当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Hemodynamic and electrophysiological effects of mercury in intact anesthetized rabbits and in isolated perfused hearts.

Hemodynamic and electrophysiological effects of mercury in intact anesthetized rabbits and in isolated perfused hearts.

Abstract：

:Using intact anesthetized rabbits and isolated perfused hearts, the hemodynamic and electrophysiological effects of mercury (Hg) were examined in order to assess the role of cardiovascular dysfunction in Hg intoxication. The most consistent and prominent cardiovascular effect was a significant reduction in blood pressure. This cardiodepressive action was probably brought about by the primary action of Hg on the heart rather than by altered sympathetic activity, as evidenced by normal renal nerve activity at times when the hemodynamic actions of Hg were clearly manifest. Although the principal target organ for the toxic actions of inorganic Hg is the kidney, chronic exposure to both inorganic and organic Hg frequently results in signs and symptoms of CNS dysfunction. The profound hemodynamic effects of Hg that we have observed emphasize the potential importance of Hg cardiotoxicity and indicate the need to differentiate between the primary and the secondary effects of Hg intoxication on CNS tissues for evaluation of the toxic effects of Hg compounds.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Rhee HM,Choi BH

doi

10.1016/0014-4800(89)90038-5

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

281-90

issue

3

eissn

0014-4800

issn

1096-0945

pii

0014-4800(89)90038-5

journal_volume

50

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • A microscopic and ultrastructural evaluation of dibasic esters (DBE) toxicity in rat nasal explants.

    abstract：:Dibasic esters (DBE) solvent has been demonstrated to induce a mild degeneration of the olfactory, but not the respiratory epithelium of the rat nasal cavity following a 90-day inhalation exposure. Previous work has demonstrated that acid phosphatase release is a reliable index of DBE-induced cytotoxicity in an in vit...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(92)90037-c

    authors： Trela BA,Frame SR,Bogdanffy MS

    更新日期：1992-06-01 00:00:00

  • Cytokine levels in HIV infected and uninfected Indian women: correlation with other STAs.

    abstract：:Host immune status is an important determinant of disease progression. Infections in the genital tract may alter the immunity in the particular site and hence affect the production of local cytokines. We performed this study to determine whether HIV in association with cervical HPV and CT/GC infections influences the ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2008.10.001

    authors： Guha D,Chatterjee R

    更新日期：2009-02-01 00:00:00

  • Dynamic changes in conjunctival dendritic cell numbers, anatomical position and phenotype during experimental allergic conjunctivitis.

    abstract：:Dendritic cells (DCs) are a subset of antigen-presenting cells (APCs) that are involved in the initiation and control of the immune response to antigens present at the interface with the environment. A limited number of groups have studied DCs in human and animal conjunctiva but no data is available concerning the dif...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.04.007

    authors： Ohbayashi M,Manzouri B,Flynn T,Toda M,Ikeda Y,Nakamura T,Ono SJ

    更新日期：2007-10-01 00:00:00

  • Transient and ectopic expression of lumican by acinar cells in L-arginine-induced acute pancreatitis.

    abstract：:Lumican is a member of a small leucine-rich proteoglycan family. We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells. CP-like lesions are characterized by acinar and ductal-ductular cell p...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)80006-0

    authors： Naito Z,Ishiwata T,Lu YP,Teduka K,Fujii T,Kawahara K,Sugisaki Y

    更新日期：2003-02-01 00:00:00

  • Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis.

    abstract：:Angiogenesis is a common feature of pathological processes including wound healing, tumor formation, and chronic inflammation. Chronic inflammation can also be associated with dilation or proliferation of lymph vessels. We examined blood vessels and lymphatics and the expression of pro- and anti-angiogenic genes in th...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.05.015

    authors： HogenEsch H,Sola M,Stearns TM,Silva KA,Kennedy VE,Sundberg JP

    更新日期：2016-12-01 00:00:00

  • Dynamics of wound healing after silicone device implantation.

    abstract：:A large surgical wound is required for implantation of silicone mammary devices. Formation of capsules around silicone devices follows wound healing processes except that the healing is conformed and significantly delayed by the physical presence of the implant. Multilayered capsules are thicker and lymphocytic and pl...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1999.2269

    authors： Shanklin DR,Smalley DL

    更新日期：1999-09-01 00:00:00

  • Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma.

    abstract：:CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1037

    authors： Figge J,del Rosario AD,Gerasimov G,Dedov I,Bronstein M,Troshina K,Alexandrova G,Kallakury BV,Bui HX,Bratslavsky G

    更新日期：1994-12-01 00:00:00

  • Mosaicism in female hybrid hares heterozygous for glucose-6-phosphate dehydrogenase. VII. Evidence for selective advantage of one phenotype over the other in ditypic samples from aortas of hares fed cholesterol oxidation products.

