当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > The Apolipoprotein B/Apolipoprotein A 1 ratio in relation to metabolic syndrome and its components in a sample of the Tunisian population.

The Apolipoprotein B/Apolipoprotein A 1 ratio in relation to metabolic syndrome and its components in a sample of the Tunisian population.

Abstract：

OBJECTIVE:This study was undertaken to investigate the relationship between the Apolipoprotein B/Apolipoprotein A 1 (ApoB/ApoA 1) ratio and various characteristics of the metabolic syndrome (MetS) in a sample of the Tunisian population. METHODS:The study included 330 adults aged 35-74 (172 patients with MetS and 158 controls). Waist circumference (WC), blood pressure (BP), HDL-cholesterol (HDL-C), triglycerides (TG), glucose, insulin, and apolipoprotein concentrations were measured. Homeostasis model assessment (HOMA) was used to assess insulin resistance (IR). MetS was defined by NCEP-ATPIII report. RESULTS:The ApoB/ApoA 1 ratio was significantly higher in patients with MetS versus normal control subjects (p<0.001). Mean values of ApoB/ApoA 1 ratio increased significantly as the numbers of MetS components increased in men (p<0.001) and women (p<0.001). ApoB/ApoA 1 ratio showed statistically significant associations with WC, HDL-C, TG, systolic and diastolic BP, and HOMA-IR. After adjusting for age and gender, the high ApoB/ApoA 1 ratio was significantly associated with the presence of MetS (odds ratio [OR]=6.10), IR (OR=1.88), and with each of the MetS components, including: high WC (OR=2.43), High TG (OR=6.14), and low HDL-C (OR=6.92). CONCLUSIONS:Our findings suggest that the ApoB/ApoA 1 ratio is strongly associated with MetS and its components, as well as with IR.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Belfki H,Ben Ali S,Bougatef S,Ben Ahmed D,Haddad N,Jmal A,Abdennebi M,Ben Romdhane H

doi

10.1016/j.yexmp.2011.06.007

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

622-5

issue

2

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(11)00090-6

journal_volume

91

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Experimental pulmonary fibrosis induced by paraquat plus oxygen in rats: a morphologic and biochemical sequential study.

    abstract：:Changes in lung structure and collagen metabolism were studied at 1, 2, 3, 4, 6, and 8 weeks in a model of pulmonary fibrosis induced in rats with paraquat plus hyperoxia. Morphologic examination of the lungs revealed that the earliest lesions consisted of severe and irreversible endothelial and alveolar epithelial ce...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(89)90027-0

    authors： Selman M,Montaño M,Ramos C,Barrios R,Pérez-Tamayo R

    更新日期：1989-04-01 00:00:00

  • Angiographic evaluation of the rat carotid balloon injury model.

    abstract：RATIONALE:The rat carotid balloon-injury (BI) model is a widely used model of intimal hyperplasia (IH) and vascular remodeling. A variable degree of IH after BI has been previously reported, and we have encountered technical challenges and suboptimal results with the original method. OBJECTIVE:To evaluate the original...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.06.011

    authors： Orozco LD,Liu H,Chen BB,Fratkin JD,Perkins E

    更新日期：2011-10-01 00:00:00

  • Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.

    abstract：:Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. Laboratory studies showed altered liver function and mild pancytopenia. Hepatitis...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.01.002

    authors： Peng Y,Cai J,Yue C,Qing X

    更新日期：2016-02-01 00:00:00

  • Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy.

    abstract：BACKGROUND:Calcific tendinopathy (CT) is characterized by deposits of calcium, most commonly found in the shoulder tendons. The exact cause and pathogenesis of CT are not fully understood. This study analyzed the expression pattern of RNA-binding protein fox-1 homolog 2 (RBFOX2), a crucial splicing regulator in tissue ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104264

    authors： Cho N,Kim JO,Lee S,Choi S,Kim J,Ko MS,Park SJ,Ji JH,Kim KK

    更新日期：2019-08-01 00:00:00

  • Co-expression of vascular and lymphatic endothelial cell markers on early endothelial cells present in aspirated coronary thrombi from patients with ST-elevation myocardial infarction.

