Naturally occurring modified low density lipoproteins are similar if not identical: more electronegative and desialylated lipoprotein subfractions.


:Previous studies demonstrated that more electronegative low density lipoprotein (LDL) isolated from human blood by ion exchange chromatography has a chemical composition and physical properties similar to desialylated LDL obtained by lectin chromatography (Avogaro et al., 1988; Orekhov et al., 1989). In this study, sialic acid content and percentage of desialylated LDL in the electronegative LDL (LDL-) subfraction have been investigated. The sialic acid content of the LDL- was 2- to 6-fold lower than that of native LDL and close to that of desialylated LDL. In the native LDL subfraction, 83% of lipoprotein particles did not bind to the Ricinus communis agglutinin, indicating lack of terminal galactose, presumably appearing as a result of desialylation of LDL carbohydrate chains. By contrast, a major proportion of human LDL- (81%) was bound to the lectin. It was also found that the desialylated LDL subfraction consists of 88% LDL-. Native LDL did not affect the contents of free and esterified cholesterol in intimal cells cultured from grossly normal human aorta, while LDL- and desialylated LDL induced a 1.5- to 3-fold increase in the intracellular content of cholesteryl esters. Thus, LDL- is desialylated LDL which induces lipid accumulation in intimal cells. Our findings suggest that the LDL- particle is similar if not identical to the desialylated LDL particle.


Exp Mol Pathol


Tertov VV,Bittolo-Bon G,Sobenin IA,Cazzolato G,Orekhov AN,Avogaro P




Has Abstract


1995-06-01 00:00:00














  • Pulmonary toxicity of cyclophosphamide: a 1-year study.

    abstract::The development of cyclophosphamide-induced pulmonary lesions over a 1-year period was studied in mice. Male BALB/c mice received a single intraperitoneal injection of 100 mg/kg of cyclophosphamide. Within 3 weeks there were scattered foci of intraalveolar foamy macrophages. With time, these foci increased in size and...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Morse CC,Sigler C,Lock S,Hakkinen PJ,Haschek WM,Witschi HP

    更新日期:1985-04-01 00:00:00

  • Enhanced expression of lumican inhibited the attachment and growth of human embryonic kidney 293 cells.

    abstract::Lumican is a member of a small leucine-rich proteoglycan (SLRP) family and it regulates the assembly and diameter of collagen fibers in the extracellular matrix of various tissues. Lumican expression was reported in various kinds of tumor cells. Lumican inhibits the growth of melanoma cells, but the lumican in pancrea...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Ishiwata T,Yamamoto T,Kawahara K,Kawamoto Y,Matsuda Y,Ishiwata S,Naito Z

    更新日期:2010-06-01 00:00:00

  • Delta-aminolevulinic dehydratase is a proteasome interacting protein.

    abstract::The proteasome interacts with a large number of proteins which regulate specific cellular functions. The focus of this study is to examine the proteasome interaction with Delta-aminolevulinate dehydratase (ALAD). ALAD is involved in the heme biosynthesis pathway and was co-isolated, with the 20S proteasome using sever...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Bardag-Gorce F,French SW

    更新日期:2011-10-01 00:00:00

  • The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.

    abstract:BACKGROUND:The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS:Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: El-Shazly SS,Hassan NM,Abdellateif MS,El Taweel MA,Abd-Elwahab N,Ebeid EN

    更新日期:2019-10-01 00:00:00

  • Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.

    abstract:BACKGROUND:Hypospadias, as a congenital disorder of the urethra, is the second most common birth abnormality of the male reproductive system. This study primarily investigates the effects of microRNA-494 (miR-494) on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway and on the development of hypospadia...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Tian RH,Guo KM,Han GH,Bai Y

    更新日期:2020-08-01 00:00:00

  • Glycosaminoglycans of normal and hypertrophic human scar.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Donoff RB,Swann DA,Schweidt SH

    更新日期:1984-02-01 00:00:00

  • Discovery of two novel EWSR1/ATF1 transcripts in four chimerical transcripts-expressing clear cell sarcoma and their quantitative evaluation.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Jakubauskas A,Valceckiene V,Andrekute K,Seinin D,Kanopka A,Griskevicius L

    更新日期:2011-04-01 00:00:00

  • Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.

