In situ localization of tumor cells associated with the epithelial-mesenchymal transition marker Snail and the prognostic impact of lymphocytes in the tumor microenvironment in invasive ductal breast cancer.

abstract：:The dialysate fluid of uremic patients exhibits, in vitro, an inhibitory effect on cell growth, owing to urea, guanidino compounds, and substances named middle molecules. The polyamines are compounds which exhibit high levels in biological fluids during either normal development or disease such as psoriasis, uremia, a...

journal_title：Experimental and molecular pathology

authors： Stabellini G,Mariani G,Pezzetti F,Calastrini C

更新日期：1997-01-01 00:00:00

abstract：:The alterations, visible by light and electron microscopy, in the distal airway cells of Syrian golden hamsters were analyzed at several time intervals, from 6 hr to 4 weeks, after a single subcutaneous injection (120 mg/kg body wt) of 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen. 4NQO induced injurious effect...

journal_title：Experimental and molecular pathology

authors： Ito T

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to be critical in the onset and progression of acute myocardial ischemia (AMI). This study attempted to reveal the biological function of MALAT1 in AMI. METHODS:Expression of MALAT1 in H9c2 cells was silenced by shRNA-mediated...

journal_title：Experimental and molecular pathology

authors： Gong L,Chang H,Xu H

更新日期：2019-12-01 00:00:00

abstract：:In this comparative study, rat hearts were perfused at 37 degrees C with three clearly defined protocols: the Ca2+ paradox, the O(2) paradox, and with 20 mM caffeine. Each protocol involved an initial priming (Ca(2+)(0) depletion or anoxia; stage 1) and subsequent full activation (Ca(2+)(0) repletion, caffeine or reox...

journal_title：Experimental and molecular pathology

authors： Harding RJ,Duncan CJ

更新日期：1999-10-01 00:00:00

abstract：:We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we de...

journal_title：Experimental and molecular pathology

authors： Tegla CA,Cudrici CD,Nguyen V,Danoff J,Kruszewski AM,Boodhoo D,Mekala AP,Vlaicu SI,Chen C,Rus V,Badea TC,Rus H

更新日期：2015-06-01 00:00:00

abstract：:The effect of fish oil supplements on atherogenesis is controversial, especially when fish oil does not lower plasma cholesterol. Some studies in swine have shown that a fish oil supplement to a butter-cholesterol diet reduces atherogenesis. The fish oil supplement also frequently reduces average plasma cholesterol le...

journal_title：Experimental and molecular pathology

authors： Schmee J,Kim DN,Ross JS,Thomas WA

更新日期：1993-12-01 00:00:00

abstract：:Ureaplasma urealyticum is a common inhabitant of mucosal surfaces but is also associated with a higher incidence of pneumonia and bronchopulmonary dysplasia in preterm infants. Culture and polymerase chain reaction demonstrate high isolation rates of ureaplasma in clinical specimens documenting their presence but do n...

journal_title：Experimental and molecular pathology

authors： Benstein BD,Crouse DT,Shanklin DR,Ourth DD

更新日期：2003-10-01 00:00:00

abstract：:One week after intraperitoneal injection of rats and mice with a chemical irritant, the abdominal cavity was in the healing phase of a sterile peritonitis. At this time, mineral oil or a particulate dye or metal injected intraperitoneally was absorbed into lymph nodes in much larger amounts than normal. Absorption of ...

journal_title：Experimental and molecular pathology

authors： Levine S

更新日期：1985-08-01 00:00:00

abstract：:Thirty-nine patients with fibromyalgia syndrome (FMS) according to American College of Rheumatology criteria were studied for cell-mediated sensitivity to environmental chemicals. Lymphocytes were tested by standard [(3)H]thymidine incorporation in vitro for T cell memory to 11 chemical substances. Concanavalin A (Con...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Stevens MV,Hall MF,Smalley DL

更新日期：2000-10-01 00:00:00

abstract：:An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

journal_title：Experimental and molecular pathology

authors： Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

更新日期：1989-06-01 00:00:00

abstract：:Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Elzer PH,Wu X

更新日期：2012-08-01 00:00:00

abstract：:We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes and foam cells. Seventy Wistar rats were assigned to one of the following groups: (1) regular diet, (2) an atherogenic di...

journal_title：Experimental and molecular pathology

authors： Nunnari JJ,Fisher M,White SD

更新日期：1992-12-01 00:00:00

abstract：:A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

journal_title：Experimental and molecular pathology

authors： Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

更新日期：2014-12-01 00:00:00

abstract：:To investigate the role of N-acetylglucosaminyltransferases V (GnT-V) in the malignancy of human hepatocellular carcinoma (HCC), the GnT-V stably suppressed cell line HepG2 GnT-V/1564 was constructed from HepG2. The proliferation, migration, invasion, metastasis of HepG2 GnT-V/1564 was investigated both in vitro and i...

journal_title：Experimental and molecular pathology

authors： Wei T,Liu Q,He F,Zhu W,Hu L,Guo L,Zhang J

更新日期：2012-08-01 00:00:00

abstract：:Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpres...

journal_title：Experimental and molecular pathology

authors： Sirica AE,Almenara JA,Li C

更新日期：2014-12-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Experimental and molecular pathology

authors： Wu N,Zhang X,Jia P,Jia D

更新日期：2015-05-07 00:00:00

abstract：:We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oi...