    abstract：:In a previous study the authors demonstrated monotypic foci, all of timidus type, in the atherosclerotic lesions and normal aortic tissue of glucose-6-phosphate dehydrogenase (G-6-PD) mosaic hares fed 25-hydroxycholesterol or triol in addition to a high-cholesterol diet. Other hares fed the high-cholesterol diet witho...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90019-x

    authors： Lee KT,Janakidevi K,Kroms M,Schmee J,Thomas WA

    更新日期：1985-02-01 00:00:00

  • Expression of autocrine prolactin and the short isoform of prolactin receptor are associated with inflammatory response and apoptosis in monocytes stimulated with Mycobacterium bovis proteins.

    abstract：:Increased levels of prolactin (PRL) have recently been associated with carcinogenesis and the exacerbation of autoimmune diseases, and might be involved in the progression of tuberculosis (TB). To investigate the relationship between PRL and prolactin receptor (PRLr) expression with inflammatory response and apoptosis...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.03.016

    authors： López-Rincón G,Mancilla R,Pereira-Suárez AL,Martínez-Neri PA,Ochoa-Zarzosa A,Muñoz-Valle JF,Estrada-Chávez C

    更新日期：2015-06-01 00:00:00

  • Gene expression of tropoelastin is enhanced in the aorta proximal to the coarctation in rabbits.

    abstract：:To assess elastin biosynthesis in the aortic wall in response to acute elevation of blood pressure, we studied the aortic gene expression of tropoelastin in a rabbit midthoracic aortic coarctation model. The time points of the study were 1, 3, and 7 days and 2, 4, and 8 weeks after coarctation. Additional animals were...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2002.2423

    authors： Xu C,Zarins CK,Glagov S

    更新日期：2002-04-01 00:00:00

  • Microvessel density as a molecular marker for identifying high-grade prostatic intraepithelial neoplasia precursors to prostate cancer.

    abstract：BACKGROUND:Existing clinical data have shown that high-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor to prostate cancer (CaP). Criteria to distinguish HGPIN that progress to CaP from those that do not remain poorly defined. Our objective was to evaluate microvessel density as a molecula...

    journal_title：Experimental and molecular pathology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.yexmp.2004.04.005

    authors： Sinha AA,Quast BJ,Reddy PK,Lall V,Wilson MJ,Qian J,Bostwick DG

    更新日期：2004-10-01 00:00:00

  • Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance.

    abstract：OBJECTIVE:Annexins are a family of intracellular proteins that bind membrane phospholipids in a Ca(2+) concentration-dependent manner. Several annexins play important roles during tumor progression. However, little is known about the clinical implications and biological functions of Annexin A3 in breast cancer. METHOD...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.04.002

    authors： Zeng C,Ke Z,Song Y,Yao Y,Hu X,Zhang M,Li H,Yin J

    更新日期：2013-08-01 00:00:00

  • RAR and RXR expression by Kupffer cells.

    abstract：:Retinoids are known to modulate macrophage differentiation, proliferation, and function including cytokine gene expression. However, signaling of retinoic acid (RA), a biologically active metabolite of vitamin A, in Kupffer cells has not been characterized. This study reports mRNA expression by rat Kupffer cells of RA...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1999.2284

    authors： Ohata M,Yamauchi M,Takeda K,Toda G,Kamimura S,Motomura K,Xiong S,Tsukamoto H

    更新日期：2000-02-01 00:00:00

  • Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis.

    abstract：:Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.11.007

    authors： Schenkel AR,Chew TW,Chlipala E,Harbord MW,Muller WA

    更新日期：2006-08-01 00:00:00

  • Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients.

    abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years, which could be attributed to the high prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV), although HBV rates have declined af...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.09.012

    authors： Iyer P,Zekri AR,Hung CW,Schiefelbein E,Ismail K,Hablas A,Seifeldin IA,Soliman AS

    更新日期：2010-02-01 00:00:00

  • Biochemical effects of gentamicin on rat kidney cortex. II. Analytical subfractionation after short-term, high-dose treatment.

    abstract：:As a first step in studies on the molecular mechanism(s) underlying gentamicin toxicity, the effect of treating rats with this aminoglycoside antibiotic (100 mg/kg once or twice daily for 3 days) on the analytical subfractionation of the kidney cortex has been examined. DNA was used as a marker for the nuclei, cytochr...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(87)90068-2

    authors： Nässberger L,Bergstrand A,DePierre JW

    更新日期：1987-04-01 00:00:00

  • Expression and localization of the activated mitogen-activated protein kinase in lesional psoriatic skin.

    abstract：:Abnormalities in several signaling pathways and in the expression and/or activation of different transcription factors in psoriatic keratinocytes have been hypothesized to play a role in the pathophysiology of psoriasis. The mitogen-activated protein kinase (MAPK) cascades are among the best characterized of intracell...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.05.002

    authors： Yu XJ,Li CY,Dai HY,Cai DX,Wang KY,Xu YH,Chen LM,Zhou CL

    更新日期：2007-12-01 00:00:00

  • IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.

    abstract：OBJECTIVE:This study was designed to investigate whether IL-17 can regulate the expression of the MMP/TIMP system, the OPG/RANK/RANKL system, or type-I and type-III collagen fibers in a rat model of isoproterenol-induced heart failure (HF). We also investigated the effect of IL-17 on myocardial fibrosis in this model. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.06.001

    authors： Feng W,Li W,Liu W,Wang F,Li Y,Yan W

    更新日期：2009-12-01 00:00:00

  • Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease.

