Abstract:
:Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with disease activity. Admission levels of systemic sCD163 were nearly three-fold higher in patients with acute pancreatitis compared to controls. In patients sCD163 did not correlate with C-reactive protein and leukocyte count as established markers of inflammation. Levels were not associated with disease severity assessed by the Schroeder score, Balthazar score, Acute Physiology, Age, and Chronic Health Evaluation (Apache) II score and peripancreatic necrosis score. Soluble CD163 was not related to complications of acute pancreatitis. These data show that serum sCD163 is increased in acute pancreatitis indicating activation of macrophages but is not associated with disease severity and outcome.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Karrasch T,Brünnler T,Hamer OW,Schmid K,Voelk M,Herfarth H,Buechler Cdoi
10.1016/j.yexmp.2015.07.006subject
Has Abstractpub_date
2015-10-01 00:00:00pages
236-9issue
2eissn
0014-4800issn
1096-0945pii
S0014-4800(15)00154-9journal_volume
99pub_type
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pub_type: 杂志文章,收录出版
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doi:10.1016/j.yexmp.2004.10.008
更新日期:2005-06-01 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION AND AIMS:Oxytocin (OT) is a neuropeptide hormone secreted by the posterior pituitary gland. Deficits in OT action have been observed in patients with behavioral and mood disorders, some of which correlate with an increased risk of cardiovascular disease (CVD). Recent research has revealed a wider systemic ...
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journal_title:Experimental and molecular pathology
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更新日期:2014-12-01 00:00:00