The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.

abstract：:Although tumor surgery aims for a complete resection respecting tumor-specific safety distance, in many cases the most peripheral part, the invasion front, remains in situ. Tumor cells at the tumor margin lose epithelial properties and acquire features of mesenchymal cells. The process of epithelial-to-mesenchymal tra...

journal_title：Experimental and molecular pathology

authors： Alkatout I,Wiedermann M,Bauer M,Wenners A,Jonat W,Klapper W

更新日期：2013-02-01 00:00:00

abstract：:The effects of 2,5-hexanedione, the main metabolite of the solvents hexane and methyl butyl ketone, have been explored in different in vitro epithelial (CG5 and HEp-2) and melanoma (JR8) cells by means of immunochemistry and electron microscopy. The administration of the toxicant to the cell monolayers at noncytolytic...

journal_title：Experimental and molecular pathology

authors： Malorni W,Iosi F,Formisano G,Arancia G

更新日期：1989-02-01 00:00:00

abstract：:Granulomas, the pathologic hallmarks of tuberculosis, are composed of tightly numerous immune cells that respond to a variety of persistent stimuli during pathogen-host interaction. The granuloma is essential for host containment of mycobacterial infection, however, the mechanism of host and pathogen determinants to r...

journal_title：Experimental and molecular pathology

authors： Wang D,Zhou W,Lu S,Wang Q,Feng Y,Zhu G,Li L,Song Y,Gao Q

更新日期：2012-10-01 00:00:00

abstract：:Severed tendons can undergo regenerative healing, intrinsic tendon repair. Fibrillogenesis of chick tendon involves "collagen fibril segments" (CFS), which are the building blocks of collagen fibers that make up tendon fascicles. The CFS are 10.5 micron in length, composed of tropocollagen monomers arranged in paralle...

journal_title：Experimental and molecular pathology

authors： Hazard SW,Myers RL,Ehrlich HP

更新日期：2011-12-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have recently been recognized as the important regulators in cardiac diseases. This study was aimed to investigate the role and molecular mechanism of lncRNA KCNQ1OT1 in regulating cardiomyocyte apoptosis in heart failure (HF). The mouse model of HF was induced by doxorubicin (ADR). Cell ...

journal_title：Experimental and molecular pathology

authors： Lai L,Xu Y,Kang L,Yang J,Zhu G

更新日期：2020-08-01 00:00:00

abstract：:The purpose of this work was to determine if mitochondrial dysfunction is involved in the development of non-alcoholic fatty liver disease (NAFLD). Using a model of obesity induced by the neonatal treatment of rats with monosodium L-glutamate (MSG), several parameters of liver mitochondrial function and their impact o...

journal_title：Experimental and molecular pathology

authors： Lazarin Mde O,Ishii-Iwamoto EL,Yamamoto NS,Constantin RP,Garcia RF,da Costa CE,Vitoriano Ade S,de Oliveira MC,Salgueiro-Pagadigorria CL

更新日期：2011-12-01 00:00:00

abstract：:Drug-primed mice form Mallory bodies in their liver after various types of liver injury such as heat shock, drug refeeding, or ethanol ingestion. However, the mechanisms involved that lead to Mallory body formation after these different treatments are unknown. There may be a common pathway of Mallory body formation th...

journal_title：Experimental and molecular pathology

authors： Yuan QX,Nagao Y,Gaal K,Hu B,French SW

更新日期：1998-10-01 00:00:00

abstract：:Due to the ubiquitous nature of airborne endotoxin, an understanding of pulmonary alterations which follow inhalation of environmentally realistic concentrations of purified bacteria derived lipopolysaccharide (LPS) is important. Using LPS derived from Enterobacter agglomerans, a bacterium found in cotton and cotton m...

journal_title：Experimental and molecular pathology

authors： Lantz RC,Birch K,Hinton DE,Burrell R

更新日期：1985-12-01 00:00:00

abstract：:Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor in major and minor salivary glands (SGs). We have recently identified human cytomegalovirus (hCMV) as a principle component in the multifactorial causation of SG-MEC. This finding is corroborated by the ability of the purified mouse CMV (mCMV) to ind...

journal_title：Experimental and molecular pathology

authors： Melnick M,Deluca KA,Jaskoll T

更新日期：2014-08-01 00:00:00

abstract：:Although the extraction and analysis of nucleic acids from formalin-fixed paraffin-embedded tissues is a routine and growing part of pathology practice, no generally accepted recommendations exist to guide laboratories in their selection of tissue fixation, processing and DNA/RNA extraction techniques. The aim of this...

