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In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women.

Abstract：

:The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and responsible for many aspects of both localized and systemic inflammatory responses. Further, expression of SSI/SOCS has been implicated in the negative feedback regulation of cytokine receptor signaling. PCR-amplified HIV-1 cDNA was noted mainly in the stroma, showing a perivascular distribution, and most of the infected cells colabeled with the macrophage marker CD68. The distribution of IL-6 and TNF-alpha was in the same area to HIV-1 and much greater than normal cervices from women with no evidence of viral infection. SOCS/SSI-1 and -3 mRNA positive cells in the uterine cervix were commonly detected in these noninfected cervical tissues; however, very few cells that contained SOCS were evident in areas where HIV-1, TNF-alpha, and IL-6 expressing cells were found. This suggests that viral-related suppression of SOCS/SSI-1-3 expression may be a factor in the marked local enhancement of TNF-alpha and IL-6 production which, in turn, may help facilitate viral spread; however, further studies should be done in order to elucidate the exact mechanisms of SOCS in the cervix.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Nicol AF,Nuovo GJ,Wang Y,Grinsztejn B,Tristão A,Russomano F,Perez MA,Lapa e Silva JR,Fernandes AT,Gage JR,Martínez-Maza O,Bonecini-Almeida MG

doi

10.1016/j.yexmp.2006.01.002

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

42-7

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(06)00009-8

journal_volume

81

pub_type

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