Abstract:
:The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of stimulated, cultured human epidermis. HBD-2 was found to be stored in the lamellar bodies (LBs) of the stimulated keratinocytes of the spinous layer of the epidermis. HBD-2 was also found in the intercellular space. These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Oren A,Ganz T,Liu L,Meerloo Tdoi
10.1016/s0014-4800(02)00023-0keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
180-2issue
2eissn
0014-4800issn
1096-0945pii
S0014480002000230journal_volume
74pub_type
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