Abstract:
:The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 ethnically matched healthy controls using the polymerase chain reaction-sequence specific oligonucleotides (PCR-SSO) technique. IDC patients showed increased frequencies of HLA-DR4 (pC=0.02, OR=1.87), HLA-DQB1*0301 (pC=0.02, OR=1.92) and HLA-DQB1*0302 (pC=0.02, OR=1.87) when compared to healthy controls. On the other hand, IDC patients also showed decreased frequencies of HLA-DR11 allele (pC=0.03, OR=0.26) and HLA-DQB1*0201 (pC=0.04, OR=0.41). These data suggest that variation in class II HLA alleles could be a genetic factor involved in the susceptibility to IDC of the Mexican Mestizo population.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Rodríguez-Pérez JM,Fragoso JM,Alvarez-León E,Martínez-Rodríguez N,Gallardo GJ,Inés-Real S,Granados J,Reyes PA,Vargas-Alarcón Gdoi
10.1016/j.yexmp.2006.10.002subject
Has Abstractpub_date
2007-02-01 00:00:00pages
49-52issue
1eissn
0014-4800issn
1096-0945pii
S0014-4800(06)00123-7journal_volume
82pub_type
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abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
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