A study of endotoxin-associated hepatotoxicity on proliferating hepatocytes.

abstract：:We have previously shown that SIRT1 mRNA expression was significantly lower in relapsing MS patients compared to those in remission. Our goal was to longitudinally investigate the role of active, phosphorylated SIRT1 (p-SIRT1) as a potential biomarker of relapse and predictor for response to glatiramer acetate (GA) tr...

journal_title：Experimental and molecular pathology

authors： Ciriello J,Tatomir A,Hewes D,Boodhoo D,Anselmo F,Rus V,Rus H

更新日期：2018-10-01 00:00:00

abstract：:The keratinocyte growth factor (KGF) regulates cell growth and behavior in an autocrine or paracrine manner. In colorectal cancer tissues, KGF is expressed in tumor cells and adjacent stromal fibroblasts. We have constructed a KGF-gene-transfected cell line (HCT15-KGF) from a colorectal cancer cell line, HCT-15, that ...

journal_title：Experimental and molecular pathology

authors： Kudo M,Ishiwata T,Nakazawa N,Kawahara K,Fujii T,Teduka K,Naito Z

更新日期：2007-12-01 00:00:00

abstract：:Although clinical diabetes mellitus is obviously a high risk factor for myocardial infarction, there is disagreement about the sensitivity of ischemic injury of an infarcted myocardium in experimental studies. The present study evaluated the influences of different durations of hyperglycemia on ischemic and reperfusio...

journal_title：Experimental and molecular pathology

authors： Xu G,Takashi E,Kudo M,Ishiwata T,Naito Z

更新日期：2004-02-01 00:00:00

abstract：:Increased levels of prolactin (PRL) have recently been associated with carcinogenesis and the exacerbation of autoimmune diseases, and might be involved in the progression of tuberculosis (TB). To investigate the relationship between PRL and prolactin receptor (PRLr) expression with inflammatory response and apoptosis...

journal_title：Experimental and molecular pathology

authors： López-Rincón G,Mancilla R,Pereira-Suárez AL,Martínez-Neri PA,Ochoa-Zarzosa A,Muñoz-Valle JF,Estrada-Chávez C

更新日期：2015-06-01 00:00:00

abstract：:Kidney aging has been recognized as a chronic process of compromised renal function and structural changes in the tubulointerstitium and glomerulus. Cell senescence is associated with alterations in cell structure and function, including expression of cytokines and structural and regulatory components of extracellular...

journal_title：Experimental and molecular pathology

authors： Ding G,Franki N,Kapasi AA,Reddy K,Gibbons N,Singhal PC

更新日期：2001-02-01 00:00:00

abstract：:Certain biochemical parameters of acute liver injury induced by carbon tetrachloride were investigated in rats treated with prostacyclin (PGI2) and two of its derivatives. Serum glutamate oxalacetate transaminase elevation and both triglyceride accumulation and reduction of glycogen content in liver were significantly...

journal_title：Experimental and molecular pathology

authors： Divald A,Ujhelyi E,Jeney A,Lapis K,Institoris L

更新日期：1985-04-01 00:00:00

abstract：:Partial-thickness skin burns have been shown to induce neutrophil-dependent microvascular injury both locally (skin) and systemically (lung). In the present study, interventional measures to block inflammatory chemoattractants were employed to define the pathophysiologic role of these mediators in the development of s...

journal_title：Experimental and molecular pathology

authors： Piccolo MT,Wang Y,Sannomiya P,Piccolo NS,Piccolo MS,Hugli TE,Ward PA,Till GO

更新日期：1999-08-01 00:00:00

abstract：:An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

journal_title：Experimental and molecular pathology

authors： Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

更新日期：1989-06-01 00:00:00

abstract：:To understand the contribution of IL-6/IL-6R to subchondral bone and bone marrow abnormality in RA patients and the effects of tocilizumab on those abnormalities, we evaluated early change in a collagen-induced arthritis (CIA) monkey model with or without a single administration of tocilizumab. Six CIA cynomolgus monk...

journal_title：Experimental and molecular pathology

authors： Kato A,Matsuo S,Takai H,Uchiyama Y,Mihara M,Suzuki M

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Tumor surgery is aimed at complete resection of the lesion while ensuring a sufficient tumor-specific safety distance. Nevertheless, in many cases the most peripheral part - the invasion front - remains in situ. Tumor cells at the tumor margin have been reported to lose their epithelial properties and acquire f...

journal_title：Experimental and molecular pathology

authors： Alkatout I,Hübner F,Wenners A,Hedderich J,Wiedermann M,Sánchez C,Röcken C,Mathiak M,Maass N,Klapper W

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Tumor supressor gene FHIT was identified at chromosome 3p14.2 spanning the FRA3B fragile site and is very often inactivated in different types of cancer. The aim of this study was to examine the frequency of FHIT gene LOH as well as FHIT mRNA and protein expression in sporadic colon adenocarcinoma. METHODS:The...

journal_title：Experimental and molecular pathology

authors： Kapitanović S,Čačev T,Lončar B,Catela Ivković T,Križanac Š,Pavelić K

更新日期：2014-02-01 00:00:00

abstract：:Ameloblastoma is a benign odontogenic neoplasm that may exhibit aggressive biological behavior as evidenced by its rapid growth and significance recurrence rates following initial surgical resection. Currently, the only therapy for ameloblastoma is surgical, and adjunctive treatment modalities are needed to mitigate t...

