Abstract：
BACKGROUND:Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. AIMS:To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral carcinogenesis. METHODS:Galectin-3-deficient (gal3(-/-)) and wild-type (gal3(+/+)) mice were challenged with 4-nitroquinoline-1-oxide in drinking water for 16weeks and killed at different times. Tongues were removed and the number of dysplasias and carcinomas was counted. An immunohistochemical study for galectin-3 was performed only in the tongue from gal3(+/+) mice. RESULTS:In both groups, a reduction of dysplasias and an increase of carcinomas from week 16 to week 32 (p>0.05) were observed. A predominance of high cytoplasmic and nuclear galectin-3 expression was observed in carcinomas (64.7%) and dysplasias (55.5%), respectively (p>0.05). The perilesional areas always presented a statistical cytoplasmic and nuclear galectin-3 overexpression. CONCLUSIONS:Absence of galectin-3 did not directly affect the process of carcinogenesis and a cytoplasm shift of galectin-3 seems to be associated with development of tongue carcinomas.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
de Faria PR,Chammas R,de Melo TL,Hsu DK,Liu FT,Nonogaki S,Cardoso SV,Loyola AMdoi
10.1016/j.yexmp.2010.12.007subject
Has Abstractpub_date
2011-04-01 00:00:00pages
189-93issue
2eissn
0014-4800issn
1096-0945pii
S0014-4800(10)00179-6journal_volume
90pub_type
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