当前位置： SCI文献检索 > EXPERIMENTAL AND MOLECULAR PATHOLOGY期刊下所有文献 > Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile.

Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile.

Abstract：

:Paraoxonase gene polymorphisms (PON1-55 and PON1-192) were determined in four Mexican populations (Mestizos, Nahuas, Teenek and Mayos) belonging to different ethnic groups. The role of these polymorphisms in the lipid profile in the Mestizo group was also analyzed. PON1 polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. Comparison among Mexican populations showed increased frequencies of PON1-55 L allele and LL genotype and decreased frequencies of M allele and LM genotype in the three Amerindian populations when compared to Mestizos (P < 0.05). Mexicans together with Asian populations (from Japan and China) presented the highest frequencies of PON1-55 L allele (P < 0.05 when compared to Caucasian populations). Heterogeneous data were noted when PON1-192 polymorphism comparison was made. In summary, distribution frequencies of PON1 showed that Mexican populations are more related to Asians than Caucasians. This confirms previous studies with other genetic markers indicating that Native Americans have stronger genetic affinities to the Paleolithic people of North-East Asia than to other major world populations. In Mexican Mestizos, lack of correlation between PON1 polymorphisms and lipid profile was found, corroborating previous data in other populations. The present data could be helpful to understand the distribution of these polymorphisms and its role as genetic and evolutive markers in the Amerindian populations.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Gamboa R,Zamora J,Rodríguez-Pérez JM,Fragoso JM,Cardoso G,Posadas-Romero C,Vargas-Alarcón G

doi

10.1016/j.yexmp.2005.05.006

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

85-90

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(05)00068-7

journal_volume

80

pub_type

杂志文章

相关文献

EXPERIMENTAL AND MOLECULAR PATHOLOGY文献大全
  • Low-density lipoprotein endocytosis. II. Influence of the multivalent ligand cationized ferritin on acetylated low-density lipoprotein endocytosis in cultured cells.

    abstract：:Interactions of the basic multivalent ligand cationized ferritin (CF) with cultured cells markedly alter their endocytic function. In this study, the influence of CF treatment on the binding, internalization, and degradation of chemically modified (acetylated) low-density lipoproteins (Ac-LDL) was examined in aortic s...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(88)90072-x

    authors： Sprague EA,Edwards EH,Valente AJ,Suenram CA,Kerbacher JJ,Schwartz CJ

    更新日期：1988-06-01 00:00:00

  • Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.

    abstract：:Subacute (2 week) oral or intravenous administration of DL-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), caused diarrhea and frequent emesis as early as 4 to 5 days in dogs (dose greater than or equal to 200 mg/kg/day). Diarrhea also occurred in monkeys after 1 week ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(83)90059-x

    authors： Yarrington JT,Sprinkle DJ,Loudy DE,Diekema KA,McCann PP,Gibson JP

    更新日期：1983-12-01 00:00:00

  • Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data.

    abstract：:Viral pathogens have been implicated in the development of certain cancers including human papillomavirus (HPV) in squamous cell carcinoma and Epstein-Barr virus (EBV) in Burkitt's lymphoma. The significance of viral pathogens in brain tumors is controversial, and human cytomegalovirus (HCMV) has been associated with ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.03.010

    authors： Cimino PJ,Zhao G,Wang D,Sehn JK,Lewis JS Jr,Duncavage EJ

    更新日期：2014-06-01 00:00:00

  • Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer.

    abstract：:The kynurenine pathway (KP) has a principal role in the metabolism of tryptophan. This pathway is also involved in the pathogenesis of cancer. We evaluated expression of two rate limiting enzymes from this pathway (IDO1 and TDO2) as well as three long non-coding RNAs (lncRNAs) that have been predicted to alter express...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104415

    authors： Ghafouri-Fard S,Taherian-Esfahani Z,Dashti S,Kholghi Oskooei V,Taheri M,Samsami M

    更新日期：2020-06-01 00:00:00

  • Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor.

    abstract：:Cell death caused by the accumulation of extracellular adenosine is believed to contribute to the profound loss of T lymphocytes in patients with severe combined immunodeficiency disease due to adenosine deaminase deficiency. Although adenosine is known to trigger apoptosis in thymocytes and peripheral T cells, the mo...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2005.08.001

    authors： El-Darahali A,Fawcett H,Mader JS,Conrad DM,Hoskin DW

    更新日期：2005-12-01 00:00:00

  • Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats.