journal_title：Experimental and molecular pathology

authors： Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

更新日期：1995-02-01 00:00:00

abstract：:The most common recurrent translocation in clear cell sarcoma t(12;22)(q13;q12) results in an EWSR1/ATF1 chimeric gene. We present a molecular analysis of tumor overgrowing right proximal tibia with bone destruction metastatic to two groin lymph nodes. Fluorescent in situ hybridization analysis performed on paraffin-e...

journal_title：Experimental and molecular pathology

authors： Jakubauskas A,Valceckiene V,Andrekute K,Seinin D,Kanopka A,Griskevicius L

更新日期：2011-04-01 00:00:00

abstract：:miR-126 has been implicated in the processes of inflammation and angiogenesis. Through these processes, miR-126 is implicated in cancer biology, but its role there has not been well reviewed. The aim of this review is to examine the molecular mechanisms and clinicopathological significance of miR-126 in human cancers....

journal_title：Experimental and molecular pathology

authors： Ebrahimi F,Gopalan V,Smith RA,Lam AK

更新日期：2014-02-01 00:00:00

abstract：:Formin-like 3 (FMNL3), a member of diaphanous-related formins subfamily, plays an important role in cytoskeleton reorganization, cell adhesion and cancer cell invasion in vitro. This study aimed to explore the expression of FMNL3 in colorectal carcinoma (CRC) cell-lines and tissues, and further evaluate its prognostic...

journal_title：Experimental and molecular pathology

authors： Zeng YF,Xiao YS,Lu MZ,Luo XJ,Hu GZ,Deng KY,Wu XM,Xin HB

更新日期：2015-04-01 00:00:00

abstract：:Using intact anesthetized rabbits and isolated perfused hearts, the hemodynamic and electrophysiological effects of mercury (Hg) were examined in order to assess the role of cardiovascular dysfunction in Hg intoxication. The most consistent and prominent cardiovascular effect was a significant reduction in blood press...

journal_title：Experimental and molecular pathology

authors： Rhee HM,Choi BH

更新日期：1989-06-01 00:00:00

abstract：:Ischemia has elicited a great deal of interest among the scientific community due to its role in life-threatening pathologies such as cancer, stroke, acute renal failure, and myocardial infarction. Oxygen deprivation (hypoxia) associated with ischemia has recently become a subject of intense scrutiny. New investigator...

journal_title：Experimental and molecular pathology

authors： Russ AL,Haberstroh KM,Rundell AE

更新日期：2007-10-01 00:00:00

abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

journal_title：Experimental and molecular pathology

authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

更新日期：2011-02-01 00:00:00

abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

journal_title：Experimental and molecular pathology

authors： Haywood S,Loughran M,Batt RM

更新日期：1985-10-01 00:00:00

abstract：:Fine-needle aspiration biopsy remains the mainstay for preoperative examination of thyroid nodules; however, it does not provide a definite diagnosis in up to 25% of nodules. Considerable studies have been performed to identify molecular markers to resolve this diagnostic dilemma. The aim of this study was to establis...

journal_title：Experimental and molecular pathology

authors： Liu S,Gao A,Zhang B,Zhang Z,Zhao Y,Chen P,Ji M,Hou P,Shi B

更新日期：2014-10-01 00:00:00

abstract：:One of the models that best explains the cellular heterogeneity observed in central nervous system (CNS) tumors is the presence of cancer stem cells (CSCs). CSCs can originate from differentiated adult cells that return to an undifferentiated stage through the mechanism known as epithelial-mesenchymal transition (EMT)...

journal_title：Experimental and molecular pathology

authors： Gonçalves BÔP,Fialho SL,Silvestrini BR,Sena IFG,Dos Santos GSP,Assis Gomes D,Silva LM

更新日期：2020-10-01 00:00:00

abstract：:A large surgical wound is required for implantation of silicone mammary devices. Formation of capsules around silicone devices follows wound healing processes except that the healing is conformed and significantly delayed by the physical presence of the implant. Multilayered capsules are thicker and lymphocytic and pl...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Smalley DL

更新日期：1999-09-01 00:00:00

abstract：:The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 eth...

journal_title：Experimental and molecular pathology

authors： Rodríguez-Pérez JM,Fragoso JM,Alvarez-León E,Martínez-Rodríguez N,Gallardo GJ,Inés-Real S,Granados J,Reyes PA,Vargas-Alarcón G

更新日期：2007-02-01 00:00:00

abstract：:Studies of spontaneous mutations in mice have provided valuable disease models and important insights into the mechanisms of human disease. Ruffled (rul) is a new autosomal recessive mutation causing abnormal hair coat in mice. The rul allele arose spontaneously in the RB156Bnr/EiJ inbred mouse strain. In addition to ...

journal_title：Experimental and molecular pathology

authors： Herbert Pratt C,Potter CS,Fairfield H,Reinholdt LG,Bergstrom DE,Harris BS,Greenstein I,Dadras SS,Liang BT,Schofield PN,Sundberg JP

更新日期：2015-04-01 00:00:00

abstract：:The CXC chemokine receptor CXCR4 was the first molecule identified as a coreceptor working in conjunction with CD4 to mediate cellular entry for the human immunodeficiency virus (HIV-1). Since that original discovery, 11 other seven-mtransmembrane domain molecules, many of which are chemokine receptors, have been show...

journal_title：Experimental and molecular pathology

authors： van der Meer P,Ulrich AM,Gonźalez-Scarano F,Lavi E

更新日期：2000-12-01 00:00:00