    abstract：INTRODUCTION:Angiogenesis is the growth of both new vascular and lymphatic blood vessels from the existing vasculature. During this process, blood endothelial cells (BECs) and lymphatic endothelial cells (LECs) express specific markers, which help their discrimination and easier identification. Since the coronary throm...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.11.028

    authors： Rakocevic J,Kojic S,Orlic D,Stankovic G,Ostojic M,Petrovic O,Zaletel I,Puskas N,Todorovic V,Labudovic-Borovic M

    更新日期：2016-02-01 00:00:00

  • Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats.

    abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.08.016

    authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

    更新日期：2007-12-01 00:00:00

  • Maternal mosaicism underlies the inheritance of a rare germline AKT3 variant which is responsible for megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome in two Roma half-siblings.

    abstract：:Megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndrome is a developmental brain disorder characterized by an enlarged brain size with bilateral perisylvian polymicrogyria and a variable degree of ventriculomegaly. MPPH syndrome is associated with oromotor dysfunction, epilepsy, intellectual disability...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104471

    authors： Szalai R,Melegh BI,Till A,Ripszam R,Csabi G,Acharya A,Schrauwen I,Leal SM,Komoly S,Kosztolanyi G,Hadzsiev K

    更新日期：2020-08-01 00:00:00

  • RAR and RXR expression by Kupffer cells.

    abstract：:Retinoids are known to modulate macrophage differentiation, proliferation, and function including cytokine gene expression. However, signaling of retinoic acid (RA), a biologically active metabolite of vitamin A, in Kupffer cells has not been characterized. This study reports mRNA expression by rat Kupffer cells of RA...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1999.2284

    authors： Ohata M,Yamauchi M,Takeda K,Toda G,Kamimura S,Motomura K,Xiong S,Tsukamoto H

    更新日期：2000-02-01 00:00:00

  • Evaluation of formalin-free tissue fixation for RNA and microRNA studies.

    abstract：:FineFix, RCL-2 and HOPE, three formalin-free fixatives, were compared to the common used formalin fixed tissue samples of lung cancer and were evaluated for their effects on quality, quantity and integrity of RNA and microRNA. Two commercially available RNA extraction Kits (RNeasy FFPE by Qiagen and RecoverAll™ Nuclei...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.05.007

    authors： Arzt L,Kothmaier H,Quehenberger F,Halbwedl I,Wagner K,Maierhofer T,Popper HH

    更新日期：2011-10-01 00:00:00

  • The role of the peritoneal microenvironment in the pathogenesis of colorectal peritoneal carcinomatosis.

    abstract：:Recent insights have implicated mesothelial-to-mesenchymal transition (MMT) as a mechanism by which mesothelial cells can transdifferentiate into cancer-associated fibroblasts (CAFs) in several cancers metastasizing to the peritoneum. However, this was not evaluated extensively in colorectal cancer. We examined the pr...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104442

    authors： Demuytere J,Ceelen W,Van Dorpe J,Hoorens A

    更新日期：2020-08-01 00:00:00

  • The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia.

    abstract：:This study aimed to identify the expression of semaphorin 3C (SEMA3C) in the normal-metastatic spectrum of breast and oral cancers, and correlate expression with microvessel density (MVD, CD31), a surrogate marker of angiogenesis. Histological analysis revealed that SEMA3C expression was reduced in the development of ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.03.041

    authors： Cole-Healy Z,Vergani P,Hunter K,Brown NJ,Reed MW,Staton CA

    更新日期：2015-08-01 00:00:00

  • Sequential change of DNA synthesis in cultured aortic smooth muscle cells stimulated by hyperlipidemic serum.

    abstract：:Smooth muscle cells from monkey aorta quiescent in 5% calf serum have been shown to be stimulated to renewed proliferation by hyperlipidemic serum or LDL from such serum. This proliferative response evidently is not dependent on platelet-derived growth factor present in our system in large quantities. The least exposu...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90043-3

    authors： Mitsumata M,Fischer-Dzoga K,Getz GS,Wissler RW

    更新日期：1988-02-01 00:00:00

  • Absence of galectin-3 does not affect the development of experimental tongue carcinomas in mice.