    abstract：:The present study was aimed at clarifying the effects of an anti-apoptotic protein for modulating symptoms in acute lung injury (ALI). From Bcl-x(L), a Bcl-2 family member, we constructed an artificial protein (FNK) and fused it with the protein transduction domain (PTD) of the HIV/Tat protein (PTD-FNK) to facilitate ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.08.016

    authors： Chen H,Zhang L,Jin Z,Jin E,Fujiwara M,Ghazizadeh M,Asoh S,Ohta S,Kawanami O

    更新日期：2007-12-01 00:00:00

  • WITHDRAWN: Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosis.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.05.003

    authors： Wu N,Zhang X,Jia P,Jia D

    更新日期：2015-05-07 00:00:00

  • Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis.

    abstract：:We have analyzed the localization of dendritic cells (DCs) in non-lesional gray matter (NLGM) in comparison to non-lesional white matter (NLWM) and acute or chronic active multiple sclerosis (MS) lesions. Immunohistochemistry was performed on cryostat sections for DCs markers (CD209, CD205, CD83) and other markers for...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2007.05.006

    authors： Cudrici C,Ito T,Zafranskaia E,Niculescu F,Mullen KM,Vlaicu S,Judge SI,Calabresi PA,Rus H

    更新日期：2007-10-01 00:00:00

  • Differential gene expression profiling of cultured neu-transformed versus spontaneously-transformed rat cholangiocytes and of corresponding cholangiocarcinomas.

    abstract：:Previously, we described an orthotopic cholangiocarcinoma model based on bile duct inoculation of spontaneously-transformed low grade malignant rat BDE1 cholangiocytes (BDEsp cells) compared to high grade malignant erbB-2/neu- transformed BDE1 cholangiocytes (BDEneu cells) into the livers of syngeneic rats, which clos...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.08.007

    authors： Dumur CI,Campbell DJ,DeWitt JL,Oyesanya RA,Sirica AE

    更新日期：2010-12-01 00:00:00

  • Gene expression of tropoelastin is enhanced in the aorta proximal to the coarctation in rabbits.

    abstract：:To assess elastin biosynthesis in the aortic wall in response to acute elevation of blood pressure, we studied the aortic gene expression of tropoelastin in a rabbit midthoracic aortic coarctation model. The time points of the study were 1, 3, and 7 days and 2, 4, and 8 weeks after coarctation. Additional animals were...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.2002.2423

    authors： Xu C,Zarins CK,Glagov S

    更新日期：2002-04-01 00:00:00

  • SFRP1 promotor methylation analysis of FTA card touch-prep samples derived from colonic polyps.

    abstract：:Whatman FTA® cards provide the most reliable method for DNA storage and extraction, however, the literature lacks reports on the epigenetic analysis of FTA card-derived tumor DNA. Therefore, this study aimed at demonstrating that punches from colonic adenoma samples preserved on FTA filter cards are suitable for methy...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2020.104397

    authors： Buxhofer-Ausch V,Ausch C,Reiner A,Müllner-Ammer K,Schmid A,Kriwanek S,Sebesta C,Halwachs-Baumann G,Kriegshäuser G

    更新日期：2020-06-01 00:00:00

  • The role of β-catenin and paired-like homeobox 2B (PHOX2B) expression in neuroblastoma patients; predictive and prognostic value.

    abstract：BACKGROUND:The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers. METHODS:Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2019.104272

    authors： El-Shazly SS,Hassan NM,Abdellateif MS,El Taweel MA,Abd-Elwahab N,Ebeid EN

    更新日期：2019-10-01 00:00:00

  • The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats.

    abstract：OBJECTIVE:The aim of this study was to investigate the role and regulatory mechanisms of Akt/TSC1-TSC2/mTOR signal pathway on the hepatocyte growth and proliferation after partial hepatectomy in rats. METHODS:We used the animal model of 70% hepatectomy, separated and cultivated hepatocytes. According to the different ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.01.013

    authors： Chen P,Yan H,Chen Y,He Z

    更新日期：2009-04-01 00:00:00

  • Increased protein carbonylation of red blood cell membrane in diabetic retinopathy.

