The effect of mild hyperthermia on the morphology and function of murine resident peritoneal macrophages.


:During short term culture of murine resident peritoneal macrophages, increasing the temperature from 37 to 39 degrees C resulted in an increased activity of several surface receptors (FcR and receptor for gluteraldehyde-fixed sheep red blood cells), enhanced phagocytosis of yeast particles, improved spreading, and an accelerated reduction of nitroblue tetrazolium. At 41 degrees C, however, significant reduction of several functional properties (endocytosis of colloidal gold and horseradish peroxidase, phagocytosis of yeast particles) and a decrease in the reduction of nitroblue tetrazolium, the incorporation of tritiated uridine, and Fc and C3b surface receptor activity were observed. In addition morphological evidence of apoptosis, observed in a small number of cells cultured at 39 degrees C and in the majority of macrophages maintained at 41 degrees C, was confirmed by DNA electrophoresis. The data indicates that a reduction of several functional activities of macrophages occurs at 41 degrees C and apoptosis may largely account for these effects.


Exp Mol Pathol


van Bruggen I,Robertson TA,Papadimitriou JM





Has Abstract


1991-10-01 00:00:00














  • Spectrin oligomerization is cooperatively coupled to membrane assembly: a linkage targeted by many hereditary hemolytic anemias?

    abstract::In the erythrocyte, ankyrin is the major adapter protein linking tetramers of band 3 to the spectrin-actin cytoskeleton. This linkage involves a direct interaction between ankyrin and the 14th-15th repeat unit of beta-spectrin. The spectrin cytoskeleton itself is stabilized by the self-association of spectrin heterodi...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Giorgi M,Cianci CD,Gallagher PG,Morrow JS

    更新日期:2001-06-01 00:00:00

  • Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF alpha messenger RNA.

    abstract::We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oi...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

    更新日期:1995-02-01 00:00:00

  • Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis.

    abstract::Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been shown to ameliorate the clinical signs of EAE by suppressing the productio...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Liu N,Kan QC,Zhang XJ,Xv YM,Zhang S,Zhang GX,Zhu L

    更新日期:2014-12-01 00:00:00

  • Molecular evaluation of BRAF gene mutation in thyroid tumors: Significant association with papillary tumors and extra thyroidal extension indicating its role as a biomarker of aggressive disease.

    abstract:BACKGROUND:Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid. METH...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Ahmad F,Nathani R,Venkat J,Bharda A,Vanere V,Bhatia S,Das BR

    更新日期:2018-12-01 00:00:00

  • Functional and morphological differences between human alveolar and interstitial macrophages.

    abstract::Macrophages play an essential role in pulmonary host defense. They are, however, a heterogeneous cell population located in different lung compartments. This study was designed to elucidate differences between two macrophage populations obtained from the human lung, i.e., alveolar macrophages (AM) and interstitial mac...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Fathi M,Johansson A,Lundborg M,Orre L,Sköld CM,Camner P

    更新日期:2001-04-01 00:00:00

  • Tubular cell senescence and expression of TGF-beta1 and p21(WAF1/CIP1) in tubulointerstitial fibrosis of aging rats.

    abstract::Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

    更新日期:2001-02-01 00:00:00

  • The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).

    abstract::As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibro...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Jia Y,Ji P,French B,Tillman B,French SW

    更新日期:2019-06-01 00:00:00

  • Cytoskeleton-dependent surface blebbing induced by the polar solvent N-methylformamide.

    abstract::In vivo and in vitro studies performed on the polar solvent N-methylformamide (NMF), as well as on its association with chemotherapeutic agents or X rays, have clearly demonstrated that this compound is capable of inducing changes in biological characteristics of tumor cells, e.g., cell differentiation. However, the m...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Malorni W,Meschini S,Arancia G

    更新日期:1992-10-01 00:00:00

  • Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas.

    abstract::Lung cancer is the most common cause of cancer-related deaths in both men and women, and effective preventatives are rare due to the difficulty of early detection. Specific gene expression signatures have been identified in individuals that already developed lung cancer. To identify if gene expression differences coul...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Stearns TM,Cario CL,Savage HS,Sundberg JP,Paigen B,Berndt A

    更新日期:2012-12-01 00:00:00

  • Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms.

