当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Fibrosin: a novel lymphokine in wound healing.

Fibrosin: a novel lymphokine in wound healing.

Abstract：

:Several growth factors are actively synthesized during wound repair and function to stimulate different cell types involved in the process of healing. Fibrosin is a novel fibrogenic lymphokine that stimulates several biological activities that relate to in vivo scarring. To investigate the role of fibrosin, we used "punch biopsy" and linear wounding procedures in a murine model of wound healing. Histological examination showed that recombinant fibrosin stimulated epithelialization of wounds and accelerated healing of both punch biopsy and linear wounds. Fibrosin enhanced healing of linear wounds by reducing the time for healing by approximately 30-40%. From our data we estimated the healing time of control wounds to be 22-24 days; wounds treated with fibrosin appeared to heal in 14-16 days. Our observations suggest that fibrosin enhances wound healing and may be involved in accelerating epithelialization, collagen matrix formation, and also remodeling of the extracellular matrix in vivo. Thus fibrosin may function during different phases of wound healing and act as a potent inducer of scar formation and wound healing. This finding may have direct clinical applications.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Prakash S,Robbins PW

doi

10.1006/exmp.2001.2402

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

247-55

issue

3

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(01)92402-5

journal_volume

71

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Central nervous system (CNS) tumor cell heterogeneity contributes to differential platinum-based response in an in vitro 2D and 3D cell culture approach.

    abstract：:One of the models that best explains the cellular heterogeneity observed in central nervous system (CNS) tumors is the presence of cancer stem cells (CSCs). CSCs can originate from differentiated adult cells that return to an undifferentiated stage through the mechanism known as epithelial-mesenchymal transition (EMT)...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104520

    authors： Gonçalves BÔP,Fialho SL,Silvestrini BR,Sena IFG,Dos Santos GSP,Assis Gomes D,Silva LM

    更新日期：2020-10-01 00:00:00

  • Dysregulation of non-coding RNAs in autoimmune thyroid disease.

    abstract：:Autoimmune thyroid disease (AITD) is a complex disorder with both genetic and environmental risk factors. A number of genetic factors such as HLA and CTLA-4 loci have been associated with risk of this disorder. In addition to these factors, recent studies have shown contribution of non-coding RNAs in the pathogenesis ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2020.104527

    authors： Taheri M,Eghtedarian R,Dinger ME,Ghafouri-Fard S

    更新日期：2020-12-01 00:00:00

  • Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.

    abstract：:The kynurenine pathway (KP) has a principal role in the metabolism of tryptophan. This pathway is also involved in the pathogenesis of cancer. We evaluated expression of two rate limiting enzymes from this pathway (IDO1 and TDO2) as well as three long non-coding RNAs (lncRNAs) that have been predicted to alter express...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104415

    authors： Ghafouri-Fard S,Taherian-Esfahani Z,Dashti S,Kholghi Oskooei V,Taheri M,Samsami M

    更新日期：2020-06-01 00:00:00

  • The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis.

    abstract：:Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as t...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2016.12.001

    authors： Hu JM,Liu K,Liu JH,Jiang XL,Wang XL,Yang L,Chen YZ,Liu CX,Li SG,Cui XB,Zou H,Pang LJ,Zhao J,Qi Y,Liang WH,Yuan XL,Li F

    更新日期：2017-02-01 00:00:00

  • Low-expressed GAS5 injure myocardial cells and progression of chronic heart failure via regulation of miR-223-3P.

    abstract：:Chronic heart failure (CHF) is a common disease in clinical practice, and its incidence has been increasing in recent years. Understanding the pathogenesis of CHF is the key to its future clinical diagnosis and treatment. Molecular research is a hot topic in modern hospitals, and long non-coding RNA (LncRNA) has been ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104529

    authors： Li G,Du P,Qiang X,Jin D,Liu H,Li B,Guo J

    更新日期：2020-12-01 00:00:00

  • Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections.