    abstract::Growth and differentiation factor-5 (GDF-5) is a member of the TGF-ß superfamily which regulates cell division and differentiation. GDF-5 attracted high interest because of its role in skeletal development, especially in cartilaginous sites. Little is known, however, about the role of GFD-5 in disc cell biology. The p...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Gruber HE,Hoelscher GL,Ingram JA,Bethea S,Hanley EN Jr

    更新日期:2014-04-01 00:00:00

  • Isolation and characterization of crinosomes--a subclass of secondary lysosomes.

    abstract::A technique is presented for isolating a subclass of lysosomes, designated crinosomes, by one-step floating-up centrifugation in a cesium-containing sucrose gradient. Rats were treated with vinblastine in order to induce the formation of crinosomes. Vinblastine blocked exocytosis of secretory granules at the cell bord...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Glaumann H,Ahlberg J,Hultenby K,Jansson H,Mengarelli-Widholm S,Motakefi AM

    更新日期:1989-04-01 00:00:00

  • Cytochrome P450 isozyme distribution in normal and tumor-bearing hepatic tissue from rainbow trout (Salmo gairdneri).

    abstract::An immunohistochemical technique was used to localize the major constitutive cytochrome P450 isozyme, P450 LM2, and the major beta-naphthoflavone-inducible isozyme, P450 LM4b, in the livers of untreated and aflatoxin B1 (AFB1)-initiated, tumor-bearing rainbow trout. In hepatic tissue sections from untreated trout, no ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Lorenzana RM,Hedstrom OR,Gallagher JA,Buhler DR

    更新日期:1989-06-01 00:00:00

  • Hormone receptor-independent CXCL10 production is associated with the regulation of cellular factors linked to breast cancer progression and metastasis.

    abstract::Breast cancer (BC) is a major health problem for women around the world. Although advances in the field of molecular therapy have been achieved, the successful therapeutic management of BC, particularly metastatic disease, remains a challenge for patients and clinicians. One of the areas of current investigation is th...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Ejaeidi AA,Craft BS,Puneky LV,Lewis RE,Cruse JM

    更新日期:2015-08-01 00:00:00

  • Low-density lipoprotein endocytosis. II. Influence of the multivalent ligand cationized ferritin on acetylated low-density lipoprotein endocytosis in cultured cells.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Sprague EA,Edwards EH,Valente AJ,Suenram CA,Kerbacher JJ,Schwartz CJ

    更新日期:1988-06-01 00:00:00

  • Concordance of DNA methylation pattern in plasma and tumor DNA of Egyptian hepatocellular carcinoma patients.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer and the fourth leading cause of cancer mortality globally. HCC incidence has doubled in Egypt in the past 10 years, which could be attributed to the high prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV), although HBV rates have declined af...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Iyer P,Zekri AR,Hung CW,Schiefelbein E,Ismail K,Hablas A,Seifeldin IA,Soliman AS

    更新日期:2010-02-01 00:00:00

  • A BALB/c mouse model shows that liver involvement in dengue disease is immune-mediated.

    abstract::In the present study, BALB/c mice were used to develop a model for the hepatic injury associated to dengue infection. Histological analysis after subcutaneous inoculation with a low viral dose of dengue-2 virus showed Kupffer cell hyperplasia and an increased inflammatory cellular infiltrate next to the bile ducts on ...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: França RF,Zucoloto S,da Fonseca BA

    更新日期:2010-12-01 00:00:00

  • Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Warner RL,Bhagavathula N,Nerusu KC,Lateef H,Younkin E,Johnson KJ,Varani J

    更新日期:2004-06-01 00:00:00

  • Antiandrogen abiraterone and docetaxel treatments affect Notch1, Jagged1 and Hes1 expressions in metastatic prostate cancer cells.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Soylu H,Kırca M,Avcı S,Ozpolat B,Ustunel I

    更新日期:2021-01-19 00:00:00

  • The mechanisms of Mallory-Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders.

