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Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.

Abstract：

:Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpressed and hypersecreted in large part, if not exclusively, by cancer-associated fibroblasts within the tumor stroma. Through its interaction with specific components of the extracellular tumor matrix, particularly collagen type I and tenascin-C, and with cell surface receptors, notably integrins leading to activation of the Akt and FAK signaling pathways, this TGF-β family-inducible matricellular protein appears to be functioning as a key extracellular matrix molecule regulating such critically important and diverse malignant tumor behaviors as tumor fibrogenesis and desmoplasia, invasive malignant cell growth, chemoresistance, and metastatic colonization. This review will discuss current evidence and basic molecular mechanisms implicating periostin as a mediator of intrahepatic cholangiocarcinoma invasive growth. In addition, its significance as a potential prognostic biomarker for intrahepatic cholangiocarcinoma patients, as well as future possibilities and challenges as a molecular target for cholangiocarcinoma therapy and/or prevention, will be critically evaluated.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Sirica AE,Almenara JA,Li C

doi

10.1016/j.yexmp.2014.10.007

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

515-24

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(14)00167-1

journal_volume

97

pub_type

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