当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF alpha messenger RNA.

Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF alpha messenger RNA.

Abstract：

:We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oil, and fish oil) with ethanol; control rats were fed isocaloric amounts of dextrose instead of ethanol. At sacrifice the following were evaluated: liver pathologic changes, TNF-alpha mRNA by reverse transcription-PCR, plasma endotoxin, and ICAM-1 by immunohistochemistry and immunoblot analysis. Upregulation of ICAM-1 in endothelial lining cells in central and portal veins was observed in rats showing evidence of pathologic changes. Rats fed fish oil and ethanol, which exhibited the most severe inflammation, also showed hepatocyte ICAM-1 staining. The presence of ICAM-1 staining, in general, correlated with the level of TNF-alpha mRNA expression and plasma endotoxin levels. Upregulation of ICAM-1 in rats fed ethanol may contribute to the inflammatory changes seen in this model. The association between ICAM-1 upregulation and endotoxin and TNF-alpha mRNA suggests a role for these mediators in the inflammatory process in alcoholic liver injury.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

doi

10.1006/exmp.1995.1005

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

42-51

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(85)71005-2

journal_volume

62

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Restoration of chemosensitivity in cancer cells with MDR phenotype by deoxyribozyme, compared with ribozyme.

    abstract：:One of the main mechanisms for multidrug resistance (MDR) involves multidrug resistance gene 1 (MDR1) which encodes P-glycoprotein (Pgp). Pgp acts as a drug efflux pump and exports chemotherapeutic agents from cancer cells. Specific inhibition of Pgp expression by gene therapy is considered a well-respective strategy ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.03.004

    authors： Xing AY,Shi DB,Liu W,Chen X,Sun YL,Wang X,Zhang JP,Gao P

    更新日期：2013-06-01 00:00:00

  • Molecular evaluation of BRAF gene mutation in thyroid tumors: Significant association with papillary tumors and extra thyroidal extension indicating its role as a biomarker of aggressive disease.

    abstract：BACKGROUND:Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid. METH...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2018.11.002

    authors： Ahmad F,Nathani R,Venkat J,Bharda A,Vanere V,Bhatia S,Das BR

    更新日期：2018-12-01 00:00:00

  • Sequential change of DNA synthesis in cultured aortic smooth muscle cells stimulated by hyperlipidemic serum.

    abstract：:Smooth muscle cells from monkey aorta quiescent in 5% calf serum have been shown to be stimulated to renewed proliferation by hyperlipidemic serum or LDL from such serum. This proliferative response evidently is not dependent on platelet-derived growth factor present in our system in large quantities. The least exposu...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90043-3

    authors： Mitsumata M,Fischer-Dzoga K,Getz GS,Wissler RW

    更新日期：1988-02-01 00:00:00

  • Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes.

    abstract：:It is well-known that leukemic cells of overt leukemia (OL) that have transformed from myelodysplastic syndromes (MDS) are more resistant to chemotherapy as compared with de novo AML cells. Thus, to examine the expression levels of drug-resistant genes and their alterations with the development of OL in MDS, the expre...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2006.01.004

    authors： Kurata M,Hasegawa M,Nakagawa Y,Abe S,Yamamoto K,Suzuki K,Kitagawa M

    更新日期：2006-12-01 00:00:00

  • The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.

    abstract：:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins cou...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2016.03.010

    authors： French SW,Mendoza AS,Peng Y

    更新日期：2016-06-01 00:00:00

  • Obliterative airway disease in rat tracheal allografts requires tumor necrosis factor alpha.

    abstract：:Obliterative bronchiolitis is the major complication affecting long-term lung transplant survivors. Tumor necrosis factor-alpha (TNF-alpha) promotes inflammation and fibrosis in chronic lung injury models. These experiments defined the role of TNF-alpha in an established model of obliterative airway disease (OAD). Rat...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.10.008

    authors： Farivar AS,Mackinnon-Patterson B,McCourtie AS,Namkung J,Ward PA,Mulligan MS

    更新日期：2005-06-01 00:00:00

  • Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile.

    abstract：:Paraoxonase gene polymorphisms (PON1-55 and PON1-192) were determined in four Mexican populations (Mestizos, Nahuas, Teenek and Mayos) belonging to different ethnic groups. The role of these polymorphisms in the lipid profile in the Mestizo group was also analyzed. PON1 polymorphisms were determined by polymerase chai...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.05.006

    authors： Gamboa R,Zamora J,Rodríguez-Pérez JM,Fragoso JM,Cardoso G,Posadas-Romero C,Vargas-Alarcón G

    更新日期：2006-02-01 00:00:00

  • Low-density lipoprotein endocytosis. II. Influence of the multivalent ligand cationized ferritin on acetylated low-density lipoprotein endocytosis in cultured cells.

