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Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease.

Abstract：

:The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury in organs typically involved in human acute GVHD (skin, liver) and less typically involved organs (spleen, kidney, lung). Mice were assessed histologically at early (2 weeks), intermediate (3 months) and late (6 month) time points. Based on the emerging roles of Fas ligand killing and complement deposition in allograft rejection, we correlated the amount of tissue specific TUNEL positive apoptosis and deposition of complement (C5b-9) with histopathologic changes. Our results indicate a striking similarity histologically between acute GVHD occurring in this model and in humans following bone marrow transplant. Moreover, C5b-9 deposition and apoptotic cell accumulation were found to parallel tissue injury in major organs of acute GVHD mice, although not all organs exhibited the same kinetic pattern. These results indicate a role for both adaptive immunity and innate immunity in this model of GVHD and support its use in modeling human acute GVHD in the nonmyeloablative setting.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

doi

10.1016/j.yexmp.2005.03.007

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

136-45

issue

2

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(05)00062-6

journal_volume

79

pub_type

杂志文章

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