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A new model of diffuse interstitial pulmonary fibrosis in the rat.

Abstract：

:We have produced experimental diffuse interstitial pulmonary fibrosis in rats with a combination of low and repeated doses of paraquat plus continuous exposure to normobaric 74% O2 in the breathing air for several weeks. Pulmonary fibrosis was evaluated histologically and biochemically, through the determination of total collagen content in the lung. Our procedure is characterized by low initial mortality, the development of extensive distortion of the pulmonary architecture, and the presence of severe and diffuse interstitial fibrosis. The model was compared with bleomycin-induced pulmonary fibrosis in the same rat strain, in which the process is focal and leaves most of the lung unaffected. We conclude that lung damage produced by the combination of low doses of paraquat plus normobaric 74% O2 concentration in the breathing air is an adequate experimental model of diffuse interstitial pulmonary fibrosis as it occurs in many of the human cases of this condition.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Selman M,Montaño M,Montfort I,Pérez-Tamayo R

doi

10.1016/0014-4800(85)90074-7

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

375-87

issue

3

eissn

0014-4800

issn

1096-0945

pii

0014-4800(85)90074-7

journal_volume

43

pub_type

杂志文章

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