journal_title：Experimental and molecular pathology

authors： Turashvili G,Yang W,McKinney S,Kalloger S,Gale N,Ng Y,Chow K,Bell L,Lorette J,Carrier M,Luk M,Aparicio S,Huntsman D,Yip S

更新日期：2012-02-01 00:00:00

abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

journal_title：Experimental and molecular pathology

authors： Li H,Piao L,Xu D,Xuan Y

更新日期：2020-02-01 00:00:00

abstract：:In the present investigation, we observed that lead in vitro activates calmodulin at lower concentrations, and the maximum activation was observed at 30 microM concentration. In vivo lead exposure (50 mg/kg body weight, intragastrically) for a period of 8 weeks also stimulated the activity of calmodulin by 45%. The ad...

journal_title：Experimental and molecular pathology

authors： Sandhir R,Gill KD

更新日期：1994-08-01 00:00:00

abstract：:In this study we investigated the effects of a mild toxic challenge at selected points in time on the nonspecific cellular events that occurred in acutely damaged pulmonary alveoli. Swiss-Webster mice were treated with butylated hydroxytoluene (BHT, 400 mg/kg ip) and sacrificed at Days 1, 3, and 5 thereafter; either 2...

journal_title：Experimental and molecular pathology

authors： Coulombe PA,Lassonde G,Côté MG

更新日期：1987-10-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra. Recently, microRNAs (miRNAs) were emerging as important mediators in dopaminergic neuron biology. This study determined miR-410 expression in the 6-hydroxydopamine (6-OHDA)-induced in ...

journal_title：Experimental and molecular pathology

authors： Ge H,Yan Z,Zhu H,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:In the present study, BALB/c mice were used to develop a model for the hepatic injury associated to dengue infection. Histological analysis after subcutaneous inoculation with a low viral dose of dengue-2 virus showed Kupffer cell hyperplasia and an increased inflammatory cellular infiltrate next to the bile ducts on ...

journal_title：Experimental and molecular pathology

authors： França RF,Zucoloto S,da Fonseca BA

更新日期：2010-12-01 00:00:00

abstract：:Plasmodium yoelii infection in albino mice decreased the activity of brain glutamic acid decarboxylase (GAD) by about 30 and 48% in crude homogenate and its synaptosomal fraction, respectively. The decrease was evident from 20% parasitemia and remained more or less constant up to 80% parasitemia. The Km values of GAD ...

journal_title：Experimental and molecular pathology

authors： Sharma MC,Tripathi LM,Dutta GP,Sagar P,Pandey VC

更新日期：1990-04-01 00:00:00

abstract：:The purpose of the present study was to evaluate the relationship between class II major histocompatibility complex (MHC) genes (HLA-DR and HLA-DQB) and the genetic susceptibility to idiopathic dilated cardiomyopathy (IDC) in Mexican patients. The HLA-DR and DQB alleles were analyzed in 53 patients with IDC and 99 eth...

journal_title：Experimental and molecular pathology

authors： Rodríguez-Pérez JM,Fragoso JM,Alvarez-León E,Martínez-Rodríguez N,Gallardo GJ,Inés-Real S,Granados J,Reyes PA,Vargas-Alarcón G

更新日期：2007-02-01 00:00:00

abstract：:Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment. Molecular research is a hot topic in modern hospitals, and long non-coding RNA (LncRNA) has been ...

journal_title：Experimental and molecular pathology

authors： Li G,Du P,Qiang X,Jin D,Liu H,Li B,Guo J

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:New drugs targeting specific genes required for unregulated growth and metastases have improved survival rates for patients with metastatic colorectal cancer. Resistance to monoclonal antibodies specific for the epidermal growth factor receptor (EGFR) has been attributed to the presence of activating point m...

journal_title：Experimental and molecular pathology

authors： Perez K,Walsh R,Brilliant K,Noble L,Yakirevich E,Breese V,Jackson C,Chatterjee D,Pricolo V,Roth L,Shah N,Cataldo T,Safran H,Hixson D,Quesenberry P

更新日期：2013-08-01 00:00:00

abstract：:Pentraxins belong to the superfamily of conserved proteins that are characterized by a cyclic multimeric structure. Pentraxin 3 (PTX3) is a long pentraxin which can be produced by different cell types upon exposure to various inflammatory signals. Inside the neutrophil PTX3 is stored in form of granules localized in t...

