Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats.

abstract：:As the number of elderly patients increases, some patients with heart problems may also need surgery. The purpose of this study was to investigate whether dexmedetomidine (DEX), a common used anesthetic, was beneficial to the patients with heart problems. Myocardial cells induced by doxorubicin (DOX) was to simulate t...

journal_title：Experimental and molecular pathology

authors： He Y,Yang Z,Li J,Li E

更新日期：2020-04-01 00:00:00

abstract：:The parent-into-F1 mouse model (P-->F1) of acute graft-vs.-host disease (GVHD) is a useful model of human acute GVHD because it allows the study of the T cell contribution to pathology without the complicating effects of conditioning regimens. To determine the similarity of this model to human GVHD, we assessed injury...

journal_title：Experimental and molecular pathology

authors： Niculescu F,Niculescu T,Nguyen P,Puliaev R,Papadimitriou JC,Gaspari A,Rus H,Via CS

更新日期：2005-10-01 00:00:00

abstract：OBJECT:Mutations of the gene encoding isocitrate dehydrogenase (IDH) have been shown in a significant proportion of diffuse gliomas. These mutations are specific to gliomas and their utility for diagnosis and prognostication of these tumors is being proclaimed. The present study was conducted with the aim of assessing ...

journal_title：Experimental and molecular pathology

authors： Jha P,Suri V,Sharma V,Singh G,Sharma MC,Pathak P,Chosdol K,Jha P,Suri A,Mahapatra AK,Kale SS,Sarkar C

更新日期：2011-08-01 00:00:00

abstract：:Recent studies have demonstrated important pro-inflammatory roles for two matrix metalloproteinases (MMPs)-MMP-3 (stromelysin-1) and MMP-9 (gelatinase B)-in acute lung injury [Am. J. Respir. Cell Mol. Biol. 24 (2001) 1]. A role for MMP-3 in skin inflammation has also been demonstrated [Proc. Natl. Acad. Sci. U. S. A. ...

journal_title：Experimental and molecular pathology

authors： Warner RL,Bhagavathula N,Nerusu KC,Lateef H,Younkin E,Johnson KJ,Varani J

更新日期：2004-06-01 00:00:00

abstract：:The MHB-2 cell line, established from a mouse hepatoblastoma (HB), was subjected to the reverse transcriptase-polymerase chain reaction (RT-PCR) for evaluation of gene expression related to cell differentiation. RNAs for c-kit, CD34, thy-1, albumin, cytokeratin (CK) 8, 18 and 19 could be detected, but expression of al...

journal_title：Experimental and molecular pathology

authors： Sakairi T,Okada M,Ikeda I,Utsumi H,Kohge S,Sugimoto J,Sano F,Takagi S

更新日期：2007-12-01 00:00:00

abstract：:Lumican is a member of a small leucine-rich proteoglycan family. We previously found that lumican mRNA and its protein were ectopically and highly expressed in acinar cells in chronic pancreatitis (CP)-like lesions close to pancreatic cancer cells. CP-like lesions are characterized by acinar and ductal-ductular cell p...

journal_title：Experimental and molecular pathology

authors： Naito Z,Ishiwata T,Lu YP,Teduka K,Fujii T,Kawahara K,Sugisaki Y

更新日期：2003-02-01 00:00:00

abstract：:We previously reported that antibodies to squalene, an experimental vaccine adjuvant, are present in persons with symptoms consistent with Gulf War Syndrome (GWS) (P. B. Asa et al., Exp. Mol. Pathol 68, 196-197, 2000). The United States Department of Defense initiated the Anthrax Vaccine Immunization Program (AVIP) in...

journal_title：Experimental and molecular pathology

authors： Asa PB,Wilson RB,Garry RF

更新日期：2002-08-01 00:00:00

abstract：:The effect of dichlorvos exposure (5 mg kg-1 body wt, ip) on lipid peroxidation and antioxidant defense system in different regions of the rat central nervous system was studied. In the present paper an inhibition of acetylcholinesterase activity was used as an index of dichlorvos neurotoxicity. We observed significan...

journal_title：Experimental and molecular pathology

authors： Julka D,Pal R,Gill KD

更新日期：1992-04-01 00:00:00

abstract：:Macrophages play an essential role in pulmonary host defense. They are, however, a heterogeneous cell population located in different lung compartments. This study was designed to elucidate differences between two macrophage populations obtained from the human lung, i.e., alveolar macrophages (AM) and interstitial mac...

