Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders.

abstract：:A primary culture of cells derived from uninvolved and atherosclerotic intima of human aorta was used to elucidate the role of cyclic nucleotides in atherogenesis. The cells cultured from fatty streaks and atherosclerotic plaques had a 2- to 8-fold lower cyclic AMP level and a 1.5- to 2-fold higher level of cyclic GMP...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Orekhov AN,Kudryashov SA,Klibanov AL,Ivanov NN,Torchilin VP,Smirnov VN

更新日期：1987-12-01 00:00:00

abstract：:The presence of immune cells is important for plaque destabilization. Disturbed flow conditions were shown to enhance the recruitment of circulating immune cells. Thus, we analyzed in 54 atherosclerotic carotid plaques the frequency of different immune cells, HLA-DR, chemokines, and chemokine receptors, comparing the ...

journal_title：Experimental and molecular pathology

authors： Yilmaz A,Lipfert B,Cicha I,Schubert K,Klein M,Raithel D,Daniel WG,Garlichs CD

更新日期：2007-06-01 00:00:00

abstract：:Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin....

journal_title：Experimental and molecular pathology

authors： Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami A

更新日期：2003-06-01 00:00:00

abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

journal_title：Experimental and molecular pathology

authors： Haywood S,Loughran M,Batt RM

更新日期：1985-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of this study was to investigate the effects of sulfasalazine (SASP) and its metabolites, sulfapyridine (SP), and 5-aminosalicylic acid (5ASA) on chemokine production b...

journal_title：Experimental and molecular pathology

authors： Volin MV,Campbell PL,Connors MA,Woodruff DC,Koch AE

更新日期：2002-10-01 00:00:00

abstract：:Recently it was observed that the hypothyroid state induced by propylthiouracil treatment reduced the elimination rate of ethanol. This was based on the fact that hypothyroid rats could only tolerate 10 g/kg/day of ethanol infusion over 24 h. Euthyroid rats tolerate 13 to 14 g/kg/day of ethanol infusion. In the presen...

journal_title：Experimental and molecular pathology

authors： Li J,French BA,Fu P,French SW

更新日期：2001-08-01 00:00:00

abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

journal_title：Experimental and molecular pathology

authors： Bastian FO,Dash S,Garry RF

更新日期：2004-08-01 00:00:00

abstract：:A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...

journal_title：Experimental and molecular pathology

authors： Chen X,Gong XL,Katsumata M,Zeng YT,Huang SZ,Zeng F

更新日期：2009-12-01 00:00:00

abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

journal_title：Experimental and molecular pathology

authors： Li H,Piao L,Xu D,Xuan Y

更新日期：2020-02-01 00:00:00

abstract：:A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminate...

journal_title：Experimental and molecular pathology

authors： Ye H,Wang Y,Yan J,Jenson AB

更新日期：2016-12-01 00:00:00

abstract：:As a first step in studies on the molecular mechanism(s) underlying gentamicin toxicity, the effect of treating rats with this aminoglycoside antibiotic (100 mg/kg once or twice daily for 3 days) on the analytical subfractionation of the kidney cortex has been examined. DNA was used as a marker for the nuclei, cytochr...

journal_title：Experimental and molecular pathology

authors： Nässberger L,Bergstrand A,DePierre JW

更新日期：1987-04-01 00:00:00

abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

journal_title：Experimental and molecular pathology

authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

更新日期：2001-02-01 00:00:00

abstract：:Thirty-nine patients with fibromyalgia syndrome (FMS) according to American College of Rheumatology criteria were studied for cell-mediated sensitivity to environmental chemicals. Lymphocytes were tested by standard [(3)H]thymidine incorporation in vitro for T cell memory to 11 chemical substances. Concanavalin A (Con...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Stevens MV,Hall MF,Smalley DL

更新日期：2000-10-01 00:00:00

abstract：:We have produced experimental diffuse interstitial pulmonary fibrosis in rats with a combination of low and repeated doses of paraquat plus continuous exposure to normobaric 74% O2 in the breathing air for several weeks. Pulmonary fibrosis was evaluated histologically and biochemically, through the determination of to...

journal_title：Experimental and molecular pathology

authors： Selman M,Montaño M,Montfort I,Pérez-Tamayo R

更新日期：1985-12-01 00:00:00

abstract：:The kynurenine pathway (KP) has a principal role in the metabolism of tryptophan. This pathway is also involved in the pathogenesis of cancer. We evaluated expression of two rate limiting enzymes from this pathway (IDO1 and TDO2) as well as three long non-coding RNAs (lncRNAs) that have been predicted to alter express...

journal_title：Experimental and molecular pathology

authors： Ghafouri-Fard S,Taherian-Esfahani Z,Dashti S,Kholghi Oskooei V,Taheri M,Samsami M

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Prostate cancer is the most common cancer in men. A Notch signaling pathway is an important pathway in cell proliferation, differentiation, and fate. However, currently, the effects of abiraterone based-anti-androgene therapy and docetaxel, the most commonly used standard chemotherapy in prostate cancer trea...