    abstract::Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

    更新日期:2013-08-01 00:00:00

  • Three discrete areas within the chromosomal 8p21.3-23 region are associated with the development of breast carcinoma of Indian patients.

    abstract::Deletion in the 22.9 -Mb chromosomal (chr.) 8p21.3-23 region has been shown to be necessary for the development of breast carcinoma (CaBr). In this study, we have attempted to detect the minimal deleted region(s) in the chr.8p21.3-23 region in 62 primary breast lesions having 56 CaBr tumors and six other breast lesion...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Bhattacharya N,Chunder N,Basu D,Roy A,Mandal S,Majumder J,Roychowdhury S,Panda CK

    更新日期:2004-06-01 00:00:00

  • Glycosaminoglycans of normal and hypertrophic human scar.

    abstract::The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Donoff RB,Swann DA,Schweidt SH

    更新日期:1984-02-01 00:00:00

  • Adhesion molecules as susceptibility factors in spontaneous autoimmune thyroiditis in the NOD-H2h4 mouse.

    abstract::Mononuclear cell infiltration of the thyroid is a prominent feature of chronic lymphocytic thyroiditis. Adhesion molecules play a major role in determining the localization of inflammatory mononuclear cells in the thyroid. Previous reports from animal models and human studies have described the thyroidal expression of...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Bonita RE,Rose NR,Rasooly L,Caturegli P,Burek CL

    更新日期:2002-12-01 00:00:00

  • Effect of chronic treatment with cystic fibrosis fibroblast medium on rat submandibular gland acinar cells.

    abstract::The effect of chronic treatment with cystic fibrosis (CF) fibroblast medium on rat submandibular gland and pancreas was investigated. Rats were injected for 8 days with conditioned medium from normal or CF fibroblasts. The elemental content of the acinar cells was measured by X-ray microanalysis of cryosections. A sig...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: von Euler AM,Ceder O,Kollberg H,Roomans GM

    更新日期:1985-08-01 00:00:00

  • Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis.

    abstract::Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin....

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami A

    更新日期:2003-06-01 00:00:00

  • Increased degradation in rat liver induced by antilipolytic agents: a model for studying autophagy and protein degradation in liver?

    abstract::A dramatic increase in the plasma glucagon/insulin ratio can be induced by treating fasted rats with antilipolytic drugs (e.g., with 3,5-dimethylpyrazole, 12 mg/kg body wt). These hormone changes are the physiologically appropriate response to a rapid decrease in free fatty acids and glucose plasma levels. Under this ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Bergamini E,De Tata V,Cubeddu TL,Masiello P,Pollera M

    更新日期:1987-02-01 00:00:00

  • Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine.

    abstract::Minoxidil, a vasodilating antihypertensive drug, was given orally at 10 mg/kg daily for 2 days to twelve 25- to 35-kg miniature pigs. Twelve control pigs were also studied. Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose. Gross examination showed diffuse hemorrhage in...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Van Vleet JF,Herman EH,Ferrans VJ

    更新日期:1984-08-01 00:00:00

  • Testicular damage by high doses of vitamin B6 (pyridoxine) in rats: a light and electron microscopical study.

    abstract::Male Wistar rats were administered daily intraperitoneal injections of 125, 250, 500, and 1000 mg/kg/day of vitamin B6 for 2 and 6 weeks and the histogenesis of the testicular damage was investigated. A reduction of germ cells was not prominent in the 2-week groups, whereas a delay in spermiation, degeneration of elon...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Kaido M,Mori K,Ide Y,Inoue N,Koide O

    更新日期:1991-08-01 00:00:00

  • Early effects of tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model.

    abstract::To understand the contribution of IL-6/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monk...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Kato A,Matsuo S,Takai H,Uchiyama Y,Mihara M,Suzuki M

    更新日期:2008-06-01 00:00:00

  • All-trans retinoic acid regulates the expression of apolipoprotein E in rats with glomerulosclerosis induced by Adriamycin.

    abstract::Apolipoprotein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a key role in the progression of glomerulosclerosis (GS). We conducted this investigation to explore whether all-trans retinoic acid (ATRA) could regulate the apoE expression in the pathological process of GS. 120 Wistar rats w...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

