当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Three discrete areas within the chromosomal 8p21.3-23 region are associated with the development of breast carcinoma of Indian patients.

Three discrete areas within the chromosomal 8p21.3-23 region are associated with the development of breast carcinoma of Indian patients.

Abstract：

:Deletion in the 22.9 -Mb chromosomal (chr.) 8p21.3-23 region has been shown to be necessary for the development of breast carcinoma (CaBr). In this study, we have attempted to detect the minimal deleted region(s) in the chr.8p21.3-23 region in 62 primary breast lesions having 56 CaBr tumors and six other breast lesions of Indian patients using 15 microsatellite markers. The loss of heterozygosity (LOH) was observed for at least one marker in 96.4% (54/56) of the CaBr samples. Three discrete minimal deleted regions with high frequencies of LOH (39-65%) were identified in the chromosomal 8p23.1-23.2 (D1), 8p23.1 (D2) and 8p 21.3-22 (D3) regions within 2.03, 0.41, 2.47 Mb, respectively. No significant correlation was observed with the high deleted regions and the different clinicopathological parameters. Interestingly, 51.8% (29/56) CaBr samples showed either loss of chr.8p or interstitial deletions in this arm, indicating the importance of chr.8p in the development of CaBr. The pattern of allelic loss in the bilateral lesions had indicated that the lesions were clonal in origin and probably the deletion in the D3 region was the early event among the D1-D3 regions. Thus, our data have indicated that the D1-D3 regions could harbor candidate tumor suppressor gene(s) (TSGs) associated with the development of CaBr.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Bhattacharya N,Chunder N,Basu D,Roy A,Mandal S,Majumder J,Roychowdhury S,Panda CK

doi

10.1016/j.yexmp.2004.01.002

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

264-71

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014480004000048

journal_volume

76

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP.

    abstract：:Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma (DLBCL) p...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.yexmp.2015.08.019

    authors： Wong KK,Ch'ng ES,Loo SK,Husin A,Muruzabal MA,Møller MB,Pedersen LM,Pomposo MP,Gaafar A,Banham AH,Green TM,Lawrie CH

    更新日期：2015-12-01 00:00:00

  • TNF signaling in vascular endothelial cells.

    abstract：:Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1006/exmp.2001.2368

    authors： Madge LA,Pober JS

    更新日期：2001-06-01 00:00:00

  • Liver necrosis induced by thyroid hormone administration in rats fed ethanol.

    abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2381

    authors： Li J,French BA,Fu P,French SW

    更新日期：2001-08-01 00:00:00

  • Histone gene (H3) expression in chemically transformed oral keratinocytes.

    abstract：:The hamster cheek pouch is an excellent target tissue for the experimental study of oral carcinogenesis. In the course of searching for molecular alterations during the malignant transformation process, the necessity for a molecular marker for cellular proliferation became apparent. In this report, we show that the ce...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90034-2

    authors： Wong DT

    更新日期：1988-10-01 00:00:00

  • MiR-410 exerts neuroprotective effects in a cellular model of Parkinson's disease induced by 6-hydroxydopamine via inhibiting the PTEN/AKT/mTOR signaling pathway.

    abstract：:Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.05.002

    authors： Ge H,Yan Z,Zhu H,Zhao H

    更新日期：2019-08-01 00:00:00

  • Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2.

    abstract：:Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.04.003

    authors： Chen X,Shi C,Meng X,Zhang K,Li X,Wang C,Xiang Z,Hu K,Han X

    更新日期：2016-08-01 00:00:00

  • Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.

    abstract：:Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)1 and 2 signaling is a potent activator of tumor angiogenesis. Although the expressions of VEGFR1 and VEGFR2 were initially thought to be limited to the endothelial cells, it is now known that both the receptors are expressed in tumor cells. This is the fi...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104408

    authors： Tamura R,Sato M,Morimoto Y,Ohara K,Kosugi K,Oishi Y,Kuranari Y,Murase M,Yoshida K,Toda M

    更新日期：2020-06-01 00:00:00

  • Abnormal accumulation of elastin-associated microfibrils during elastolysis in the arterial wall.

    abstract：:We examined the correlation between elastolysis and abnormal accumulation of microfibrils in the arteries of rabbits using light and electron microscopic and tissue culture techniques. Partial constriction of the common carotid arteries of rabbits gave rise to gradual atrophy of the media with elastolysis and an unusu...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(90)90054-h

    authors： Katsuda S,Okada Y,Nakanishi I

    更新日期：1990-02-01 00:00:00

  • Effect of chronic treatment with cystic fibrosis fibroblast medium on rat submandibular gland acinar cells.

