Abstract：
:While the EGFR and most of its ligands are expressed in the male reproductive tract, their functions in male reproduction are poorly understood. Interestingly, male transgenic mice overexpressing EGF are sterile, and transgenic mice overexpressing TGFA, another EGFR ligand, show an enlarged coagulation gland (anterior prostate) due to severe hyperplasia with focal dysplasia. We studied the male reproductive tract of transgenic mice overexpressing betacellulin (BTC-tg) under the control of a promoter conferring widespread transgene expression. Despite strong overexpression of BTC in different parts of the male reproductive tract, the gross appearance and histology of the reproductive organs of BTC-tg males were normal and the same were true for sperm parameters and the in vitro fertilization rate. Collectively, our findings demonstrate that excess of BTC exerts no deleterious effects on the structure or function of the male reproductive tract in mice and indicates unique, non-overlapping functions of specific EGFR ligands in male reproduction.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Schneider MR,Gratao AA,Dahlhoff M,Boersma A,Hrabé de Angelis M,Hoang-Vu C,Wolf E,Klonisch Tdoi
10.1016/j.yexmp.2009.11.005subject
Has Abstractpub_date
2010-02-01 00:00:00pages
216-8issue
1eissn
0014-4800issn
1096-0945pii
S0014-4800(09)00162-2journal_volume
88pub_type
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journal_title：Experimental and molecular pathology
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journal_title：Experimental and molecular pathology
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pub_type： 杂志文章,多中心研究
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journal_title：Experimental and molecular pathology
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更新日期：1989-06-01 00:00:00
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更新日期：2021-01-19 00:00:00
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journal_title：Experimental and molecular pathology
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更新日期：2015-06-01 00:00:00
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journal_title：Experimental and molecular pathology
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
doi：10.1016/j.yexmp.2005.04.004
更新日期：2005-08-01 00:00:00
abstract：:The morphology of Gleason 4 prostate cancer (PCa) can be subdivided into cribriform and non-cribriform patterns. A large body of evidence has shown that pattern 4 cribriform PCa (especially non-glomeruloid type) is associated with adverse pathologic features and clinical outcomes compared with non-cribriform pattern 4...
journal_title：Experimental and molecular pathology
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