Integrin characterization in pulmonary bronchioles.

abstract：:This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic ste...

journal_title：Experimental and molecular pathology

authors： Neuman MG,French SW,French BA,Seitz HK,Cohen LB,Mueller S,Osna NA,Kharbanda KK,Seth D,Bautista A,Thompson KJ,McKillop IH,Kirpich IA,McClain CJ,Bataller R,Nanau RM,Voiculescu M,Opris M,Shen H,Tillman B,Li J,Liu H

更新日期：2014-12-01 00:00:00

abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

journal_title：Experimental and molecular pathology

authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

更新日期：2007-12-01 00:00:00

abstract：:Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

journal_title：Experimental and molecular pathology

authors： Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

更新日期：1999-02-01 00:00:00

abstract：:The Chediak-Higashi syndrome (CHS) is an inherited disorder of humans and of several animal species, characterized by partial albinism, pseudohemophilia, increased susceptibility to disease, and large inclusions in all granule-forming cells. In this study, various parameters of adenine nucleotide biochemistry were exa...

journal_title：Experimental and molecular pathology

authors： Jamison KC,Padgett GA,Giesy JP,Bell TG

更新日期：1993-02-01 00:00:00

abstract：:Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioma. However, its role and molecular mechanism in glioma have not been completely elucidated. Immunohistochemistry analyses of EGFRvIII, enhancer of zeste homolog 2 (EZH2) and aplysia ras homolog I (ARHI) were p...

journal_title：Experimental and molecular pathology

authors： Zheng Y,Ma Y,Yue H,Liu G,Han S

更新日期：2020-02-01 00:00:00

abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

journal_title：Experimental and molecular pathology

authors： Russ AL,Haberstroh KM,Rundell AE

更新日期：2007-10-01 00:00:00

abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

journal_title：Experimental and molecular pathology

authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

更新日期：2001-02-01 00:00:00

abstract：:Thrombospondin 2 (TSP2) is a protein with important roles in different tumor types, mainly related to tumor inhibition. However, there are limiting data regarding TSP2 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH). We aimed to investigate TSP2 transcript and protein expression in tumoral and non-tumo...

journal_title：Experimental and molecular pathology

authors： Matos AR,Coutinho-Camillo CM,Thuler LC,Fonseca FP,Soares FA,Silva EA,Gimba ER

更新日期：2013-06-01 00:00:00

abstract：:The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and...

journal_title：Experimental and molecular pathology

authors： Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

更新日期：1985-04-01 00:00:00

abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

journal_title：Experimental and molecular pathology

authors： Haywood S,Loughran M,Batt RM

更新日期：1985-10-01 00:00:00

abstract：:In the erythrocyte, ankyrin is the major adapter protein linking tetramers of band 3 to the spectrin-actin cytoskeleton. This linkage involves a direct interaction between ankyrin and the 14th-15th repeat unit of beta-spectrin. The spectrin cytoskeleton itself is stabilized by the self-association of spectrin heterodi...

journal_title：Experimental and molecular pathology

authors： Giorgi M,Cianci CD,Gallagher PG,Morrow JS

更新日期：2001-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

journal_title：Experimental and molecular pathology

authors： Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

更新日期：2020-06-01 00:00:00

abstract：:Piecemeal necrosis, currently called interface hepatitis, is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis. The mechanism of liver cell loss and piecemeal necrosis needs to be determined. We hypothesize that piecemeal necrosis in hepatitis is due to a piecemeal removal of hepatocyte ...

journal_title：Experimental and molecular pathology

authors： Wang MX,Morgan T,Lungo W,Wang L,Sze GZ,French SW

更新日期：2001-10-01 00:00:00

abstract：:The purpose of the study was to determine the temporal relationship between lymphocyte activating factor (LAF) activity and the acute-phase response, as measured by plasma fibronectin (Fn), C-reactive protein (CRP), and albumin levels in adjuvant arthritic rats. LAF activity as measured in the thymocyte costimulator a...

journal_title：Experimental and molecular pathology

authors： Connolly KM,Stecher VJ,Allin S,LaBrie T

更新日期：1988-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:We have analyzed the localization of dendritic cells (DCs) in non-lesional gray matter (NLGM) in comparison to non-lesional white matter (NLWM) and acute or chronic active multiple sclerosis (MS) lesions. Immunohistochemistry was performed on cryostat sections for DCs markers (CD209, CD205, CD83) and other markers for...

journal_title：Experimental and molecular pathology

authors： Cudrici C,Ito T,Zafranskaia E,Niculescu F,Mullen KM,Vlaicu S,Judge SI,Calabresi PA,Rus H

更新日期：2007-10-01 00:00:00

abstract：:Ketamine is widely used both as anesthetic and abuse drug. In this study, we investigated the effects of a wide range of ketamine concentrations (100-500-1000 μM) on calcium mobilization and the induction of cell death in undifferentiated PC12 cells, 24 h after treatment. Calcium mobilization was measured as the perce...