    abstract：:The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections were used to prepare tissue arrays to examine the intensity of fluorescence of IHC stained stem cell markers in liver tissue from malignant HCC tumors and accompa...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.09.002

    authors： Buzzanco A,Gomez A,Rodriguez E,French BA,Tillman BA,Chang S,Ganapathy E,Junrungsee S,Zarrinpar A,Agopian VG,Naini BV,French SW Jr,French SW Sr

    更新日期：2014-12-01 00:00:00

  • The morphological development of glycol ether-induced testicular atrophy in the rat.

    abstract：:The testicular effects of daily oral dosing with two glycol ethers--either ethylene glycol monomethyl ether (EGM) or monoethyl ether (EGE) were studied in the prepubertal rat by histological examination of the testes. Over the 11-day dosing period studied, EGM was found to produce testicular damage at dose levels of a...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90074-1

    authors： Creasy DM,Foster PM

    更新日期：1984-04-01 00:00:00

  • Fibroblast activation protein-α promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms.

    abstract：:Fibroblast activation protein-α (FAPα) is secreted by activated stromal fibroblasts and can promote ovarian cancer cell proliferation, migration and invasion. However, the molecular mechanism by which FAPα promotes tumor cell proliferation and invasion is unknown. The role of the non-enzymatic activities of FAPα in tu...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.06.007

    authors： Yang W,Han W,Ye S,Liu D,Wu J,Liu H,Li C,Chen H

    更新日期：2013-08-01 00:00:00

  • Functional and morphological differences between human alveolar and interstitial macrophages.

    abstract：:Macrophages play an essential role in pulmonary host defense. They are, however, a heterogeneous cell population located in different lung compartments. This study was designed to elucidate differences between two macrophage populations obtained from the human lung, i.e., alveolar macrophages (AM) and interstitial mac...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2000.2344

    authors： Fathi M,Johansson A,Lundborg M,Orre L,Sköld CM,Camner P

    更新日期：2001-04-01 00:00:00

  • Role of RBM3 in the regulation of cell proliferation in hepatocellular carcinoma.

    abstract：:RNA binding motif protein 3 (RBM3) has been shown to be upregulated in several types of human tumors. Using tissue microarrays and immunohistochemistry, we showed here that both nuclear and cytoplasmic RBM3 expression levels were higher in hepatocellular carcinoma (HCC) tissues than in adjacent non-tumorous tissues. H...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104546

    authors： Miao X,Zhang N

    更新日期：2020-12-01 00:00:00

  • Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium L-glutamate in rats.

    abstract：:The purpose of this work was to determine if mitochondrial dysfunction is involved in the development of non-alcoholic fatty liver disease (NAFLD). Using a model of obesity induced by the neonatal treatment of rats with monosodium L-glutamate (MSG), several parameters of liver mitochondrial function and their impact o...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.07.003

    authors： Lazarin Mde O,Ishii-Iwamoto EL,Yamamoto NS,Constantin RP,Garcia RF,da Costa CE,Vitoriano Ade S,de Oliveira MC,Salgueiro-Pagadigorria CL

    更新日期：2011-12-01 00:00:00

  • The Apolipoprotein B/Apolipoprotein A 1 ratio in relation to metabolic syndrome and its components in a sample of the Tunisian population.

    abstract：OBJECTIVE:This study was undertaken to investigate the relationship between the Apolipoprotein B/Apolipoprotein A 1 (ApoB/ApoA 1) ratio and various characteristics of the metabolic syndrome (MetS) in a sample of the Tunisian population. METHODS:The study included 330 adults aged 35-74 (172 patients with MetS and 158 c...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.06.007

    authors： Belfki H,Ben Ali S,Bougatef S,Ben Ahmed D,Haddad N,Jmal A,Abdennebi M,Ben Romdhane H

    更新日期：2011-10-01 00:00:00

  • An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia.

    abstract：:The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90030-9

    authors： Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

    更新日期：1985-04-01 00:00:00

  • Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.

