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Melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine genes incorporated into an African green monkey simian cytomegalovirus-derived stealth virus.

Abstract：

:DNA isolated from the culture of an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus has been cloned. A region of the virus that contains genes coding proteins homologous to the UL141, UL144, and UL145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several distinct copies of the melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine gene. This finding illustrates the capacity of stealth viruses to capture, amplify, and mutate genes with potential oncogenic activity. The lack of introns in the assimilated cellular genes indicates a role for reverse transcription in the assembly of stealth viruses.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Martin WJ

doi

10.1006/exmp.1999.2240

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

15-8

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014480099922402

journal_volume

66

pub_type

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