    abstract：:Interactions of the basic multivalent ligand cationized ferritin (CF) with cultured cells markedly alter their endocytic function. In this study, the influence of CF treatment on the binding, internalization, and degradation of chemically modified (acetylated) low-density lipoproteins (Ac-LDL) was examined in aortic s...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90072-x

    authors： Sprague EA,Edwards EH,Valente AJ,Suenram CA,Kerbacher JJ,Schwartz CJ

    更新日期：1988-06-01 00:00:00

  • Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.

    abstract：:Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day). Diarrhea also occurred in monkeys after 1 week ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(83)90059-x

    authors： Yarrington JT,Sprinkle DJ,Loudy DE,Diekema KA,McCann PP,Gibson JP

    更新日期：1983-12-01 00:00:00

  • Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper.

    abstract：:The pathogenesis of skeletal muscle necrosis induced by crude Bothrops asper venom and isolated myotoxic phospholipase was studied using light and electron microscopy. White mice were injected intramuscularly with a dose of 2.5 micrograms/g and tissue samples were taken at 30 min and 1, 3, 6, 12, 24, and 48 hr. Toxin-...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90054-6

    authors： Gutiérrez JM,Ownby CL,Odell GV

    更新日期：1984-06-01 00:00:00

  • Pulmonary toxicity of cyclophosphamide: a 1-year study.

    abstract：:The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90031-0

    authors： Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

    更新日期：1985-04-01 00:00:00

  • Effect of Plasmodium yoelii infection on GABA metabolism of mouse brain.

    abstract：:Plasmodium yoelii infection in albino mice decreased the activity of brain glutamic acid decarboxylase (GAD) by about 30 and 48% in crude homogenate and its synaptosomal fraction, respectively. The decrease was evident from 20% parasitemia and remained more or less constant up to 80% parasitemia. The Km values of GAD ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(90)90009-3

    authors： Sharma MC,Tripathi LM,Dutta GP,Sagar P,Pandey VC

    更新日期：1990-04-01 00:00:00

  • Spiroplasma spp. biofilm formation is instrumental for their role in the pathogenesis of plant, insect and animal diseases.

    abstract：:Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.04.017

    authors： Bastian FO,Elzer PH,Wu X

    更新日期：2012-08-01 00:00:00

  • The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis.

    abstract：:Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as t...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.12.001

    authors： Hu JM,Liu K,Liu JH,Jiang XL,Wang XL,Yang L,Chen YZ,Liu CX,Li SG,Cui XB,Zou H,Pang LJ,Zhao J,Qi Y,Liang WH,Yuan XL,Li F

    更新日期：2017-02-01 00:00:00

  • Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

    abstract：:RNA binding motif protein 3 (RBM3) has been shown to be upregulated in several types of human tumors. Using tissue microarrays and immunohistochemistry, we showed here that both nuclear and cytoplasmic RBM3 expression levels were higher in hepatocellular carcinoma (HCC) tissues than in adjacent non-tumorous tissues. H...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104546

    authors： Miao X,Zhang N

    更新日期：2020-12-01 00:00:00

  • Invasive mucinous cystic neoplasms of the pancreas.

    abstract：:Mucinous cystic neoplasms (MCN) and intraductal papillary mucinous neoplasms (IPMN) of the pancreas both appear to have been included and intermixed in some early reports of pancreatic cystic neoplasms. Recognition of their distinguishing features evolved during the last decade of the twentieth century. One legacy of ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.07.005

    authors： Baker ML,Seeley ES,Pai R,Suriawinata AA,Mino-Kenudson M,Zamboni G,Klöppel G,Longnecker DS

    更新日期：2012-12-01 00:00:00

  • Direct inhibitory effect of uremic toxins and polyamines on proliferation of VERO culture cells.

    abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1997.2215

    authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

    更新日期：1997-01-01 00:00:00

  • NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins.

    abstract：:Oral cancer is a major health problem in many parts of the world including India. The molecular mechanisms involved in oral tumorigenesis are not completely understood. Although surgery continues to be the most common treatment modality for this cancer, survival rates of oral cancer patients have still not significant...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2006.05.001

    authors： Santhi WS,Sebastian P,Varghese BT,Prakash O,Pillai MR

    更新日期：2006-10-01 00:00:00

  • Mechanisms by which acute phase proteins enhance development of liver fibrosis: effects on collagenase and prolyl-4-hydroxylase activity in the rat liver.

    abstract：:Previous experiments showed that the presence of high levels of acute phase reactants (APR) enhance CCl4-induced liver fibrosis in the rat. A high correlation was found between the degree of fibrosis and alpha 2-macroglobulin of the rat (alpha 2-macrofetoprotein, alpha M-FP) used for monitoring the acute phase respons...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(86)90056-0

    authors： van Gool J,de Nie I,Smit J,Zuyderhoudt FM

    更新日期：1986-10-01 00:00:00

  • Extracellular and cell-associated localizations of plasminogen activators and plasminogen activator inhibitor-1 in cultured endothelium.