journal_title：Experimental and molecular pathology

authors： Razvina O,Jiang S,Matsubara K,Ohashi R,Hasegawa G,Aoyama T,Daigo K,Kodama T,Hamakubo T,Naito M

更新日期：2015-02-01 00:00:00

abstract：:Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

journal_title：Experimental and molecular pathology

authors： Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

更新日期：1999-02-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is highly fatal due to late diagnosis and inefficient treatment. Early disease detection could improve diagnosis and patient survival. Esophageal squamous epithelial cells express SPRR3, a member of the small proline-rich protein family, which is downregulated in ESCC. Therefo...

journal_title：Experimental and molecular pathology

authors： de A Simão T,Souza-Santos PT,de Oliveira DS,Bernardo V,Lima SC,Rapozo DC,Kruel CD,Faria PA,Ribeiro Pinto LF,Albano RM

更新日期：2011-10-01 00:00:00

abstract：:The alterations, visible by light and electron microscopy, in the distal airway cells of Syrian golden hamsters were analyzed at several time intervals, from 6 hr to 4 weeks, after a single subcutaneous injection (120 mg/kg body wt) of 4-nitroquinoline 1-oxide (4NQO), a potent carcinogen. 4NQO induced injurious effect...

journal_title：Experimental and molecular pathology

authors： Ito T

更新日期：1985-04-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrial counties. Its pathogenesis is at least partially mediated by immunological factors, including a possible autoimmune response. To date, only a few antibodies have been identified in sera from patients with AMD. In order ...

journal_title：Experimental and molecular pathology

authors： Morohoshi K,Patel N,Ohbayashi M,Chong V,Grossniklaus HE,Bird AC,Ono SJ

更新日期：2012-02-01 00:00:00

abstract：:An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

journal_title：Experimental and molecular pathology

authors： Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:To identify the relationship between clinical pathological characteristics and the recurrence score (RS) on a 21-gene expression assay in patients with hormone receptor-positive, node-negative breast cancer, as well as the effect of RS on adjuvant decision-making. METHODS:The retrospective study was conducte...

journal_title：Experimental and molecular pathology

authors： Yu-Qing Y,Lei W,Mei-Ling H,Jing-Jing X,Mei-Chen W,Jiang W,Jun-Sheng H,Rui L,Nan-Lin L

更新日期：2019-06-01 00:00:00

abstract：:Rats were exposed to 12% O2 (1 atm) for 48 hr, then 10% O2 for the duration of the exposures. Significant elevations in enzymes of the glutathione peroxidase system were found in the lungs of rats killed 3.5, 7.5, and 12.5 days of exposure compared to air-breathing controls. Superoxide dismutase was also elevated afte...

journal_title：Experimental and molecular pathology

authors： Reddy AK,Kimball RE,Omaye ST

更新日期：1986-12-01 00:00:00

abstract：:The effect of chronic treatment with cystic fibrosis (CF) fibroblast medium on rat submandibular gland and pancreas was investigated. Rats were injected for 8 days with conditioned medium from normal or CF fibroblasts. The elemental content of the acinar cells was measured by X-ray microanalysis of cryosections. A sig...

journal_title：Experimental and molecular pathology

authors： von Euler AM,Ceder O,Kollberg H,Roomans GM

更新日期：1985-08-01 00:00:00

abstract：:Meningiomas are among the most common tumors of the adult central nervous system (CNS). They are classified by the World Health Organization into three pathologic grades with increasing severity: grade I are benign with favorable treatment outcomes and low recurrence rates while grade III display malignant behavior an...

journal_title：Experimental and molecular pathology

authors： McNulty SN,Schwetye K,Goldstein M,Carter J,Schmidt RE,Ansstas G,Tsien CI,Kim AH,Dahiya S

更新日期：2018-12-01 00:00:00

abstract：:Previous studies demonstrated that more electronegative low density lipoprotein (LDL) isolated from human blood by ion exchange chromatography has a chemical composition and physical properties similar to desialylated LDL obtained by lectin chromatography (Avogaro et al., 1988; Orekhov et al., 1989). In this study, si...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Bittolo-Bon G,Sobenin IA,Cazzolato G,Orekhov AN,Avogaro P

更新日期：1995-06-01 00:00:00