Abstract：
:Platelet Endothelial Cell Adhesion Molecule (PECAM) is an adhesion and signaling molecule used for leukocyte extravasation. We have generated two strains of PECAM-deficient mouse, one in the original C57BL/6 and a second by backcrossing nice generations into the FVB/n strain. The FVB/n strain has reduced responses in models of acute inflammation. We show here that this strain is also susceptible to a chronic pneumonia which leads to pulmonary fibrosis. In contrast, PECAM-deficient C57BL/6 mice do not develop this lung disease and have normal responses in acute models of inflammation. This demonstrates that PECAM-dependent and -independent mechanisms are found in both acute and chronic inflammation. Further, the PECAM-deficient FVB/n strain has many pathologic similarities to the human disease Idiopathic Pulmonary Fibrosis, suggesting that similar molecular mechanisms may play a role in human disease.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Schenkel AR,Chew TW,Chlipala E,Harbord MW,Muller WAdoi
10.1016/j.yexmp.2005.11.007keywords:
subject
Has Abstractpub_date
2006-08-01 00:00:00pages
23-30issue
1eissn
0014-4800issn
1096-0945pii
S0014-4800(05)00144-9journal_volume
81pub_type
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journal_title：Experimental and molecular pathology
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更新日期：2007-12-01 00:00:00
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journal_title：Experimental and molecular pathology
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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journal_title：Experimental and molecular pathology
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...
journal_title：Experimental and molecular pathology
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更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Experimental and molecular pathology
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更新日期：1984-12-01 00:00:00
abstract：RATIONALE:The rat carotid balloon-injury (BI) model is a widely used model of intimal hyperplasia (IH) and vascular remodeling. A variable degree of IH after BI has been previously reported, and we have encountered technical challenges and suboptimal results with the original method. OBJECTIVE:To evaluate the original...
journal_title：Experimental and molecular pathology
pub_type： 杂志文章
doi：10.1016/j.yexmp.2011.06.011
更新日期：2011-10-01 00:00:00
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journal_title：Experimental and molecular pathology
pub_type： 杂志文章
doi：10.1016/j.yexmp.2014.08.005
更新日期：2014-10-01 00:00:00
