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Characterization of the anti-inflammation mechanism for the AO herbal extract.

Abstract：

:A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated. However, if the cause persists, it can lead to significant diseases. The pro-inflammatory cytokine TNFα is a biomarker for the inflammatory response. The AO herbal mixture extracted from 10 medicinal herbs has been investigated for its ability to control the inflammatory process and to inhibit TNFα activity. To find the treatment for inflammation related diseases, we examined whether the AO herbal extract is able to affect the activities of other cytokines. Here we present that the AO herbal extract is able to inhibit pro-inflammatory factor activities including IL-1α. However, it does not affect the activities of IL-1β and IL-6. Interestingly, it promotes the activity of anti-inflammatory factors including IL-4 and IL-13.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Ye H,Wang Y,Yan J,Jenson AB

doi

10.1016/j.yexmp.2016.11.005

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

341-345

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(16)30379-3

journal_volume

101

pub_type

杂志文章

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