Abstract:
:The present study was addressed to understand two specific issues: (a) whether atherogenic activity of smooth muscle cells could be initiated by incorporating cholesterol within their membranes through a LDL-receptor-independent pathway; and (b) whether trifluoperazine, which we had recently shown to prevent the cholesterol-induced atherogenesis in an experimental animal model system, could prevent such activity of these cells induced by cholesterol in vitro. The results of such a study revealed that trifluoperazine could prevent the cholesterol-induced stimulation of (a) DNA synthesis, (b) cholesterol synthesis, (c) intracellular cGMP levels, (d) intracellular free and esterified cholesterol accumulation, and (e) collagen secretion. Furthermore, the drug caused stimulation of cholesterol-induced suppression of LDL-receptor synthesis. On this basis, we suggest that acquisition of cholesterol by smooth muscle cells through the LDL-receptor-independent pathway may be the fundamental process responsible for atherogenic activity of these cells and that the drug trifluoperazine has the inherent capacity to prevent the membrane-cholesterol-modulated atherogenic activity of smooth muscle cells in vitro.
journal_name
Exp Mol Patholjournal_title
Experimental and molecular pathologyauthors
Mehta U,Kaul Ddoi
10.1016/0014-4800(91)90014-okeywords:
subject
Has Abstractpub_date
1991-08-01 00:00:00pages
13-24issue
1eissn
0014-4800issn
1096-0945pii
0014-4800(91)90014-Ojournal_volume
55pub_type
杂志文章abstract::We examined the correlation between elastolysis and abnormal accumulation of microfibrils in the arteries of rabbits using light and electron microscopic and tissue culture techniques. Partial constriction of the common carotid arteries of rabbits gave rise to gradual atrophy of the media with elastolysis and an unusu...
journal_title:Experimental and molecular pathology
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doi:10.1016/0014-4800(90)90054-h
更新日期:1990-02-01 00:00:00
abstract::A novel intrauterine transplantation (IUT) approach was developed to improve the efficiency of engraftment of hematopoietic stem cells (HSCs). HSCs with a green fluorescent protein (GFP) reporter gene were transplanted in utero on days 12.5, 13.5 and 14.5 post coitum (p.c.). The degree of chimerism of donor cells in r...
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journal_title:Experimental and molecular pathology
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pub_type: 杂志文章,收录出版
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journal_title:Experimental and molecular pathology
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journal_title:Experimental and molecular pathology
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更新日期:2014-04-01 00:00:00
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更新日期:2011-12-01 00:00:00
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journal_title:Experimental and molecular pathology
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2011.01.002
更新日期:2011-06-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(92)90043-b
更新日期:1992-08-01 00:00:00
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journal_title:Experimental and molecular pathology
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journal_title:Experimental and molecular pathology
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更新日期:2014-10-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/j.yexmp.2009.04.001
更新日期:2009-08-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章,多中心研究
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更新日期:2015-12-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1006/exmp.2000.2346
更新日期:2001-02-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(83)90080-1
更新日期:1983-06-01 00:00:00
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journal_title:Experimental and molecular pathology
pub_type: 杂志文章
doi:10.1016/0014-4800(92)90031-6
更新日期:1992-04-01 00:00:00