    abstract：:The extracellular localizations of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) were examined in cultured bovine capillary endothelial cells (BCEs) by an immunofluorescence method using BCEs treated with or without saponin and focal ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(91)90046-z

    authors： Murata T,Nakashima Y,Yasunaga C,Maeda K,Sueishi K

    更新日期：1991-10-01 00:00:00

  • IDH1 mutations in gliomas: first series from a tertiary care centre in India with comprehensive review of literature.

    abstract：OBJECT:Mutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2011.04.017

    authors： Jha P,Suri V,Sharma V,Singh G,Sharma MC,Pathak P,Chosdol K,Jha P,Suri A,Mahapatra AK,Kale SS,Sarkar C

    更新日期：2011-08-01 00:00:00

  • EGFRvIII epigenetically regulates ARHI to promote glioma cell proliferation and migration.

    abstract：:Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioma. However, its role and molecular mechanism in glioma have not been completely elucidated. Immunohistochemistry analyses of EGFRvIII, enhancer of zeste homolog 2 (EZH2) and aplysia ras homolog I (ARHI) were p...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104344

    authors： Zheng Y,Ma Y,Yue H,Liu G,Han S

    更新日期：2020-02-01 00:00:00

  • Spectrin oligomerization is cooperatively coupled to membrane assembly: a linkage targeted by many hereditary hemolytic anemias?

    abstract：:In the erythrocyte, ankyrin is the major adapter protein linking tetramers of band 3 to the spectrin-actin cytoskeleton. This linkage involves a direct interaction between ankyrin and the 14th-15th repeat unit of beta-spectrin. The spectrin cytoskeleton itself is stabilized by the self-association of spectrin heterodi...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2377

    authors： Giorgi M,Cianci CD,Gallagher PG,Morrow JS

    更新日期：2001-06-01 00:00:00

  • Isolation and characterization of crinosomes--a subclass of secondary lysosomes.

    abstract：:A technique is presented for isolating a subclass of lysosomes, designated crinosomes, by one-step floating-up centrifugation in a cesium-containing sucrose gradient. Rats were treated with vinblastine in order to induce the formation of crinosomes. Vinblastine blocked exocytosis of secretory granules at the cell bord...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(89)90028-2

    authors： Glaumann H,Ahlberg J,Hultenby K,Jansson H,Mengarelli-Widholm S,Motakefi AM

    更新日期：1989-04-01 00:00:00

  • WITHDRAWN: Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosis.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.05.003

    authors： Wu N,Zhang X,Jia P,Jia D

    更新日期：2015-05-07 00:00:00

  • EGFR ligands exert diverging effects on male reproductive organs.

    abstract：:While the EGFR and most of its ligands are expressed in the male reproductive tract, their functions in male reproduction are poorly understood. Interestingly, male transgenic mice overexpressing EGF are sterile, and transgenic mice overexpressing TGFA, another EGFR ligand, show an enlarged coagulation gland (anterior...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.11.005

    authors： Schneider MR,Gratao AA,Dahlhoff M,Boersma A,Hrabé de Angelis M,Hoang-Vu C,Wolf E,Klonisch T

    更新日期：2010-02-01 00:00:00

  • Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.

    abstract：:Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 pri...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2017.01.016

    authors： Reddy HS,Keene CD,Chang SH,Jian-Amadi A,Cimino PJ

    更新日期：2017-04-01 00:00:00

  • Low-expressed GAS5 injure myocardial cells and progression of chronic heart failure via regulation of miR-223-3P.

    abstract：:Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment. Molecular research is a hot topic in modern hospitals, and long non-coding RNA (LncRNA) has been ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104529

    authors： Li G,Du P,Qiang X,Jin D,Liu H,Li B,Guo J

    更新日期：2020-12-01 00:00:00

  • Effect of acute plasma fibronectin depletion on tissue fibronectin levels: analysis by a new fluorescent immunoassay.

    abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90010-8

    authors： Saba TM,Cho E,Blumenstock FA

    更新日期：1984-08-01 00:00:00

  • Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome.

    abstract：:We tested the hypothesis that structural changes in the genome parallel age- and organ-specific phenotypes in conjunction with the differential transposition activities of retroelements. The genomes of the liver from C57BL/6J mice were larger than other organs, coinciding with an increase in genomic copies of certain ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.04.013

    authors： Lee KH,Chiu S,Lee YK,Greenhalgh DG,Cho K

    更新日期：2012-08-01 00:00:00