Abstract：
:Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin. In this report we strengthen this evidence, showing that Lewis rats immunized with purified skeletal muscle myosin develop EAM with the same pattern and severity as EAM induced by whole rabbit skeletal muscle homogenate (WRM). Multiple inflammatory lesions are detected histopathologically in the biceps, quadriceps, and gastrocnemius muscles. Myosin-reactive T cells from animals immunized either with myosin or with WRM have similar patterns of antigen-induced proliferation. The results show that myosin, a component of skeletal muscle, is at least one autoantigen in EAM.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami Adoi
10.1016/s0014-4800(03)00003-0keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
238-43issue
3eissn
0014-4800issn
1096-0945pii
S0014480003000030journal_volume
74pub_type
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