LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma.

abstract：:Lymph node involvement of chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is characterised by the diffuse infiltration of small neoplastic lymphocytes, which is accompanied by the presence of proliferation centres (PCs) comprising prolymphocytes and paraimmunoblasts. There is increasing evidence of ...

journal_title：Experimental and molecular pathology

authors： Szurián K,Csala I,Marosvári D,Rajnai H,Dezső K,Bödör C,Piurkó V,Matolcsy A,Reiniger L

更新日期：2018-10-01 00:00:00

abstract：:Attempts to establish a tissue bank from autopsy samples have led to uncovering of the secrets of many diseases. Here, we examined the length of time that the RNA from postmortem tissues is available for microarray analysis and reported the gene expression profile for up- and down-regulated genes during the postmortem...

journal_title：Experimental and molecular pathology

authors： Sobue S,Sakata K,Sekijima Y,Qiao S,Murate T,Ichihara M

更新日期：2016-06-01 00:00:00

abstract：:A dramatic increase in the plasma glucagon/insulin ratio can be induced by treating fasted rats with antilipolytic drugs (e.g., with 3,5-dimethylpyrazole, 12 mg/kg body wt). These hormone changes are the physiologically appropriate response to a rapid decrease in free fatty acids and glucose plasma levels. Under this ...

journal_title：Experimental and molecular pathology

authors： Bergamini E,De Tata V,Cubeddu TL,Masiello P,Pollera M

更新日期：1987-02-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung...

journal_title：Experimental and molecular pathology

authors： Chen X,Shi C,Meng X,Zhang K,Li X,Wang C,Xiang Z,Hu K,Han X

更新日期：2016-08-01 00:00:00

abstract：:To study the effects of homocysteine on epithelial and stromal tissues, the free base of homocysteine thiolactone was synthesized and administered to mice. Intraperitoneal and intramuscular doses of 0.2 to 2.0 mg/g are acutely toxic, causing as much as 90% mortality because of intense tissue necrosis at the injection ...

journal_title：Experimental and molecular pathology

authors： McCully KS,Vezeridis MP

更新日期：1989-10-01 00:00:00

abstract：:Changes in lung structure and collagen metabolism were studied at 1, 2, 3, 4, 6, and 8 weeks in a model of pulmonary fibrosis induced in rats with paraquat plus hyperoxia. Morphologic examination of the lungs revealed that the earliest lesions consisted of severe and irreversible endothelial and alveolar epithelial ce...

journal_title：Experimental and molecular pathology

authors： Selman M,Montaño M,Ramos C,Barrios R,Pérez-Tamayo R

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

journal_title：Experimental and molecular pathology

authors： Tian RH,Guo KM,Han GH,Bai Y

更新日期：2020-08-01 00:00:00

abstract：:In the present study, BALB/c mice were used to develop a model for the hepatic injury associated to dengue infection. Histological analysis after subcutaneous inoculation with a low viral dose of dengue-2 virus showed Kupffer cell hyperplasia and an increased inflammatory cellular infiltrate next to the bile ducts on ...

journal_title：Experimental and molecular pathology

authors： França RF,Zucoloto S,da Fonseca BA

更新日期：2010-12-01 00:00:00

abstract：:As the number of elderly patients increases, some patients with heart problems may also need surgery. The purpose of this study was to investigate whether dexmedetomidine (DEX), a common used anesthetic, was beneficial to the patients with heart problems. Myocardial cells induced by doxorubicin (DOX) was to simulate t...

journal_title：Experimental and molecular pathology

authors： He Y,Yang Z,Li J,Li E

更新日期：2020-04-01 00:00:00

abstract：:Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of...

journal_title：Experimental and molecular pathology

authors： Bonita RE,Rose NR,Rasooly L,Caturegli P,Burek CL

更新日期：2002-12-01 00:00:00

abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

journal_title：Experimental and molecular pathology

authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

更新日期：1997-01-01 00:00:00

abstract：:We have previously reported the mechanism behind the myocardial injury and the activation of autonomic nervous system during the ischemia-reperfusion (IR) of the rat brain. This study was planned to investigate the effect of carvedilol, a β-blocker, in improving the myocardial injury caused by IR of the rat brain. We ...

journal_title：Experimental and molecular pathology

authors： Harima M,Arumugam S,Wen J,Pitchaimani V,Karuppagounder V,Afrin MR,Sreedhar R,Miyashita S,Nomoto M,Ueno K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:Previous experiments showed that the presence of high levels of acute phase reactants (APR) enhance CCl4-induced liver fibrosis in the rat. A high correlation was found between the degree of fibrosis and alpha 2-macroglobulin of the rat (alpha 2-macrofetoprotein, alpha M-FP) used for monitoring the acute phase respons...

journal_title：Experimental and molecular pathology

authors： van Gool J,de Nie I,Smit J,Zuyderhoudt FM

更新日期：1986-10-01 00:00:00

abstract：:The extracellular localizations of urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) were examined in cultured bovine capillary endothelial cells (BCEs) by an immunofluorescence method using BCEs treated with or without saponin and focal ...