    abstract：:The effect of chronic treatment with cystic fibrosis (CF) fibroblast medium on rat submandibular gland and pancreas was investigated. Rats were injected for 8 days with conditioned medium from normal or CF fibroblasts. The elemental content of the acinar cells was measured by X-ray microanalysis of cryosections. A sig...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90064-4

    authors： von Euler AM,Ceder O,Kollberg H,Roomans GM

    更新日期：1985-08-01 00:00:00

  • Effect of oxytocin on lipid accumulation under inflammatory conditions in human macrophages.

    abstract：INTRODUCTION AND AIMS:Oxytocin (OT) is a neuropeptide hormone secreted by the posterior pituitary gland. Deficits in OT action have been observed in patients with behavioral and mood disorders, some of which correlate with an increased risk of cardiovascular disease (CVD). Recent research has revealed a wider systemic ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2021.104604

    authors： Karten A,Vernice NA,Renna HA,Carsons SE,DeLeon J,Pinkhasov A,Gomolin IH,Glass DS,Reiss AB,Kasselman LJ

    更新日期：2021-01-09 00:00:00

  • Effect of acute plasma fibronectin depletion on tissue fibronectin levels: analysis by a new fluorescent immunoassay.

    abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90010-8

    authors： Saba TM,Cho E,Blumenstock FA

    更新日期：1984-08-01 00:00:00

  • Angiocidin inhibits breast cancer proliferation through activation of epidermal growth factor receptor and nuclear factor kappa (NF-ĸB).

    abstract：:Angiocidin, a tumor-associated peptide, has been previously shown to inhibit tumor progression by blocking angiogenesis. We now show that angiocidin has a direct inhibitory effect on tumor cell proliferation. MDA-MB-231 breast cancer cells were inhibited from proliferating in the presence of epidermal growth factor (E...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.01.002

    authors： Godek J,Sargiannidou I,Patel S,Hurd L,Rothman VL,Tuszynski GP

    更新日期：2011-06-01 00:00:00

  • Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.

    abstract：:Angiogenesis is a common feature of pathological processes including wound healing, tumor formation, and chronic inflammation. Chronic inflammation can also be associated with dilation or proliferation of lymph vessels. We examined blood vessels and lymphatics and the expression of pro- and anti-angiogenic genes in th...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.05.015

    authors： HogenEsch H,Sola M,Stearns TM,Silva KA,Kennedy VE,Sundberg JP

    更新日期：2016-12-01 00:00:00

  • "Piecemeal" necrosis: renamed troxis necrosis.

    abstract：:Piecemeal necrosis, currently called interface hepatitis, is a feature of viral hepatitis as well as autoimmune hepatitis and steatohepatitis. The mechanism of liver cell loss and piecemeal necrosis needs to be determined. We hypothesize that piecemeal necrosis in hepatitis is due to a piecemeal removal of hepatocyte ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2397

    authors： Wang MX,Morgan T,Lungo W,Wang L,Sze GZ,French SW

    更新日期：2001-10-01 00:00:00

  • Acute sensitivity of BHT-induced alveolar toxicity to a diquat challenge in murine lungs.

    abstract：:In this study we investigated the effects of a mild toxic challenge at selected points in time on the nonspecific cellular events that occurred in acutely damaged pulmonary alveoli. Swiss-Webster mice were treated with butylated hydroxytoluene (BHT, 400 mg/kg ip) and sacrificed at Days 1, 3, and 5 thereafter; either 2...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(87)90078-5

    authors： Coulombe PA,Lassonde G,Côté MG

    更新日期：1987-10-01 00:00:00

  • WITHDRAWN: Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosis.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.05.003

    authors： Wu N,Zhang X,Jia P,Jia D

    更新日期：2015-05-07 00:00:00

  • Autologous bone marrow mesenchymal cell transplantation improves left ventricular function in a rabbit model of dilated cardiomyopathy.

    abstract：BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) could differentiate into cardiomyocytes. In this study, we wished to determine whether we could improve ventricular function in a dilated cardiomyopathy (DCM) model in the rabbit by injecting stem cells directly into the ventricular wall. METHODS AND RESULTS:Japane...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.12.002

    authors： Chen Y,Liu W,Li W,Gao C

    更新日期：2010-04-01 00:00:00

  • Fusion of storage lysosomes in experimental lipidosis and glycogenosis.

    abstract：:This ultrastructural investigation on renal collecting duct cells and hepatocytes of rats deals with the question of whether or not lipid-storage lysosomes as induced by cationic amphiphilic compounds retain their ability to fuse with autophagosomes/autolysosomes. These were recognized by their glycogen content which ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(87)90037-2

    authors： Lüllmann-Rauch R,Watermann D

    更新日期：1987-02-01 00:00:00

  • Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper.