    abstract：BACKGROUND:Galectin-3 is a lectin that presents pivotal roles in tumor biology and there are no studies evaluating their expression in dysplasias and carcinomas developed from tongue carcinogenesis models. AIMS:To investigate the role of galectin-3 in the development of tongue carcinomas using a mouse model of oral ca...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.12.007

    authors： de Faria PR,Chammas R,de Melo TL,Hsu DK,Liu FT,Nonogaki S,Cardoso SV,Loyola AM

    更新日期：2011-04-01 00:00:00

  • A new model of diffuse interstitial pulmonary fibrosis in the rat.

    abstract：:We have produced experimental diffuse interstitial pulmonary fibrosis in rats with a combination of low and repeated doses of paraquat plus continuous exposure to normobaric 74% O2 in the breathing air for several weeks. Pulmonary fibrosis was evaluated histologically and biochemically, through the determination of to...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90074-7

    authors： Selman M,Montaño M,Montfort I,Pérez-Tamayo R

    更新日期：1985-12-01 00:00:00

  • The role of cardiac fibroblasts in post-myocardial heart tissue repair.

    abstract：:The relative resistance of fibroblasts to hypoxia and their remarkable adaptive plasticity in response to rapid changes in local tissue microenvironment made interstitial cardiac fibroblasts to be a key player in post-myocardial infarction myocardial repair. Cardiac fibroblasts are abundantly presented in the intersti...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2016.09.002

    authors： Chistiakov DA,Orekhov AN,Bobryshev YV

    更新日期：2016-10-01 00:00:00

  • TNF signaling in vascular endothelial cells.

    abstract：:Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1006/exmp.2001.2368

    authors： Madge LA,Pober JS

    更新日期：2001-06-01 00:00:00

  • Ureaplasma in lung. 1. Localization by in situ hybridization in a mouse model.

    abstract：:Ureaplasma urealyticum is a common inhabitant of mucosal surfaces but is also associated with a higher incidence of pneumonia and bronchopulmonary dysplasia in preterm infants. Culture and polymerase chain reaction demonstrate high isolation rates of ureaplasma in clinical specimens documenting their presence but do n...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00051-0

    authors： Benstein BD,Crouse DT,Shanklin DR,Ourth DD

    更新日期：2003-10-01 00:00:00

  • Effect of carvedilol against myocardial injury due to ischemia-reperfusion of the brain in rats.

    abstract：:We have previously reported the mechanism behind the myocardial injury and the activation of autonomic nervous system during the ischemia-reperfusion (IR) of the rat brain. This study was planned to investigate the effect of carvedilol, a β-blocker, in improving the myocardial injury caused by IR of the rat brain. We ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.04.001

    authors： Harima M,Arumugam S,Wen J,Pitchaimani V,Karuppagounder V,Afrin MR,Sreedhar R,Miyashita S,Nomoto M,Ueno K,Nakamura M,Watanabe K

    更新日期：2015-06-01 00:00:00

  • Contradictory effects of short- and long-term hyperglycemias on ischemic injury of myocardium via intracellular signaling pathway.

    abstract：:Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction, there is disagreement about the sensitivity of ischemic injury of an infarcted myocardium in experimental studies. The present study evaluated the influences of different durations of hyperglycemia on ischemic and reperfusio...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2003.08.003

    authors： Xu G,Takashi E,Kudo M,Ishiwata T,Naito Z

    更新日期：2004-02-01 00:00:00

  • The effect of mild hyperthermia on the morphology and function of murine resident peritoneal macrophages.

    abstract：:During short term culture of murine resident peritoneal macrophages, increasing the temperature from 37 to 39 degrees C resulted in an increased activity of several surface receptors (FcR and receptor for gluteraldehyde-fixed sheep red blood cells), enhanced phagocytosis of yeast particles, improved spreading, and an ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(91)90047-2

    authors： van Bruggen I,Robertson TA,Papadimitriou JM

    更新日期：1991-10-01 00:00:00

  • Increased protein carbonylation of red blood cell membrane in diabetic retinopathy.

