当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.

NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.

Abstract：

:Carbon tetrachloride-mediated loss of cytochrome P-450 has been compared in hepatic microsomes from untreated and phenobarbital-treated rats. At concentrations of carbon tetrachloride greater than 2.5 mM, a direct effect (i.e., NADPH- independent) on cytochrome P-450 was observed. This apparently arose from the "solvent" properties of carbon tetrachloride as this effect could be duplicated with the physically similar alkyl halide 1,2-dibromo-3-chloropropane. NADPH-dependent loss of cytochrome P-450 occurred at lower concentrations with maximal response occurring at 2.5-5.0 mM. Residual cytochrome P-450 at these concentrations was similar in untreated and phenobarbital-treated microsomes. Mixed-function oxidase activities in phenobarbital-treated microsomes were reduced to levels below those of uninduced controls. The 52-kDa polypeptide(s) in untreated microsomes and that specifically induced in phenobarbital-treated microsomes were susceptible to NADPH-dependent carbon tetrachloride incubation. These data suggest that the susceptibility of specific forms of cytochrome P-450 to carbon tetrachloride can be duplicated in in vitro incubation. Furthermore, data on the direct action of carbon tetrachloride suggest that this route of damage must be taken into consideration when concentrations of carbon tetrachloride of 2.5 mM or greater are used in in vitro incubation systems.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Moody DE,Head B,Woo CH,James JL,Smuckler EA

doi

10.1016/0014-4800(86)90045-6

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

318-28

issue

3

eissn

0014-4800

issn

1096-0945

pii

0014-4800(86)90045-6

journal_volume

44

pub_type

杂志文章

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