journal_title：Experimental and molecular pathology

authors： Fathi M,Johansson A,Lundborg M,Orre L,Sköld CM,Camner P

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

journal_title：Experimental and molecular pathology

authors： Tian RH,Guo KM,Han GH,Bai Y

更新日期：2020-08-01 00:00:00

abstract：:In the erythrocyte, ankyrin is the major adapter protein linking tetramers of band 3 to the spectrin-actin cytoskeleton. This linkage involves a direct interaction between ankyrin and the 14th-15th repeat unit of beta-spectrin. The spectrin cytoskeleton itself is stabilized by the self-association of spectrin heterodi...

journal_title：Experimental and molecular pathology

authors： Giorgi M,Cianci CD,Gallagher PG,Morrow JS

更新日期：2001-06-01 00:00:00

abstract：:The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and respon...

journal_title：Experimental and molecular pathology

authors： Nicol AF,Nuovo GJ,Wang Y,Grinsztejn B,Tristão A,Russomano F,Perez MA,Lapa e Silva JR,Fernandes AT,Gage JR,Martínez-Maza O,Bonecini-Almeida MG

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:New drugs targeting specific genes required for unregulated growth and metastases have improved survival rates for patients with metastatic colorectal cancer. Resistance to monoclonal antibodies specific for the epidermal growth factor receptor (EGFR) has been attributed to the presence of activating point m...

journal_title：Experimental and molecular pathology

authors： Perez K,Walsh R,Brilliant K,Noble L,Yakirevich E,Breese V,Jackson C,Chatterjee D,Pricolo V,Roth L,Shah N,Cataldo T,Safran H,Hixson D,Quesenberry P

更新日期：2013-08-01 00:00:00

abstract：:Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with ...

journal_title：Experimental and molecular pathology

authors： Karrasch T,Brünnler T,Hamer OW,Schmid K,Voelk M,Herfarth H,Buechler C

更新日期：2015-10-01 00:00:00

abstract：:Sulfur mustard (SM) is a bifunctional alkylating agent causing skin inflammation, edema and blistering. A hallmark of SM-induced toxicity is follicular and interfollicular epithelial damage. In the present studies we determined if SM-induced structural alterations in hair follicles and sebaceous glands were correlated...

journal_title：Experimental and molecular pathology

authors： Joseph LB,Heck DE,Cervelli JA,Composto GM,Babin MC,Casillas RP,Sinko PJ,Gerecke DR,Laskin DL,Laskin JD

更新日期：2014-06-01 00:00:00

abstract：:Sprague Dawley male rats (200-220 g) were subjected to a long-term treatment with low doses of catecholamines in an attempt to assess the effect of the adrenergic stimulation on ventricular weights, hemodynamics, and hydroxyproline content in the myocardium. Data are presented indicating that both exogenous catecholam...

journal_title：Experimental and molecular pathology

authors： Genovese A,Chiariello M,Bozzaotre M,Latte S,De Alfieri W,Condorelli M

更新日期：1984-12-01 00:00:00

abstract：:Vascular endothelium is a major target of actions of the proinflammatory cytokine tumor necrosis factor (TNF). Increasingly, the intracellular pathways that are activated in response to TNF have been elucidated. Many of these pathways have proven to be cell type-specific, requiring that observations made in other cell...

journal_title：Experimental and molecular pathology

authors： Madge LA,Pober JS

更新日期：2001-06-01 00:00:00

abstract：:Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk. A/J and SWR...

journal_title：Experimental and molecular pathology

authors： Delker DA,Wang QS,Papanikolaou A,Whiteley HE,Rosenberg DW

更新日期：1999-02-01 00:00:00

abstract：:The amelioration of fetal alcohol effects on the postnatal development of the Purkinje cell by exogenous L-thyroxine was investigated in the neonatal rat. Time-pregnant rats were divided into three groups. Group A (n = 6) received 35% liquid ethanol diet; Group B (n = 6) was fed a liquid diet in which maltose dextrins...

journal_title：Experimental and molecular pathology

authors： Nathaniel EJ,Hassard T,Burton L,Novak C

更新日期：1999-12-01 00:00:00

abstract：:Male rats fed a 3 g/kg copper diet were killed sequentially up to 14 weeks. Copper in liver and kidney cortex was identified histochemically and assayed in homogenates and gradient fractions following analytical subcellular fractionation on reorientating sucrose density gradients. Copper accumulated fastest in the liv...

journal_title：Experimental and molecular pathology

authors： Haywood S,Loughran M,Batt RM

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Pulmonary Adenocarcinoma with Enteric Differentiation (PAED) is a rare subtype of adenocarcinoma of emerging interest, recently introduced in the 2015 WHO classification. However, little is known about major molecular signatures of this class of adenocarcinomas and information about new biomarkers totally la...

journal_title：Experimental and molecular pathology

authors： Nottegar A,Tabbò F,Luchini C,Guerrera F,Gaudiano M,Bria E,Brunelli M,Chilosi M,Inghirami G