journal_title：Experimental and molecular pathology

authors： Jhamb T,Kramer JM

更新日期：2014-12-01 00:00:00

abstract：:We have produced experimental diffuse interstitial pulmonary fibrosis in rats with a combination of low and repeated doses of paraquat plus continuous exposure to normobaric 74% O2 in the breathing air for several weeks. Pulmonary fibrosis was evaluated histologically and biochemically, through the determination of to...

journal_title：Experimental and molecular pathology

authors： Selman M,Montaño M,Montfort I,Pérez-Tamayo R

更新日期：1985-12-01 00:00:00

abstract：:The CXC chemokine receptor CXCR4 was the first molecule identified as a coreceptor working in conjunction with CD4 to mediate cellular entry for the human immunodeficiency virus (HIV-1). Since that original discovery, 11 other seven-mtransmembrane domain molecules, many of which are chemokine receptors, have been show...

journal_title：Experimental and molecular pathology

authors： van der Meer P,Ulrich AM,Gonźalez-Scarano F,Lavi E

更新日期：2000-12-01 00:00:00

abstract：:A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

journal_title：Experimental and molecular pathology

authors： Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

更新日期：2014-12-01 00:00:00

abstract：:Breast cancer (BC) is a major health problem for women around the world. Although advances in the field of molecular therapy have been achieved, the successful therapeutic management of BC, particularly metastatic disease, remains a challenge for patients and clinicians. One of the areas of current investigation is th...

journal_title：Experimental and molecular pathology

authors： Ejaeidi AA,Craft BS,Puneky LV,Lewis RE,Cruse JM

更新日期：2015-08-01 00:00:00

abstract：:During short term culture of murine resident peritoneal macrophages, increasing the temperature from 37 to 39 degrees C resulted in an increased activity of several surface receptors (FcR and receptor for gluteraldehyde-fixed sheep red blood cells), enhanced phagocytosis of yeast particles, improved spreading, and an ...

journal_title：Experimental and molecular pathology

authors： van Bruggen I,Robertson TA,Papadimitriou JM

更新日期：1991-10-01 00:00:00

abstract：:DNA isolated from the culture of an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus has been cloned. A region of the virus that contains genes coding proteins homologous to the UL141, UL144, and UL145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several dis...

journal_title：Experimental and molecular pathology

authors： Martin WJ

更新日期：1999-04-01 00:00:00

abstract：:Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

journal_title：Experimental and molecular pathology

authors： Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

更新日期：2013-08-01 00:00:00

abstract：:Thirty-nine patients with fibromyalgia syndrome (FMS) according to American College of Rheumatology criteria were studied for cell-mediated sensitivity to environmental chemicals. Lymphocytes were tested by standard [(3)H]thymidine incorporation in vitro for T cell memory to 11 chemical substances. Concanavalin A (Con...

journal_title：Experimental and molecular pathology

authors： Shanklin DR,Stevens MV,Hall MF,Smalley DL

更新日期：2000-10-01 00:00:00

abstract：:As a first step in studies on the molecular mechanism(s) underlying gentamicin toxicity, the effect of treating rats with this aminoglycoside antibiotic (100 mg/kg once or twice daily for 3 days) on the analytical subfractionation of the kidney cortex has been examined. DNA was used as a marker for the nuclei, cytochr...

journal_title：Experimental and molecular pathology

authors： Nässberger L,Bergstrand A,DePierre JW

更新日期：1987-04-01 00:00:00

abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...

journal_title：Experimental and molecular pathology

authors： McNulty SN,Schwetye K,Goldstein M,Carter J,Schmidt RE,Ansstas G,Tsien CI,Kim AH,Dahiya S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

journal_title：Experimental and molecular pathology

authors： Tian RH,Guo KM,Han GH,Bai Y

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:This study was undertaken to investigate the relationship between the Apolipoprotein B/Apolipoprotein A 1 (ApoB/ApoA 1) ratio and various characteristics of the metabolic syndrome (MetS) in a sample of the Tunisian population. METHODS:The study included 330 adults aged 35-74 (172 patients with MetS and 158 c...

journal_title：Experimental and molecular pathology

authors： Belfki H,Ben Ali S,Bougatef S,Ben Ahmed D,Haddad N,Jmal A,Abdennebi M,Ben Romdhane H

更新日期：2011-10-01 00:00:00

abstract：:Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been shown to ameliorate the clinical signs of EAE by suppressing the productio...

journal_title：Experimental and molecular pathology

authors： Liu N,Kan QC,Zhang XJ,Xv YM,Zhang S,Zhang GX,Zhu L

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

journal_title：Experimental and molecular pathology

authors： Chen P,Yan H,Chen Y,He Z

更新日期：2009-04-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

journal_title：Experimental and molecular pathology

authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

更新日期：2016-04-01 00:00:00

abstract：:As the fifth most common cancer and the second leading cause of cancer related deaths worldwide, hepatocellular carcinoma (HCC) causes up to one million deaths annually. Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are becoming the two major risk factors because both may develop liver fibro...

journal_title：Experimental and molecular pathology

authors： Jia Y,Ji P,French B,Tillman B,French SW

更新日期：2019-06-01 00:00:00

abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

journal_title：Experimental and molecular pathology

authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

更新日期：2011-02-01 00:00:00

abstract：:Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor im...

journal_title：Experimental and molecular pathology

authors： Sakiyama MJ,Espinoza I,Reddy A,de Carlo F,Kumar A,Levenson AS,Bae S,Zhou X,Claudio PP,Lewin J,Manucha V,Pound CR,Vijayakumar S,Gomez CR

更新日期：2019-06-01 00:00:00