    abstract：:We investigated the protein carbonylation of red blood cell (RBC) membrane in type 2 diabetic patients and the potential implication of carbonyl/oxidative stress in reflecting disease severity. Sixty-four diabetic patients with or without retinopathy of variable clinical severity (Groups DR and DM, respectively) and 2...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.04.001

    authors： Margetis PI,Antonelou MH,Petropoulos IK,Margaritis LH,Papassideri IS

    更新日期：2009-08-01 00:00:00

  • Megakaryocytes and platelet homeostasis in diffuse alveolar damage.

    abstract：:Platelet homeostasis reflects a balance between the production of platelets via cytoplasmic fragmentation of megakaryocytes in the pulmonary microvasculature and their catabolism. Increased numbers of megakaryocytes are entrapped in the injured lung, potentially affecting circulating platelet counts. We enumerated pul...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.08.005

    authors： Mandal RV,Mark EJ,Kradin RL

    更新日期：2007-12-01 00:00:00

  • Methylation of tumor associated genes in tissue and plasma samples from liver disease patients.

    abstract：:To investigate whether aberrant hypermethylation in plasma DNA could be used as diagnosis makers for hepatocellular carcinoma (HCC), we performed methylation-specific PCR (MSP) to check the methylation status of five tumor associated genes in 36 cases of tissue and 42 cases of plasma samples from HCC and liver cirrhos...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2008.07.001

    authors： Chang H,Yi B,Li L,Zhang HY,Sun F,Dong SQ,Cao Y

    更新日期：2008-10-01 00:00:00

  • Pulmonary toxicity of cyclophosphamide: a 1-year study.

    abstract：:The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90031-0

    authors： Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

    更新日期：1985-04-01 00:00:00

  • Studies of adenine nucleotide biochemistry in the Chediak-Higashi syndrome.

    abstract：:The Chediak-Higashi syndrome (CHS) is an inherited disorder of humans and of several animal species, characterized by partial albinism, pseudohemophilia, increased susceptibility to disease, and large inclusions in all granule-forming cells. In this study, various parameters of adenine nucleotide biochemistry were exa...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1993.1004

    authors： Jamison KC,Padgett GA,Giesy JP,Bell TG

    更新日期：1993-02-01 00:00:00

  • miR-126 in human cancers: clinical roles and current perspectives.

    abstract：:miR-126 has been implicated in the processes of inflammation and angiogenesis. Through these processes, miR-126 is implicated in cancer biology, but its role there has not been well reviewed. The aim of this review is to examine the molecular mechanisms and clinicopathological significance of miR-126 in human cancers....

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2013.12.004

    authors： Ebrahimi F,Gopalan V,Smith RA,Lam AK

    更新日期：2014-02-01 00:00:00

  • Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells.

    abstract：:Lumican is a member of a small leucine-rich proteoglycan (SLRP) family and it regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues. Lumican expression was reported in various kinds of tumor cells. Lumican inhibits the growth of melanoma cells, but the lumican in pancrea...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.01.010

    authors： Ishiwata T,Yamamoto T,Kawahara K,Kawamoto Y,Matsuda Y,Ishiwata S,Naito Z

    更新日期：2010-06-01 00:00:00

  • Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3.

    abstract：:Antigen-specific CD8 suppressor T cells (CD8(+) Ts) are adaptive regulatory T cells that are induced in vivo and in vitro by chronic antigenic stimulation of human T cells. CD8(+) Ts induce the upregulation of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells rendering these antigen presenting ce...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.09.011

    authors： Vlad G,Suciu-Foca N

    更新日期：2012-12-01 00:00:00

  • Mechanisms of mallory body formation induced by okadaic acid in drug-primed mice.

    abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1998.2231

    authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

    更新日期：1998-10-01 00:00:00

  • Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders.

    abstract：:We cloned and partially characterized a human endonuclease (Xib) which shows sequence homologies to pancreatic DNase I but an enzymatic activity closer to DNase II. We report on the structural differences found between Xib and other recently cloned human DNases. Fluores cence microscopy analysis of transiently transfe...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1999.2254

    authors： Malferrari G,Mazza U,Tresoldi C,Rovida E,Nissim M,Mirabella M,Servidei S,Biunno I

    更新日期：1999-06-01 00:00:00