journal_title：Experimental and molecular pathology

authors： Soylu H,Kırca M,Avcı S,Ozpolat B,Ustunel I

更新日期：2021-01-19 00:00:00

abstract：:Ten cases of myopathy caused by glycogen storage diseases of type II, III, and V, and phosphorylase b kinase deficiency are reported. So-called "abnormal lysosomes" or glycogenosomes which contain abundant glycogen were found in cases of type II, and in some numbers, in cases of type III, and in one case of phosphoryl...

journal_title：Experimental and molecular pathology

authors： Iwamasa T,Fukuda S,Tokumitsu S,Ninomiya N,Matsuda I,Osame M

更新日期：1983-06-01 00:00:00

abstract：:The aim of this study was to evaluate if polymorphisms of APLN and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients. A case-control study was carried out including normotensive and hypertensive individuals. For these, two polymorphisms of APLN (rs3761581 and...

journal_title：Experimental and molecular pathology

authors： Esteban-Martínez RL,Pérez-Razo JC,Vargas-Alarcón G,Martínez-Rodríguez N,Cano-Martínez LJ,López-Hernández LB,Rojano-Mejía D,Canto P,Coral-Vazquez RM

更新日期：2016-08-01 00:00:00

abstract：:The most common recurrent translocation in clear cell sarcoma t(12;22)(q13;q12) results in an EWSR1/ATF1 chimeric gene. We present a molecular analysis of tumor overgrowing right proximal tibia with bone destruction metastatic to two groin lymph nodes. Fluorescent in situ hybridization analysis performed on paraffin-e...

journal_title：Experimental and molecular pathology

authors： Jakubauskas A,Valceckiene V,Andrekute K,Seinin D,Kanopka A,Griskevicius L

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:The rat carotid balloon-injury (BI) model is a widely used model of intimal hyperplasia (IH) and vascular remodeling. A variable degree of IH after BI has been previously reported, and we have encountered technical challenges and suboptimal results with the original method. OBJECTIVE:To evaluate the original...

journal_title：Experimental and molecular pathology

authors： Orozco LD,Liu H,Chen BB,Fratkin JD,Perkins E

更新日期：2011-10-01 00:00:00

abstract：OBJECT:Mutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing ...

journal_title：Experimental and molecular pathology

authors： Jha P,Suri V,Sharma V,Singh G,Sharma MC,Pathak P,Chosdol K,Jha P,Suri A,Mahapatra AK,Kale SS,Sarkar C

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to investigate the relationship between the Apolipoprotein B/Apolipoprotein A 1 (ApoB/ApoA 1) ratio and various characteristics of the metabolic syndrome (MetS) in a sample of the Tunisian population. METHODS:The study included 330 adults aged 35-74 (172 patients with MetS and 158 c...

journal_title：Experimental and molecular pathology

authors： Belfki H,Ben Ali S,Bougatef S,Ben Ahmed D,Haddad N,Jmal A,Abdennebi M,Ben Romdhane H

更新日期：2011-10-01 00:00:00

abstract：:A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

journal_title：Experimental and molecular pathology

authors： Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

更新日期：2014-12-01 00:00:00

abstract：:Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

journal_title：Experimental and molecular pathology

authors： Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

更新日期：2013-08-01 00:00:00

abstract：:Protection of intestinal graft mucosa during cold preservation is still an unmet need in clinical practice, thus affecting the success of transplantation. The present study investigates the ability of two ischemic preconditioning (IPC) procedures to limit cold preservation injury. Three groups of Sprague-Dawley rats w...

journal_title：Experimental and molecular pathology

authors： Jonecova Z,Toth S,Maretta M,Ciccocioppo R,Varga J,Rodrigo L,Kruzliak P

更新日期：2015-10-01 00:00:00

abstract：:Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioma. However, its role and molecular mechanism in glioma have not been completely elucidated. Immunohistochemistry analyses of EGFRvIII, enhancer of zeste homolog 2 (EZH2) and aplysia ras homolog I (ARHI) were p...

journal_title：Experimental and molecular pathology

authors： Zheng Y,Ma Y,Yue H,Liu G,Han S

更新日期：2020-02-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefo...

journal_title：Experimental and molecular pathology

authors： de A Simão T,Souza-Santos PT,de Oliveira DS,Bernardo V,Lima SC,Rapozo DC,Kruel CD,Faria PA,Ribeiro Pinto LF,Albano RM

更新日期：2011-10-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:Genes involved in the control of cell proliferation and survival (those genes most important to cancer pathogenesis) are often specifically regulated at the translational level, through RNA-protein interactions involving the 5'-untranslated region of the mRNA. IGF1R is a proto-oncogene strongly implicated in human bre...

journal_title：Experimental and molecular pathology

authors： Blume SW,Jackson NL,Frost AR,Grizzle WE,Shcherbakov OD,Choi H,Meng Z

更新日期：2010-06-01 00:00:00

abstract：:The effect of dichlorvos exposure (5 mg kg-1 body wt, ip) on lipid peroxidation and antioxidant defense system in different regions of the rat central nervous system was studied. In the present paper an inhibition of acetylcholinesterase activity was used as an index of dichlorvos neurotoxicity. We observed significan...

journal_title：Experimental and molecular pathology

authors： Julka D,Pal R,Gill KD

更新日期：1992-04-01 00:00:00