    abstract：:The pathogenesis of skeletal muscle necrosis induced by crude Bothrops asper venom and isolated myotoxic phospholipase was studied using light and electron microscopy. White mice were injected intramuscularly with a dose of 2.5 micrograms/g and tissue samples were taken at 30 min and 1, 3, 6, 12, 24, and 48 hr. Toxin-...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90054-6

    authors： Gutiérrez JM,Ownby CL,Odell GV

    更新日期：1984-06-01 00:00:00

  • LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma.

    abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104333

    authors： Li H,Piao L,Xu D,Xuan Y

    更新日期：2020-02-01 00:00:00

  • Hepatoprotective effects of prostacyclins on CCl4-induced liver injury in rats.

    abstract：:Certain biochemical parameters of acute liver injury induced by carbon tetrachloride were investigated in rats treated with prostacyclin (PGI2) and two of its derivatives. Serum glutamate oxalacetate transaminase elevation and both triglyceride accumulation and reduction of glycogen content in liver were significantly...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90024-3

    authors： Divald A,Ujhelyi E,Jeney A,Lapis K,Institoris L

    更新日期：1985-04-01 00:00:00

  • Increased density of macrophage migration inhibitory factor (MIF) in tuberculosis granuloma.

    abstract：:Granulomas, the pathologic hallmarks of tuberculosis, are composed of tightly numerous immune cells that respond to a variety of persistent stimuli during pathogen-host interaction. The granuloma is essential for host containment of mycobacterial infection, however, the mechanism of host and pathogen determinants to r...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.05.004

    authors： Wang D,Zhou W,Lu S,Wang Q,Feng Y,Zhu G,Li L,Song Y,Gao Q

    更新日期：2012-10-01 00:00:00

  • Poly (ADP) ribose synthetase inhibition in alveolar macrophages undergoing hypoxia and reoxygenation.

    abstract：BACKGROUND:Inhibition of the nuclear enzyme poly ribose synthetase (PARS) protects against in vivo lung ischemia reperfusion injury (LIRI). The effectiveness of intratracheal treatment suggests that PARS inhibition may primarily modulate alveolar macrophage (AM) activation. These studies attempted to characterize the e...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.11.005

    authors： McCourtie AS,Farivar AS,Woolley SM,Merry HE,Wolf PS,Szabo C,Mulligan MS

    更新日期：2008-04-01 00:00:00

  • High flow drives vascular endothelial cell proliferation during flow-induced arterial remodeling associated with the expression of vascular endothelial growth factor.

    abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00032-7

    authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

    更新日期：2003-08-01 00:00:00

  • Effects of cis-diamminedichloroplatinum II (cisplatin) on the splenic tissue of rats: a histoquantitative study.

    abstract：:Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent d...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1027

    authors： Milićević Z,Slepcević V,Nikolić D,Zivanović V,Milićević NM

    更新日期：1994-10-01 00:00:00

  • Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma.

    abstract：:CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1037

    authors： Figge J,del Rosario AD,Gerasimov G,Dedov I,Bronstein M,Troshina K,Alexandrova G,Kallakury BV,Bui HX,Bratslavsky G

    更新日期：1994-12-01 00:00:00

  • Cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions: report of 2 cases.

    abstract：:We previously hypothesized that cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions. In this context we evaluated additional cases to further confirm that hypothesis. We report on 2 additional cases in which clonal cytogenetic abnormalities were observed in otherwise morpho...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.10.003

    authors： Symons WA,Flynt FL,Mendiola C,Ortega V,Higgins RA,Velagaleti GV

    更新日期：2013-02-01 00:00:00

  • Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices.

    abstract：:The keratinocyte growth factor (KGF) regulates cell growth and behavior in an autocrine or paracrine manner. In colorectal cancer tissues, KGF is expressed in tumor cells and adjacent stromal fibroblasts. We have constructed a KGF-gene-transfected cell line (HCT15-KGF) from a colorectal cancer cell line, HCT-15, that ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.07.001

    authors： Kudo M,Ishiwata T,Nakazawa N,Kawahara K,Fujii T,Teduka K,Naito Z

    更新日期：2007-12-01 00:00:00

  • Macrophage degradation of LDL extracted from human aortic plaques: effect of isolation conditions.

    abstract：:Several laboratories have recently reported on the structural and functional characteristics of an LDL fraction isolated from atherosclerotic lesions, designated A-LDL. Given the wide variety of tissue sources and isolation conditions that have been employed, we have addressed whether several procedures currently used...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(91)90045-y

    authors： Hoff HF,O'Neil J,Cole TB

    更新日期：1991-02-01 00:00:00

  • Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequences.

    abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.02.002

    authors： Bastian FO,Dash S,Garry RF

    更新日期：2004-08-01 00:00:00