Abstract:
:Ameloblastoma is a benign odontogenic neoplasm that may exhibit aggressive biological behavior as evidenced by its rapid growth and significance recurrence rates following initial surgical resection. Currently, the only therapy for ameloblastoma is surgical, and adjunctive treatment modalities are needed to mitigate tumor growth and to reduce the need for extensive and disfiguring surgeries. Many studies have identified markers expressed by ameloblastoma and these lend insight to our understanding of tumor progression. This review provides a summary of the specific molecular pathways implicated in tumor pathogenesis, including those involved in bone remodeling, apoptosis, cell signaling, and tumor suppression. Based on these data, we identify several prognostic or therapeutic markers that have been used successfully in the treatment of other neoplastic processes that may also have diagnostic and prognostic utility for ameloblastoma. Thus, it is important to determine which markers hold the greatest promise for clinical management of this benign neoplasm in order to improve treatment options, particularly in patients with aggressive forms of ameloblastoma.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Jhamb T,Kramer JMdoi
10.1016/j.yexmp.2014.09.001subject
Has Abstractpub_date
2014-12-01 00:00:00pages
345-53issue
3eissn
0014-4800issn
1096-0945pii
S0014-4800(14)00133-6journal_volume
97pub_type
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