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    pub_type: 杂志文章,评审


    authors: French SW,Mendoza AS,Peng Y

    更新日期:2016-06-01 00:00:00

  • Eotaxin/CCL11 expression by infiltrating macrophages in rat heart transplants during ongoing acute rejection.

    abstract::Eotaxin/CCL11 chemokine is expressed in different organs, including the heart, but its precise cellular origin in the heart is unknown. Eotaxin is associated with Th2-like responses and exerts its chemotactic effect through the chemokine receptor-3 (CCR3), which is also expressed on mast cells (MC). The aim of our stu...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Zweifel M,Mueller C,Schaffner T,Dahinden C,Matozan K,Driscoll R,Mohacsi P

    更新日期:2009-10-01 00:00:00

  • The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Volin MV,Campbell PL,Connors MA,Woodruff DC,Koch AE

    更新日期:2002-10-01 00:00:00

  • Autologous bone marrow mesenchymal cell transplantation improves left ventricular function in a rabbit model of dilated cardiomyopathy.

    abstract:BACKGROUND:Bone marrow mesenchymal stem cells (BMSCs) could differentiate into cardiomyocytes. In this study, we wished to determine whether we could improve ventricular function in a dilated cardiomyopathy (DCM) model in the rabbit by injecting stem cells directly into the ventricular wall. METHODS AND RESULTS:Japane...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Chen Y,Liu W,Li W,Gao C

    更新日期:2010-04-01 00:00:00

  • RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Dai T,Wu Y,Leng AS,Ao Y,Robel RC,Lu SC,French SW,Wan YJ

    更新日期:2003-12-01 00:00:00

  • Restoration of chemosensitivity in cancer cells with MDR phenotype by deoxyribozyme, compared with ribozyme.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Xing AY,Shi DB,Liu W,Chen X,Sun YL,Wang X,Zhang JP,Gao P

    更新日期:2013-06-01 00:00:00

  • Effect of exogenous thyroxine on the development of the Purkinje cell in fetal alcohol effects in the rat.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Nathaniel EJ,Hassard T,Burton L,Novak C

    更新日期:1999-12-01 00:00:00

  • Polymorphisms of APLN-APLNR system are associated with essential hypertension in Mexican-Mestizo individuals.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Esteban-Martínez RL,Pérez-Razo JC,Vargas-Alarcón G,Martínez-Rodríguez N,Cano-Martínez LJ,López-Hernández LB,Rojano-Mejía D,Canto P,Coral-Vazquez RM

    更新日期:2016-08-01 00:00:00

  • Exponential relationship between plasma cholesterol levels and atherosclerotic lesion size in hyperlipidemic swine.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Schmee J,Kim DN,Ross JS,Thomas WA

    更新日期:1993-12-01 00:00:00

  • Effect of oxytocin on lipid accumulation under inflammatory conditions in human macrophages.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Karten A,Vernice NA,Renna HA,Carsons SE,DeLeon J,Pinkhasov A,Gomolin IH,Glass DS,Reiss AB,Kasselman LJ

    更新日期:2021-01-09 00:00:00

  • Acute sensitivity of BHT-induced alveolar toxicity to a diquat challenge in murine lungs.

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    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Coulombe PA,Lassonde G,Côté MG

    更新日期:1987-10-01 00:00:00

  • Human S-antigen: peptide determinant recognition in uveitis patients.

    abstract::Uveitis is an inflammation of the uveal tract and is one of the major causes of visual impairment. Several lines of evidence suggest an important role for activated T lymphocytes in the perpetuation of posterior uveitis. In sequel to our preliminary observations with human S-antigen, we have further investigated the p...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Tripathi P,Saxena S,Yadav VS,Naik S,Singh VK

    更新日期:2004-04-01 00:00:00

  • Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker.

    abstract::We studied the effects of clentiazem, a calcium channel blocker (1) on the accumulation of lipid in the aorta, (2) on the level of plasma lipids, and (3) on the number of adherent intimal monocytes and foam cells. Seventy Wistar rats were assigned to one of the following groups: (1) regular diet, (2) an atherogenic di...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Nunnari JJ,Fisher M,White SD

    更新日期:1992-12-01 00:00:00

  • Estrogen influence on maturational pathway of murine mammary tumor virus: an immunoelectron microscopy study.

    abstract::Modifications induced by estrogens on hormone-independent murine mammary tumor (MMT) and its main etiological agent, the MMT virus (MMTV), are reported. High doses of estrogens released continuously from silastic capsules delay significantly the development of transplanted tumors into syngeneic hosts. Neoplastic cells...

    journal_title:Experimental and molecular pathology

    pub_type: 杂志文章


    authors: Peralta Soler A,Aoki A

    更新日期:1989-02-01 00:00:00