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Pulmonary toxicity of cyclophosphamide: a 1-year study.

Abstract：

:The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and, 1 year later, occupied large areas in all lung lobes. There was also diffuse interstitial fibrosis. Chemical determination done 3, 12, 24, and 52 weeks after cyclophosphamide showed that lungs of animals treated with cyclophosphamide had significantly more hydroxyproline per lung than controls. One year after cyclophosphamide pressure-volume curves measured in vivo were shifted down and to the right and total lung volumes were decreased. A single injection of cyclophosphamide produced an irreversible and progressive pulmonary lesion.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

doi

10.1016/0014-4800(85)90031-0

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

251-60

issue

2

eissn

0014-4800

issn

1096-0945

pii

0014-4800(85)90031-0

journal_volume

42

pub_type

杂志文章

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