    abstract：:Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day). Diarrhea also occurred in monkeys after 1 week ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(83)90059-x

    authors： Yarrington JT,Sprinkle DJ,Loudy DE,Diekema KA,McCann PP,Gibson JP

    更新日期：1983-12-01 00:00:00

  • Glycosaminoglycans of normal and hypertrophic human scar.

    abstract：:The glycosaminoglycan (GAG) contents of hypertrophic scars, normal scars, and human skin from cadavers of matched ages were compared. Cellulose acetate electrophoresis, chondroitinase digestions, and reaction product and infrared analyses were used to characterize the component GAGs. DEAE-cellulose chromatography was ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90061-3

    authors： Donoff RB,Swann DA,Schweidt SH

    更新日期：1984-02-01 00:00:00

  • Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices.

    abstract：:The keratinocyte growth factor (KGF) regulates cell growth and behavior in an autocrine or paracrine manner. In colorectal cancer tissues, KGF is expressed in tumor cells and adjacent stromal fibroblasts. We have constructed a KGF-gene-transfected cell line (HCT15-KGF) from a colorectal cancer cell line, HCT-15, that ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.07.001

    authors： Kudo M,Ishiwata T,Nakazawa N,Kawahara K,Fujii T,Teduka K,Naito Z

    更新日期：2007-12-01 00:00:00

  • Macrophage degradation of LDL extracted from human aortic plaques: effect of isolation conditions.

    abstract：:Several laboratories have recently reported on the structural and functional characteristics of an LDL fraction isolated from atherosclerotic lesions, designated A-LDL. Given the wide variety of tissue sources and isolation conditions that have been employed, we have addressed whether several procedures currently used...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(91)90045-y

    authors： Hoff HF,O'Neil J,Cole TB

    更新日期：1991-02-01 00:00:00

  • Decreased humoral antibody episodes of acute renal allograft rejection in recipients expressing the HLA-DQβ1*0202 allele.

    abstract：:The present investigation was designed to show the effect of human leukocyte antigen (HLA) class II molecular allelic specificities in the recipient on the induction of humoral antibody rejection, identified by C4d peritubular capillary staining, as well as specific antibody identified by Luminex technology. Major his...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.05.005

    authors： Mannam VK,Santos M,Lewis RE,Cruse JM

    更新日期：2012-10-01 00:00:00

  • SFRP1 promotor methylation analysis of FTA card touch-prep samples derived from colonic polyps.

    abstract：:Whatman FTA® cards provide the most reliable method for DNA storage and extraction, however, the literature lacks reports on the epigenetic analysis of FTA card-derived tumor DNA. Therefore, this study aimed at demonstrating that punches from colonic adenoma samples preserved on FTA filter cards are suitable for methy...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104397

    authors： Buxhofer-Ausch V,Ausch C,Reiner A,Müllner-Ammer K,Schmid A,Kriwanek S,Sebesta C,Halwachs-Baumann G,Kriegshäuser G

    更新日期：2020-06-01 00:00:00

  • Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro.

    abstract：:Recent studies have demonstrated important pro-inflammatory roles for two matrix metalloproteinases (MMPs)-MMP-3 (stromelysin-1) and MMP-9 (gelatinase B)-in acute lung injury [Am. J. Respir. Cell Mol. Biol. 24 (2001) 1]. A role for MMP-3 in skin inflammation has also been demonstrated [Proc. Natl. Acad. Sci. U. S. A. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.01.003

    authors： Warner RL,Bhagavathula N,Nerusu KC,Lateef H,Younkin E,Johnson KJ,Varani J

    更新日期：2004-06-01 00:00:00

  • Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard.

    abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.03.002

    authors： Joseph LB,Heck DE,Cervelli JA,Composto GM,Babin MC,Casillas RP,Sinko PJ,Gerecke DR,Laskin DL,Laskin JD

    更新日期：2014-06-01 00:00:00

  • The role of cardiac fibroblasts in post-myocardial heart tissue repair.