    abstract：:The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.03.007

    authors： Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

    更新日期：2005-10-01 00:00:00

  • The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis.

    abstract：:Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as t...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.12.001

    authors： Hu JM,Liu K,Liu JH,Jiang XL,Wang XL,Yang L,Chen YZ,Liu CX,Li SG,Cui XB,Zou H,Pang LJ,Zhao J,Qi Y,Liang WH,Yuan XL,Li F

    更新日期：2017-02-01 00:00:00

  • Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain.

    abstract：:The N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, is considered to have a close relationship to synaptic plasticity in the developing brain. In addition, it is known that the excessive stimulation of NMDARs can trigger neuronal apoptosis. In this study, we examined the distribution of...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00030-3

    authors： Takai H,Katayama K,Uetsuka K,Nakayama H,Doi K

    更新日期：2003-08-01 00:00:00

  • SFRP1 promotor methylation analysis of FTA card touch-prep samples derived from colonic polyps.

    abstract：:Whatman FTA® cards provide the most reliable method for DNA storage and extraction, however, the literature lacks reports on the epigenetic analysis of FTA card-derived tumor DNA. Therefore, this study aimed at demonstrating that punches from colonic adenoma samples preserved on FTA filter cards are suitable for methy...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104397

    authors： Buxhofer-Ausch V,Ausch C,Reiner A,Müllner-Ammer K,Schmid A,Kriwanek S,Sebesta C,Halwachs-Baumann G,Kriegshäuser G

    更新日期：2020-06-01 00:00:00

  • Maternal mosaicism underlies the inheritance of a rare germline AKT3 variant which is responsible for megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome in two Roma half-siblings.

    abstract：:Megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome is a developmental brain disorder characterized by an enlarged brain size with bilateral perisylvian polymicrogyria and a variable degree of ventriculomegaly. MPPH syndrome is associated with oromotor dysfunction, epilepsy, intellectual disability...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104471

    authors： Szalai R,Melegh BI,Till A,Ripszam R,Csabi G,Acharya A,Schrauwen I,Leal SM,Komoly S,Kosztolanyi G,Hadzsiev K

    更新日期：2020-08-01 00:00:00

  • LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122.

    abstract：BACKGROUND:Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been reported to be critical in the onset and progression of acute myocardial ischemia (AMI). This study attempted to reveal the biological function of MALAT1 in AMI. METHODS:Expression of MALAT1 in H9c2 cells was silenced by shRNA-mediated...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104325

    authors： Gong L,Chang H,Xu H

    更新日期：2019-12-01 00:00:00

  • Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro.

    abstract：:Recent studies have demonstrated important pro-inflammatory roles for two matrix metalloproteinases (MMPs)-MMP-3 (stromelysin-1) and MMP-9 (gelatinase B)-in acute lung injury [Am. J. Respir. Cell Mol. Biol. 24 (2001) 1]. A role for MMP-3 in skin inflammation has also been demonstrated [Proc. Natl. Acad. Sci. U. S. A. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.01.003

    authors： Warner RL,Bhagavathula N,Nerusu KC,Lateef H,Younkin E,Johnson KJ,Varani J

    更新日期：2004-06-01 00:00:00

  • Collagen metabolism in the myocardium of normal and diabetic rats.

    abstract：:Myocardial collagen and total protein synthesis were studied in normal, diabetic, and insulin-treated diabetic rats after a single intraperitoneal injection of L-[2,3-3H]proline as a radioisotopic precursor. The incorporation of tritiated proline into myocardial protein was regarded as a measure of total protein synth...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90060-3

    authors： Reddi AS

    更新日期：1988-04-01 00:00:00

  • Respiratory reovirus 1/L induction of diffuse alveolar damage: a model of acute respiratory distress syndrome.

    abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2001.2414

    authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

    更新日期：2002-02-01 00:00:00

  • Human umbilical cord mesenchymal stem cell-derived exosomes suppress dermal fibroblasts-myofibroblats transition via inhibiting the TGF-β1/Smad 2/3 signaling pathway.

    abstract：OBJECTIVE:Exosomes originated from mesenchymal stem cells (MSCs) benefit wound healing. This study investigated effects of exosomes originated from human umbilical cord MSCs (hUC-MSCs) on dermal fibroblasts-myofibroblasts transition via the TGF-β1/Smad2/3 signaling pathway. METHODS:Firstly, hUC-MSCs were collected and...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104468

    authors： Hu J,Chen Y,Huang Y,Su Y

    更新日期：2020-08-01 00:00:00

  • Effect of acute plasma fibronectin depletion on tissue fibronectin levels: analysis by a new fluorescent immunoassay.

    abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90010-8

    authors： Saba TM,Cho E,Blumenstock FA

    更新日期：1984-08-01 00:00:00

  • Effect of lead on the biological activity of calmodulin in rat brain.

    abstract：:In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The ad...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1026

    authors： Sandhir R,Gill KD

    更新日期：1994-08-01 00:00:00