Human umbilical cord mesenchymal stem cell-derived exosomes suppress dermal fibroblasts-myofibroblats transition via inhibiting the TGF-β1/Smad 2/3 signaling pathway.

abstract：:Plasma fibronectin modulates reticuloendothelial (RE) phagocytosis of cellular and tissue debris, fibrin microaggregates, and gelatin-coated particulates. An antigenically related, but more insoluble form of fibronectin is found in various tissues and suspected to play a role in vascular permeability, cell adhesion, a...

journal_title：Experimental and molecular pathology

authors： Saba TM,Cho E,Blumenstock FA

更新日期：1984-08-01 00:00:00

abstract：:Endothelial cell activation and proliferation are the essential steps in flow-induced arterial remodeling. We investigated endothelial cell turnover in the early stages of high-flow in the rabbit common carotid arteries using an arteriovenous fistula (AVF) model by kinetic investigation of cell proliferation and cell ...

journal_title：Experimental and molecular pathology

authors： Sho E,Komatsu M,Sho M,Nanjo H,Singh TM,Xu C,Masuda H,Zarins CK

更新日期：2003-08-01 00:00:00

abstract：:During short term culture of murine resident peritoneal macrophages, increasing the temperature from 37 to 39 degrees C resulted in an increased activity of several surface receptors (FcR and receptor for gluteraldehyde-fixed sheep red blood cells), enhanced phagocytosis of yeast particles, improved spreading, and an ...

journal_title：Experimental and molecular pathology

authors： van Bruggen I,Robertson TA,Papadimitriou JM

更新日期：1991-10-01 00:00:00

abstract：:Spiroplasma spp. are important phyto and insect pathogens, and candidate causal agent/s of transmissible spongiform encephalopathies (TSE) in man and animals. These filterable wall-less bacteria are widely distributed in nature with an unspecified environmental reservoir. In this study we showed by scanning electron m...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Elzer PH,Wu X

更新日期：2012-08-01 00:00:00

abstract：:Several studies recognize cancer-stromal fibroblasts' role in cancer-cell invasion and metastasis. Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion ...

journal_title：Experimental and molecular pathology

authors： Chen H,Yang WW,Wen QT,Xu L,Chen M

更新日期：2009-12-01 00:00:00

abstract：:Dibasic esters (DBE) solvent has been demonstrated to induce a mild degeneration of the olfactory, but not the respiratory epithelium of the rat nasal cavity following a 90-day inhalation exposure. Previous work has demonstrated that acid phosphatase release is a reliable index of DBE-induced cytotoxicity in an in vit...

journal_title：Experimental and molecular pathology

authors： Trela BA,Frame SR,Bogdanffy MS

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The increased expression of the fibroblast growth factor receptor 4 (FGFR4) has been identified in many human cancers. Recently, a single nucleotide polymorphism changing the sense codon 388 from glycine to arginine was identified in the FGFR4 gene. The FGFR4 Arg(388) allele was found to be associated with a...

journal_title：Experimental and molecular pathology

authors： da Costa Andrade VC,Parise O Jr,Hors CP,de Melo Martins PC,Silva AP,Garicochea B

更新日期：2007-02-01 00:00:00

abstract：:Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent d...

journal_title：Experimental and molecular pathology

authors： Milićević Z,Slepcević V,Nikolić D,Zivanović V,Milićević NM

更新日期：1994-10-01 00:00:00

abstract：PURPOSE:Uterine leiomyomas (fibroids) are benign smooth muscle tumors commonly found among reproductive-aged women. Though benign, these tumors are the leading indication for hysterectomies in the United States and cause significant morbidity. Despite the importance of this tumor in women's health, relatively little is...

journal_title：Experimental and molecular pathology

authors： Meadows KL,Andrews DM,Xu Z,Carswell GK,Laughlin SK,Baird DD,Taylor JA

更新日期：2011-08-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer next to hepatocellular carcinoma (HCC). Despite the significant difference of the therapeutic strategy for both diseases, their histological appearance may be very similar. Thus the correct diagnosis is crucial for treatment choice bu...

journal_title：Experimental and molecular pathology

authors： Brychtova V,Zampachova V,Hrstka R,Fabian P,Novak J,Hermanova M,Vojtesek B

更新日期：2014-06-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Experimental and molecular pathology

authors： Wu N,Zhang X,Jia P,Jia D

更新日期：2015-05-07 00:00:00

abstract：:This ultrastructural investigation on renal collecting duct cells and hepatocytes of rats deals with the question of whether or not lipid-storage lysosomes as induced by cationic amphiphilic compounds retain their ability to fuse with autophagosomes/autolysosomes. These were recognized by their glycogen content which ...

journal_title：Experimental and molecular pathology

authors： Lüllmann-Rauch R,Watermann D

更新日期：1987-02-01 00:00:00

abstract：:This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic ste...

journal_title：Experimental and molecular pathology

authors： Neuman MG,French SW,French BA,Seitz HK,Cohen LB,Mueller S,Osna NA,Kharbanda KK,Seth D,Bautista A,Thompson KJ,McKillop IH,Kirpich IA,McClain CJ,Bataller R,Nanau RM,Voiculescu M,Opris M,Shen H,Tillman B,Li J,Liu H