    abstract：:The relative resistance of fibroblasts to hypoxia and their remarkable adaptive plasticity in response to rapid changes in local tissue microenvironment made interstitial cardiac fibroblasts to be a key player in post-myocardial infarction myocardial repair. Cardiac fibroblasts are abundantly presented in the intersti...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yexmp.2016.09.002

    authors： Chistiakov DA,Orekhov AN,Bobryshev YV

    更新日期：2016-10-01 00:00:00

  • Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES.

    abstract：:Genes involved in the control of cell proliferation and survival (those genes most important to cancer pathogenesis) are often specifically regulated at the translational level, through RNA-protein interactions involving the 5'-untranslated region of the mRNA. IGF1R is a proto-oncogene strongly implicated in human bre...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.03.006

    authors： Blume SW,Jackson NL,Frost AR,Grizzle WE,Shcherbakov OD,Choi H,Meng Z

    更新日期：2010-06-01 00:00:00

  • RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity.

    abstract：:Retinoids influence the pathogenesis of alcohol liver disease (ALD). To analyze the impact of retinoid X receptor alpha (RXRalpha) on ALD, alcohol-induced hepatotoxicity was studied using mice fed ethanol intragastrically for 25 days. Alcohol-induced microvesicular fat around the central vein and drug-induced morpholo...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/s0014-4800(03)00091-1

    authors： Dai T,Wu Y,Leng AS,Ao Y,Robel RC,Lu SC,French SW,Wan YJ

    更新日期：2003-12-01 00:00:00

  • The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.

    abstract：:Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of this study was to investigate the effects of sulfasalazine (SASP) and its metabolites, sulfapyridine (SP), and 5-aminosalicylic acid (5ASA) on chemokine production b...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2002.2460

    authors： Volin MV,Campbell PL,Connors MA,Woodruff DC,Koch AE

    更新日期：2002-10-01 00:00:00

  • Demonstrating collagen tendon fibril segments involvement in intrinsic tendon repair.

    abstract：:Severed tendons can undergo regenerative healing, intrinsic tendon repair. Fibrillogenesis of chick tendon involves "collagen fibril segments" (CFS), which are the building blocks of collagen fibers that make up tendon fascicles. The CFS are 10.5 micron in length, composed of tropocollagen monomers arranged in paralle...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.08.002

    authors： Hazard SW,Myers RL,Ehrlich HP

    更新日期：2011-12-01 00:00:00

  • Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma.

    abstract：PURPOSE:Tumor supressor gene FHIT was identified at chromosome 3p14.2 spanning the FRA3B fragile site and is very often inactivated in different types of cancer. The aim of this study was to examine the frequency of FHIT gene LOH as well as FHIT mRNA and protein expression in sporadic colon adenocarcinoma. METHODS:The...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.12.005

    authors： Kapitanović S,Čačev T,Lončar B,Catela Ivković T,Križanac Š,Pavelić K

    更新日期：2014-02-01 00:00:00

  • Effects of cis-diamminedichloroplatinum II (cisplatin) on the splenic tissue of rats: a histoquantitative study.

    abstract：:Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent d...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1027

    authors： Milićević Z,Slepcević V,Nikolić D,Zivanović V,Milićević NM

    更新日期：1994-10-01 00:00:00

  • Cytoskeletal changes induced in vitro by 2,5-hexanedione: an immunocytochemical study.

    abstract：:The effects of 2,5-hexanedione, the main metabolite of the solvents hexane and methyl butyl ketone, have been explored in different in vitro epithelial (CG5 and HEp-2) and melanoma (JR8) cells by means of immunochemistry and electron microscopy. The administration of the toxicant to the cell monolayers at noncytolytic...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(89)90056-7

    authors： Malorni W,Iosi F,Formisano G,Arancia G

    更新日期：1989-02-01 00:00:00

  • LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma.

    abstract：:Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is closely linked to the occurrence and development of many malignant tumors. Many studies have reported that enhanced expression of LETM1 in several types of human cancers was associated with poor clinical outcomes; however, its clinical significance i...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104333

    authors： Li H,Piao L,Xu D,Xuan Y

    更新日期：2020-02-01 00:00:00