In human epidermis, beta-defensin 2 is packaged in lamellar bodies.

Abstract:

:The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of stimulated, cultured human epidermis. HBD-2 was found to be stored in the lamellar bodies (LBs) of the stimulated keratinocytes of the spinous layer of the epidermis. HBD-2 was also found in the intercellular space. These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances.

journal_name

Exp Mol Pathol

authors

Oren A,Ganz T,Liu L,Meerloo T

doi

10.1016/s0014-4800(02)00023-0

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

180-2

issue

2

eissn

0014-4800

issn

1096-0945

pii

S0014480002000230

journal_volume

74

pub_type

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