journal_title：Experimental and molecular pathology

authors： Murata T,Nakashima Y,Yasunaga C,Maeda K,Sueishi K

更新日期：1991-10-01 00:00:00

abstract：:Protection of intestinal graft mucosa during cold preservation is still an unmet need in clinical practice, thus affecting the success of transplantation. The present study investigates the ability of two ischemic preconditioning (IPC) procedures to limit cold preservation injury. Three groups of Sprague-Dawley rats w...

journal_title：Experimental and molecular pathology

authors： Jonecova Z,Toth S,Maretta M,Ciccocioppo R,Varga J,Rodrigo L,Kruzliak P

更新日期：2015-10-01 00:00:00

abstract：:Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpres...

journal_title：Experimental and molecular pathology

authors： Sirica AE,Almenara JA,Li C

更新日期：2014-12-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer-related deaths in both men and women, and effective preventatives are rare due to the difficulty of early detection. Specific gene expression signatures have been identified in individuals that already developed lung cancer. To identify if gene expression differences coul...

journal_title：Experimental and molecular pathology

authors： Stearns TM,Cario CL,Savage HS,Sundberg JP,Paigen B,Berndt A

更新日期：2012-12-01 00:00:00

abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...

journal_title：Experimental and molecular pathology

authors： McNulty SN,Schwetye K,Goldstein M,Carter J,Schmidt RE,Ansstas G,Tsien CI,Kim AH,Dahiya S

更新日期：2018-12-01 00:00:00

abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

journal_title：Experimental and molecular pathology

authors： Saba TM,Cho E,Blumenstock FA

更新日期：1984-08-01 00:00:00

abstract：:We have investigated the incidence of the C677T and A1298C methylene tetrahydrofolate reductase (MTHFR) gene single nucleotide polymorphisms (SNPs) in the South Indian Tamil Nadu population with a total number of 72 individuals. The MTHFR genotyping was performed using the polymerase chain reaction followed by restric...

journal_title：Experimental and molecular pathology

authors： Angeline T,Jeyaraj N,Granito S,Tsongalis GJ

更新日期：2004-10-01 00:00:00

abstract：:We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oi...

journal_title：Experimental and molecular pathology

authors： Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

更新日期：1995-02-01 00:00:00

abstract：:Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

journal_title：Experimental and molecular pathology

authors： Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

更新日期：2013-08-01 00:00:00

abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

journal_title：Experimental and molecular pathology

authors： Haywood S,Loughran M,Batt RM

更新日期：1985-10-01 00:00:00

abstract：:Interactions of the basic multivalent ligand cationized ferritin (CF) with cultured cells markedly alter their endocytic function. In this study, the influence of CF treatment on the binding, internalization, and degradation of chemically modified (acetylated) low-density lipoproteins (Ac-LDL) was examined in aortic s...

journal_title：Experimental and molecular pathology

authors： Sprague EA,Edwards EH,Valente AJ,Suenram CA,Kerbacher JJ,Schwartz CJ

更新日期：1988-06-01 00:00:00

abstract：:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contain...

journal_title：Experimental and molecular pathology

authors： Müller RM,Roomans GM

更新日期：1984-12-01 00:00:00

abstract：:Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

journal_title：Experimental and molecular pathology

authors： Winocour PD,Hryhorenko L

更新日期：1995-12-01 00:00:00

abstract：:The morphology of Gleason 4 prostate cancer (PCa) can be subdivided into cribriform and non-cribriform patterns. A large body of evidence has shown that pattern 4 cribriform PCa (especially non-glomeruloid type) is associated with adverse pathologic features and clinical outcomes compared with non-cribriform pattern 4...

journal_title：Experimental and molecular pathology

authors： Xiao GQ,Nguyen E,Unger PD,Sherrod AE

更新日期：2020-06-01 00:00:00

abstract：:Genes involved in the control of cell proliferation and survival (those genes most important to cancer pathogenesis) are often specifically regulated at the translational level, through RNA-protein interactions involving the 5'-untranslated region of the mRNA. IGF1R is a proto-oncogene strongly implicated in human bre...

journal_title：Experimental and molecular pathology

authors： Blume SW,Jackson NL,Frost AR,Grizzle WE,Shcherbakov OD,Choi H,Meng Z

更新日期：2010-06-01 00:00:00

abstract：:Paraoxonase gene polymorphisms (PON1-55 and PON1-192) were determined in four Mexican populations (Mestizos, Nahuas, Teenek and Mayos) belonging to different ethnic groups. The role of these polymorphisms in the lipid profile in the Mestizo group was also analyzed. PON1 polymorphisms were determined by polymerase chai...

journal_title：Experimental and molecular pathology

authors： Gamboa R,Zamora J,Rodríguez-Pérez JM,Fragoso JM,Cardoso G,Posadas-Romero C,Vargas-Alarcón G

更新日期：2006-02-01 00:00:00