更新日期：2017-04-01 00:00:00

abstract：:Recent insights have implicated mesothelial-to-mesenchymal transition (MMT) as a mechanism by which mesothelial cells can transdifferentiate into cancer-associated fibroblasts (CAFs) in several cancers metastasizing to the peritoneum. However, this was not evaluated extensively in colorectal cancer. We examined the pr...

journal_title：Experimental and molecular pathology

authors： Demuytere J,Ceelen W,Van Dorpe J,Hoorens A

更新日期：2020-08-01 00:00:00

abstract：:Unilateral torsion of the spermatic cord was surgically induced in 24 Hartley strain guinea pigs. Groups of six animals were sacrificed 4, 8, 12, and 16 months after the surgery and testes were excised. Nine animals has severely damaged testes. Extensive study on the Sertoli cells of each of these nine animals was car...

journal_title：Experimental and molecular pathology

authors： Chakraborty J,Sinha Hikim AP,Jhunjhunwala JS

更新日期：1986-04-01 00:00:00

abstract：:Experimental autoimmune myositis (EAM) is a rodent model for human inflammatory muscle disease (IMD). It can be induced by immunization of rodents with skeletal muscle homogenate and adjuvant. The specific myositogenic autoantigen has not been clearly identified although some evidence points to skeletal muscle myosin....

journal_title：Experimental and molecular pathology

authors： Nemoto H,Bhopale MK,Constantinescu CS,Schotland D,Rostami A

更新日期：2003-06-01 00:00:00

abstract：:In our previous study, we demonstrated that a peptide derived from the novel centrosome residing protein Cep55/c10orf3 can be targeted by the cytotoxic T lymphocytes (CTLs) in peripheral blood mononuclear cells (PBMCs) of breast carcinoma patients. In this report, we evaluated the feasibility of cancer immunotherapy u...

journal_title：Experimental and molecular pathology

authors： Inoda S,Morita R,Hirohashi Y,Torigoe T,Asanuma H,Nakazawa E,Nakatsugawa M,Tamura Y,Kamiguchi K,Tsuruma T,Terui T,Ishitani K,Hashino S,Wang Q,Greene MI,Hasegawa T,Hirata K,Asaka M,Sato N

更新日期：2011-02-01 00:00:00

abstract：:A primary culture of cells derived from uninvolved and atherosclerotic intima of human aorta was used to elucidate the role of cyclic nucleotides in atherogenesis. The cells cultured from fatty streaks and atherosclerotic plaques had a 2- to 8-fold lower cyclic AMP level and a 1.5- to 2-fold higher level of cyclic GMP...

journal_title：Experimental and molecular pathology

authors： Tertov VV,Orekhov AN,Kudryashov SA,Klibanov AL,Ivanov NN,Torchilin VP,Smirnov VN

更新日期：1987-12-01 00:00:00

abstract：:The effects of 2,5-hexanedione, the main metabolite of the solvents hexane and methyl butyl ketone, have been explored in different in vitro epithelial (CG5 and HEp-2) and melanoma (JR8) cells by means of immunochemistry and electron microscopy. The administration of the toxicant to the cell monolayers at noncytolytic...

journal_title：Experimental and molecular pathology

authors： Malorni W,Iosi F,Formisano G,Arancia G

更新日期：1989-02-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is a clinical syndrome that is characterized by diffuse alveolar damage usually secondary to an intense host inflammatory response of the lung to a pulmonary or extrapulmonary infectious or noninfectious insult. In this report we describe a unique animal model in which CBA/J ...

journal_title：Experimental and molecular pathology

authors： London L,Majeski EI,Paintlia MK,Harley RA,London SD

更新日期：2002-02-01 00:00:00

abstract：:We have previously described the generation of a monoclonal antibody recognizing a novel cholangiocyte marker, designated BD.1, that is expressed by fetal and adult rat cholangiocytes but not hepatocytes or the hepatic progenitor cells known as oval cells. In the present report, we have undertaken a comprehensive exam...

journal_title：Experimental and molecular pathology

authors： Mills DR,Rozich RA,Flanagan DL,Brilliant KE,Yang D,Hixson DC

更新日期：2012-10-01 00:00:00

abstract：:In this comparative study, rat hearts were perfused at 37 degrees C with three clearly defined protocols: the Ca2+ paradox, the O(2) paradox, and with 20 mM caffeine. Each protocol involved an initial priming (Ca(2+)(0) depletion or anoxia; stage 1) and subsequent full activation (Ca(2+)(0) repletion, caffeine or reox...

journal_title：Experimental and molecular pathology

authors： Harding RJ,Duncan CJ

更新日期：1999-10-01 00:00:00