Abstract：
:This ultrastructural investigation on renal collecting duct cells and hepatocytes of rats deals with the question of whether or not lipid-storage lysosomes as induced by cationic amphiphilic compounds retain their ability to fuse with autophagosomes/autolysosomes. These were recognized by their glycogen content which was made to persist by means of acarbose, an inhibitor of lysosomal alpha-glucosidase. To induce lipidosis, rats were pretreated for several weeks with chloroquine or chlorphentermine; they then received combined treatment with the lipidosis-inducing drug plus acarbose. In renal collecting duct cells, mixed storage lysosomes displaying the features of both lipidosis and glycogenosis were found to predominate, indicating that fusion between lipid-laden lysosomes and glycogen-containing autophagosomes/autolysosomes was efficient. Hepatocytes also displayed some mixed storage lysosomes; these were, however, regularly accompanied, within a given hepatocyte, by greater numbers of pure lipidosis-related inclusions and pure glycogen vacuoles. This observation indicates that in hepatocytes lipid-storage lysosomes were rather reluctant to fuse, thus displaying a feature of telolysosomes which are no longer capable of participating in cellular digestion.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Lüllmann-Rauch R,Watermann Ddoi
10.1016/0014-4800(87)90037-2subject
Has Abstractpub_date
1987-02-01 00:00:00pages
136-43issue
1eissn
0014-4800issn
1096-0945pii
0014-4800(87)90037-2journal_volume
46pub_type
杂志文章abstract：:While the EGFR and most of its ligands are expressed in the male reproductive tract, their functions in male reproduction are poorly understood. Interestingly, male transgenic mice overexpressing EGF are sterile, and transgenic mice overexpressing TGFA, another EGFR ligand, show an enlarged coagulation gland (anterior...
journal_title：Experimental and molecular pathology
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doi：10.1016/0014-4800(83)90059-x
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journal_title：Experimental and molecular pathology
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abstract：BACKGROUND:Somatic mutation of the BRAF gene is one to be the most commonly known genetic change in thyroid tumors especially papillary thyroid cancers. The T1799A activating point mutation is detected in >98% of the thyroid tumors, and result in substitution of amino acid valine at position 600 to glutamic acid. METH...
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章,评审
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更新日期：2003-08-01 00:00:00
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journal_title：Experimental and molecular pathology
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doi：10.1016/j.yexmp.2014.02.005
更新日期：2014-04-01 00:00:00
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pub_type： 杂志文章
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
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更新日期：1994-06-01 00:00:00
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更新日期：2017-04-01 00:00:00
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章,评审
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journal_title：Experimental and molecular pathology
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更新日期：1994-12-01 00:00:00
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journal_title：Experimental and molecular pathology
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更新日期：1993-02-01 00:00:00
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
doi：10.1016/0014-4800(92)90001-r
更新日期：1992-10-01 00:00:00
abstract：:Several studies recognize cancer-stromal fibroblasts' role in cancer-cell invasion and metastasis. Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion ...
journal_title：Experimental and molecular pathology
pub_type： 杂志文章
doi：10.1016/j.yexmp.2009.09.001
更新日期：2009-12-01 00:00:00