    更新日期:2011-06-01 00:00:00

  • Isolation and characterization of crinosomes--a subclass of secondary lysosomes.

    abstract::A technique is presented for isolating a subclass of lysosomes, designated crinosomes, by one-step floating-up centrifugation in a cesium-containing sucrose gradient. Rats were treated with vinblastine in order to induce the formation of crinosomes. Vinblastine blocked exocytosis of secretory granules at the cell bord...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Glaumann H,Ahlberg J,Hultenby K,Jansson H,Mengarelli-Widholm S,Motakefi AM

    更新日期:1989-04-01 00:00:00

  • Spontaneous diabetes in BB Wistar rats causes small increases in the early proliferative response of smooth muscle cells in re-injured aortae.

    abstract::Diabetic patients are at greater risk for restenosis following angioplasty, but the mechanisms involved remain unclear. Early proliferative changes in vessels following angioplasty contribute to the subsequent intimal thickening associated with restenosis. Materials released from platelets which interact with the inju...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Winocour PD,Hryhorenko L

    更新日期:1995-12-01 00:00:00

  • Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections.

    abstract::The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections were used to prepare tissue arrays to examine the intensity of fluorescence of IHC stained stem cell markers in liver tissue from malignant HCC tumors and accompa...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Buzzanco A,Gomez A,Rodriguez E,French BA,Tillman BA,Chang S,Ganapathy E,Junrungsee S,Zarrinpar A,Agopian VG,Naini BV,French SW Jr,French SW Sr

    更新日期:2014-12-01 00:00:00

  • Expression dynamics of drug resistance genes, multidrug resistance 1 (MDR1) and lung resistance protein (LRP) during the evolution of overt leukemia in myelodysplastic syndromes.

    abstract::It is well-known that leukemic cells of overt leukemia (OL) that have transformed from myelodysplastic syndromes (MDS) are more resistant to chemotherapy as compared with de novo AML cells. Thus, to examine the expression levels of drug-resistant genes and their alterations with the development of OL in MDS, the expre...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Kurata M,Hasegawa M,Nakagawa Y,Abe S,Yamamoto K,Suzuki K,Kitagawa M

    更新日期:2006-12-01 00:00:00

  • Periostin in intrahepatic cholangiocarcinoma: pathobiological insights and clinical implications.

    abstract::Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpres...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章,评审


    authors: Sirica AE,Almenara JA,Li C

    更新日期:2014-12-01 00:00:00

  • Central nervous system (CNS) tumor cell heterogeneity contributes to differential platinum-based response in an in vitro 2D and 3D cell culture approach.

    abstract::One of the models that best explains the cellular heterogeneity observed in central nervous system (CNS) tumors is the presence of cancer stem cells (CSCs). CSCs can originate from differentiated adult cells that return to an undifferentiated stage through the mechanism known as epithelial-mesenchymal transition (EMT)...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Gonçalves BÔP,Fialho SL,Silvestrini BR,Sena IFG,Dos Santos GSP,Assis Gomes D,Silva LM

    更新日期:2020-10-01 00:00:00

  • The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats.

    abstract:OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Chen P,Yan H,Chen Y,He Z

    更新日期:2009-04-01 00:00:00

  • Characterization of the anti-inflammation mechanism for the AO herbal extract.

    abstract::A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminate...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Ye H,Wang Y,Yan J,Jenson AB

    更新日期:2016-12-01 00:00:00

  • Spiroplasma spp. biofilm formation is instrumental for their role in the pathogenesis of plant, insect and animal diseases.

    abstract::Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Bastian FO,Elzer PH,Wu X

    更新日期:2012-08-01 00:00:00

  • Evaluation of formalin-free tissue fixation for RNA and microRNA studies.

    abstract::FineFix, RCL-2 and HOPE, three formalin-free fixatives, were compared to the common used formalin fixed tissue samples of lung cancer and were evaluated for their effects on quality, quantity and integrity of RNA and microRNA. Two commercially available RNA extraction Kits (RNeasy FFPE by Qiagen and RecoverAll™ Nuclei...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Arzt L,Kothmaier H,Quehenberger F,Halbwedl I,Wagner K,Maierhofer T,Popper HH

    更新日期:2011-10-01 00:00:00