecular pathology

authors： Zheng Y,Ma Y,Yue H,Liu G,Han S

更新日期：2020-02-01 00:00:00

abstract：:Lung Adenocarcinoma is one of the most leading causes of death worldwide. Early detection of this cancer could enhance the survival chance of patients and even lead to better and more effective treatment. One of the approaches to find out more about biological malfunctions is using "omics" data. Among diverse computat...

journal_title：Experimental and molecular pathology

authors： Haghjoo N,Moeini A,Masoudi-Nejad A

更新日期：2020-02-01 00:00:00

abstract：:Ketamine is widely used both as anesthetic and abuse drug. In this study, we investigated the effects of a wide range of ketamine concentrations (100-500-1000 μM) on calcium mobilization and the induction of cell death in undifferentiated PC12 cells, 24 h after treatment. Calcium mobilization was measured as the perce...

journal_title：Experimental and molecular pathology

authors： Bustamante J,Acosta L,Karadayian AG,Lores-Arnaiz S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to be critical in the onset and progression of acute myocardial ischemia (AMI). This study attempted to reveal the biological function of MALAT1 in AMI. METHODS:Expression of MALAT1 in H9c2 cells was silenced by shRNA-mediated...

journal_title：Experimental and molecular pathology

authors： Gong L,Chang H,Xu H

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS:Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and ...

journal_title：Experimental and molecular pathology

authors： El-Shazly SS,Hassan NM,Abdellateif MS,El Taweel MA,Abd-Elwahab N,Ebeid EN

更新日期：2019-10-01 00:00:00

abstract：:Psoriasis (PS) is a common inflammatory and incurable skin disease affecting 2-3% of the human population. Although genome-wide association studies implicate more than 60 loci, the full complement of genetic factors leading to disease is not known. Rare, highly penetrant, gain-of-function, dominantly acting mutations ...

journal_title：Experimental and molecular pathology

authors： Sundberg JP,Pratt CH,Silva KA,Kennedy VE,Qin W,Stearns TM,Frost J,Sundberg BA,Bowcock AM

更新日期：2019-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in ...

journal_title：Experimental and molecular pathology

authors： Ge H,Yan Z,Zhu H,Zhao H

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Calcific tendinopathy (CT) is characterized by deposits of calcium, most commonly found in the shoulder tendons. The exact cause and pathogenesis of CT are not fully understood. This study analyzed the expression pattern of RNA-binding protein fox-1 homolog 2 (RBFOX2), a crucial splicing regulator in tissue ...

journal_title：Experimental and molecular pathology

authors： Cho N,Kim JO,Lee S,Choi S,Kim J,Ko MS,Park SJ,Ji JH,Kim KK

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To identify the relationship between clinical pathological characteristics and the recurrence score (RS) on a 21-gene expression assay in patients with hormone receptor-positive, node-negative breast cancer, as well as the effect of RS on adjuvant decision-making. METHODS:The retrospective study was conducte...

journal_title：Experimental and molecular pathology

authors： Yu-Qing Y,Lei W,Mei-Ling H,Jing-Jing X,Mei-Chen W,Jiang W,Jun-Sheng H,Rui L,Nan-Lin L

更新日期：2019-06-01 00:00:00

abstract：:As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibro...

journal_title：Experimental and molecular pathology

authors： Jia Y,Ji P,French B,Tillman B,French SW

更新日期：2019-06-01 00:00:00

abstract：:Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor im...

journal_title：Experimental and molecular pathology

authors： Sakiyama MJ,Espinoza I,Reddy A,de Carlo F,Kumar A,Levenson AS,Bae S,Zhou X,Claudio PP,Lewin J,Manucha V,Pound CR,Vijayakumar S,Gomez CR

更新日期：2019-06-01 00:00:00

abstract：:Ketamine, a common N-methyl-d-aspartate receptor (NMDAR) antagonist, is an option for cancer pain treatment in clinical practice. Ketamine has been shown to have the capacity to attenuate cancer cells malignancy. However, the underlying mechanism remains elusive. In the present study, we reported that ketamine inhibit...

journal_title：Experimental and molecular pathology

authors： Duan W,Hu J,Liu Y

更新日期：2019-04-01 00:00:00

abstract：:Invadopodia, cancer cell protrusions with proteolytic activity, are functionally associated with active remodeling of the extracellular matrix. Here, we show that the invadopodia-related protein TKS5 is expressed in human pancreatic adenocarcinoma lines, and demonstrate that pancreatic cancer cells depend on TKS5 for ...

journal_title：Experimental and molecular pathology

authors： Chen YC,Baik M,Byers JT,Chen KT,French SW,Díaz B

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid. METH...

journal_title：Experimental and molecular pathology

authors： Ahmad F,Nathani R,Venkat J,Bharda A,Vanere V,Bhatia S,Das BR

更新日期：2018-12-01 00:00:00

abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...

journal_title：Experimental and molecular pathology

authors： McNulty SN,Schwetye K,Goldstein M,Carter J,Schmidt RE,Ansstas G,Tsien CI,Kim AH,Dahiya S

更新日期：2018-12-01 00:00:00

abstract：:We have previously shown that SIRT1 mRNA expression was significantly lower in relapsing MS patients compared to those in remission. Our goal was to longitudinally investigate the role of active, phosphorylated SIRT1 (p-SIRT1) as a potential biomarker of relapse and predictor for response to glatiramer acetate (GA) tr...

journal_title：Experimental and molecular pathology

authors： Ciriello J,Tatomir A,Hewes D,Boodhoo D,Anselmo F,Rus V,Rus H

更新日期：2018-10-01 00:00:00

abstract：:Lymph node involvement of chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is characterised by the diffuse infiltration of small neoplastic lymphocytes, which is accompanied by the presence of proliferation centres (PCs) comprising prolymphocytes and paraimmunoblasts. There is increasing evidence of ...

journal_title：Experimental and molecular pathology

authors： Szurián K,Csala I,Marosvári D,Rajnai H,Dezső K,Bödör C,Piurkó V,Matolcsy A,Reiniger L

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers totally la...

journal_title：Experimental and molecular pathology

authors： Nottegar A,Tabbò F,Luchini C,Guerrera F,Gaudiano M,Bria E,Brunelli M,Chilosi M,Inghirami G

更新日期：2017-04-01 00:00:00

abstract：:Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 pri...

journal_title：Experimental and molecular pathology

authors： Reddy HS,Keene CD,Chang SH,Jian-Amadi A,Cimino PJ

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Tumor surgery is aimed at complete resection of the lesion while ensuring a sufficient tumor-specific safety distance. Nevertheless, in many cases the most peripheral part - the invasion front - remains in situ. Tumor cells at the tumor margin have been reported to lose their epithelial properties and acquire f...

journal_title：Experimental and molecular pathology

authors： Alkatout I,Hübner F,Wenners A,Hedderich J,Wiedermann M,Sánchez C,Röcken C,Mathiak M,Maass N,Klapper W

更新日期：2017-04-01 00:00:00

abstract：:Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as t...

journal_title：Experimental and molecular pathology

authors： Hu JM,Liu K,Liu JH,Jiang XL,Wang XL,Yang L,Chen YZ,Liu CX,Li SG,Cui XB,Zou H,Pang LJ,Zhao J,Qi Y,Liang WH,Yuan XL,Li F

更新日期：2017-02-01 00:00:00