Abstract:
:RNA binding motif protein 3 (RBM3) has been shown to be upregulated in several types of human tumors. Using tissue microarrays and immunohistochemistry, we showed here that both nuclear and cytoplasmic RBM3 expression levels were higher in hepatocellular carcinoma (HCC) tissues than in adjacent non-tumorous tissues. High nuclear RBM3 was found to be correlated with larger tumor size (P = 0.030), high serum AFP levels (P = 0.011), and advanced Edmonson grading (P = 0.006). Cytoplasmic RBM3 was associated with advanced Edmonson grading (P = 0.003). Kaplan-Meier survival analysis revealed that, although not statistically significant, there was a trend toward shortened overall survival in the subset of HCC patients with high RBM3 expression (both nuclear and cytoplasmic). In addition, we found that RBM3 could promote YAP1 expression in HCC cells. Moreover, we found that YAP1 played an essential part in RBM3-induced proliferation of HCC cells. Furthermore, we demonstrated that Verteporfin, a YAP1 inhibitor, could repress RBM3-induced proliferation of HCC cells. Our findings provide a new experimental basis for further understanding of the possible role of RBM3-YAP1 in the regulation of HCC proliferation.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Miao X,Zhang Ndoi
10.1016/j.yexmp.2020.104546subject
Has Abstractpub_date
2020-12-01 00:00:00pages
104546eissn
0014-4800issn
1096-0945pii
S0014-4800(20)30822-4journal_volume
117pub_type
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
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journal_title:Experimental and molecular pathology
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.yexmp.2011.01.002
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2011.03.001
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pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00