更新日期：2014-12-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:Host immune status is an important determinant of disease progression. Infections in the genital tract may alter the immunity in the particular site and hence affect the production of local cytokines. We performed this study to determine whether HIV in association with cervical HPV and CT/GC infections influences the ...

journal_title：Experimental and molecular pathology

authors： Guha D,Chatterjee R

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS:Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and ...

journal_title：Experimental and molecular pathology

authors： El-Shazly SS,Hassan NM,Abdellateif MS,El Taweel MA,Abd-Elwahab N,Ebeid EN

更新日期：2019-10-01 00:00:00

abstract：:Plasmablastic lymphoma (PBL) is an uncommon aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extraoral sites, particularly extranodal sites, as well as in immunocompetent patients. We report an unusual case of PBL in a 69-year-old, HIV-neg...

journal_title：Experimental and molecular pathology

authors： Qing X,Sun N,Chang E,French S,Ji P,Yue C

更新日期：2011-02-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor im...

journal_title：Experimental and molecular pathology

authors： Sakiyama MJ,Espinoza I,Reddy A,de Carlo F,Kumar A,Levenson AS,Bae S,Zhou X,Claudio PP,Lewin J,Manucha V,Pound CR,Vijayakumar S,Gomez CR

更新日期：2019-06-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

journal_title：Experimental and molecular pathology

authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

更新日期：2016-04-01 00:00:00

abstract：:A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...

journal_title：Experimental and molecular pathology

authors： Chen X,Gong XL,Katsumata M,Zeng YT,Huang SZ,Zeng F

更新日期：2009-12-01 00:00:00

abstract：:The effects of chronic treatment with isoproterenol, reserpine, prenalterol, and terbutaline on rat parotid gland were investigated by electron microscopy and X-ray microanalysis. Chronic isoproterenol treatment induced lower potassium and calcium concentrations in the acinar cells. The cells were enlarged and contain...

journal_title：Experimental and molecular pathology

authors： Müller RM,Roomans GM

更新日期：1984-12-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefo...

journal_title：Experimental and molecular pathology

authors： de A Simão T,Souza-Santos PT,de Oliveira DS,Bernardo V,Lima SC,Rapozo DC,Kruel CD,Faria PA,Ribeiro Pinto LF,Albano RM

更新日期：2011-10-01 00:00:00

abstract：:The purpose of this work was to determine if mitochondrial dysfunction is involved in the development of non-alcoholic fatty liver disease (NAFLD). Using a model of obesity induced by the neonatal treatment of rats with monosodium L-glutamate (MSG), several parameters of liver mitochondrial function and their impact o...

journal_title：Experimental and molecular pathology

authors： Lazarin Mde O,Ishii-Iwamoto EL,Yamamoto NS,Constantin RP,Garcia RF,da Costa CE,Vitoriano Ade S,de Oliveira MC,Salgueiro-Pagadigorria CL

更新日期：2011-12-01 00:00:00

abstract：:The Chediak-Higashi syndrome (CHS) is an inherited disorder of humans and of several animal species, characterized by partial albinism, pseudohemophilia, increased susceptibility to disease, and large inclusions in all granule-forming cells. In this study, various parameters of adenine nucleotide biochemistry were exa...

journal_title：Experimental and molecular pathology

authors： Jamison KC,Padgett GA,Giesy JP,Bell TG

更新日期：1993-02-01 00:00:00

abstract：:The prognostic significance of selected markers of leukemic cells is well known. CD7 and CD56 expression at diagnosis has been associated with low remission rates and biological aggressiveness in a significant proportion of acute leukemias. Among 46 patients with acute myeloid leukemia, we found CD7 expression in 15 c...

journal_title：Experimental and molecular pathology

authors： Cruse JM,Lewis RE,Pierce S,Lam J,Tadros Y

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to investigate the relationship between the Apolipoprotein B/Apolipoprotein A 1 (ApoB/ApoA 1) ratio and various characteristics of the metabolic syndrome (MetS) in a sample of the Tunisian population. METHODS:The study included 330 adults aged 35-74 (172 patients with MetS and 158 c...

journal_title：Experimental and molecular pathology

authors： Belfki H,Ben Ali S,Bougatef S,Ben Ahmed D,Haddad N,Jmal A,Abdennebi M,Ben Romdhane H

更新日期：2011-10-01 00:00:00

abstract：:Smooth muscle cells from monkey aorta quiescent in 5% calf serum have been shown to be stimulated to renewed proliferation by hyperlipidemic serum or LDL from such serum. This proliferative response evidently is not dependent on platelet-derived growth factor present in our system in large quantities. The least exposu...

journal_title：Experimental and molecular pathology

authors： Mitsumata M,Fischer-Dzoga K,Getz GS,Wissler RW

更新日期：1988-02-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, is considered to have a close relationship to synaptic plasticity in the developing brain. In addition, it is known that the excessive stimulation of NMDARs can trigger neuronal apoptosis. In this study, we examined the distribution of...

journal_title：Experimental and molecular pathology

authors： Takai H,Katayama K,Uetsuka K,Nakayama H,Doi K

更新日期：2003-08-01 00:00:00

abstract：:A large surgical wound is required for implantation of silicone mammary devices. Formation of capsules around silicone devices follows wound healing processes except that the healing is conformed and significantly delayed by the physical presence of the implant. Multilayered capsules are thicker and lymphocytic and pl...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Smalley DL

更新日期：1999-09-01 00:00:00