journal_title：Experimental and molecular pathology

authors： Bustamante J,Acosta L,Karadayian AG,Lores-Arnaiz S

更新日期：2019-12-01 00:00:00

abstract：:Breast cancer (BC) is a major health problem for women around the world. Although advances in the field of molecular therapy have been achieved, the successful therapeutic management of BC, particularly metastatic disease, remains a challenge for patients and clinicians. One of the areas of current investigation is th...

journal_title：Experimental and molecular pathology

authors： Ejaeidi AA,Craft BS,Puneky LV,Lewis RE,Cruse JM

更新日期：2015-08-01 00:00:00

abstract：:Growth and differentiation factor-5 (GDF-5) is a member of the TGF-ß superfamily which regulates cell division and differentiation. GDF-5 attracted high interest because of its role in skeletal development, especially in cartilaginous sites. Little is known, however, about the role of GFD-5 in disc cell biology. The p...

journal_title：Experimental and molecular pathology

authors： Gruber HE,Hoelscher GL,Ingram JA,Bethea S,Hanley EN Jr

更新日期：2014-04-01 00:00:00

abstract：:Bezafibrate and clofibrate reduce the quantity of esterified cholesterol, decrease the incorporation of 14C-labeled oleic acid into cholesterol ester and inhibit acyl coenzyme A cholesterol acyltransferase activity in rabbit peritoneal macrophages stimulated with acetylated low density lipoprotein. In all cases, the e...

journal_title：Experimental and molecular pathology

authors： Hudson K,Mojumder S,Day AJ

更新日期：1983-02-01 00:00:00

abstract：:An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

journal_title：Experimental and molecular pathology

authors： Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

更新日期：1989-06-01 00:00:00

abstract：:The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of st...

journal_title：Experimental and molecular pathology

authors： Oren A,Ganz T,Liu L,Meerloo T

更新日期：2003-04-01 00:00:00

abstract：:The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury...

journal_title：Experimental and molecular pathology

authors： Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

更新日期：2005-10-01 00:00:00

abstract：:We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we de...

journal_title：Experimental and molecular pathology

authors： Tegla CA,Cudrici CD,Nguyen V,Danoff J,Kruszewski AM,Boodhoo D,Mekala AP,Vlaicu SI,Chen C,Rus V,Badea TC,Rus H

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. AIMS:To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral ca...

journal_title：Experimental and molecular pathology

authors： de Faria PR,Chammas R,de Melo TL,Hsu DK,Liu FT,Nonogaki S,Cardoso SV,Loyola AM

更新日期：2011-04-01 00:00:00

abstract：:Previous experiments showed that the presence of high levels of acute phase reactants (APR) enhance CCl4-induced liver fibrosis in the rat. A high correlation was found between the degree of fibrosis and alpha 2-macroglobulin of the rat (alpha 2-macrofetoprotein, alpha M-FP) used for monitoring the acute phase respons...

journal_title：Experimental and molecular pathology

authors： van Gool J,de Nie I,Smit J,Zuyderhoudt FM

更新日期：1986-10-01 00:00:00

abstract：:The relative resistance of fibroblasts to hypoxia and their remarkable adaptive plasticity in response to rapid changes in local tissue microenvironment made interstitial cardiac fibroblasts to be a key player in post-myocardial infarction myocardial repair. Cardiac fibroblasts are abundantly presented in the intersti...

journal_title：Experimental and molecular pathology

authors： Chistiakov DA,Orekhov AN,Bobryshev YV

更新日期：2016-10-01 00:00:00

abstract：:Host immune status is an important determinant of disease progression. Infections in the genital tract may alter the immunity in the particular site and hence affect the production of local cytokines. We performed this study to determine whether HIV in association with cervical HPV and CT/GC infections influences the ...

journal_title：Experimental and molecular pathology

authors： Guha D,Chatterjee R

更新日期：2009-02-01 00:00:00

abstract：OBJECT:Mutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing ...

journal_title：Experimental and molecular pathology

authors： Jha P,Suri V,Sharma V,Singh G,Sharma MC,Pathak P,Chosdol K,Jha P,Suri A,Mahapatra AK,Kale SS,Sarkar C

更新日期：2011-08-01 00:00:00

abstract：:Ten cases of myopathy caused by glycogen storage diseases of type II, III, and V, and phosphorylase b kinase deficiency are reported. So-called "abnormal lysosomes" or glycogenosomes which contain abundant glycogen were found in cases of type II, and in some numbers, in cases of type III, and in one case of phosphoryl...

journal_title：Experimental and molecular pathology

authors： Iwamasa T,Fukuda S,Tokumitsu S,Ninomiya N,Matsuda I,Osame M

更新日期：1983-06-01 00:00:00