    abstract：:We investigated the protein carbonylation of red blood cell (RBC) membrane in type 2 diabetic patients and the potential implication of carbonyl/oxidative stress in reflecting disease severity. Sixty-four diabetic patients with or without retinopathy of variable clinical severity (Groups DR and DM, respectively) and 2...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2009.04.001

    authors： Margetis PI,Antonelou MH,Petropoulos IK,Margaritis LH,Papassideri IS

    更新日期：2009-08-01 00:00:00

  • An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia.

    abstract：:The effect of hypertension, hyperlipidemia, and the combination of both on acute and chronic myocardial ischemia were evaluated in a total of 30 male rabbits. After preliminary hypertension and/or hyperlipidemic load by loading of the abdominal aorta and/or cholesterol feeding, acute ischemia was produced by clipping ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(85)90030-9

    authors： Kuwao S,Kubo K,Kishimoto H,Mori N,Nishiyama Y

    更新日期：1985-04-01 00:00:00

  • Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver.

    abstract：:Chemerin is a recently described adipokine whose adipose tissue and serum levels are increased in obesity. Chemerin is expressed in the liver, and here, expression of chemerin has been studied in liver cells and in non-alcoholic fatty liver disease (NAFLD) which is more often found in obesity. Chemerin is shown to be ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2013.07.009

    authors： Krautbauer S,Wanninger J,Eisinger K,Hader Y,Beck M,Kopp A,Schmid A,Weiss TS,Dorn C,Buechler C

    更新日期：2013-10-01 00:00:00

  • Acute sensitivity of BHT-induced alveolar toxicity to a diquat challenge in murine lungs.

    abstract：:In this study we investigated the effects of a mild toxic challenge at selected points in time on the nonspecific cellular events that occurred in acutely damaged pulmonary alveoli. Swiss-Webster mice were treated with butylated hydroxytoluene (BHT, 400 mg/kg ip) and sacrificed at Days 1, 3, and 5 thereafter; either 2...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(87)90078-5

    authors： Coulombe PA,Lassonde G,Côté MG

    更新日期：1987-10-01 00:00:00

  • NADPH-dependent and -independent loss of cytochrome P-450 in control and phenobarbital-induced rat hepatic microsomes incubated with carbon tetrachloride.

    abstract：:Carbon tetrachloride-mediated loss of cytochrome P-450 has been compared in hepatic microsomes from untreated and phenobarbital-treated rats. At concentrations of carbon tetrachloride greater than 2.5 mM, a direct effect (i.e., NADPH- independent) on cytochrome P-450 was observed. This apparently arose from the "solve...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(86)90045-6

    authors： Moody DE,Head B,Woo CH,James JL,Smuckler EA

    更新日期：1986-06-01 00:00:00

  • Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.

    abstract：:Retinoblastoma (RB), the most common intra-ocular malignancy in children under 5 years of age, has an estimated incidence of about 2000 a year in India, where most cases are in advanced stage at the time of diagnosis. Newer therapeutic approaches would reduce the morbidity of chemotherapy in children with RB. Fatty Ac...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2010.11.007

    authors： Vandhana S,Deepa PR,Jayanthi U,Biswas J,Krishnakumar S

    更新日期：2011-02-01 00:00:00

  • Intercellular adhesion molecule-1 expression in experimental alcoholic liver disease: relationship to endotoxemia and TNF alpha messenger RNA.

    abstract：:We used the intragastric feeding rat model for alcoholic liver disease to evaluate the relationship among intercellular adhesion molecule-1 (ICAM-1) expression, tumor necrosis factor-alpha (TNF-alpha), plasma endotoxin, and inflammatory changes in the liver. Rats were fed different dietary fats (saturated fat, corn oi...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1995.1005

    authors： Nanji AA,Griniuviene B,Yacoub LK,Fogt F,Tahan SR

    更新日期：1995-02-01 00:00:00

  • Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium L-glutamate in rats.

    abstract：:The purpose of this work was to determine if mitochondrial dysfunction is involved in the development of non-alcoholic fatty liver disease (NAFLD). Using a model of obesity induced by the neonatal treatment of rats with monosodium L-glutamate (MSG), several parameters of liver mitochondrial function and their impact o...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2011.07.003

    authors： Lazarin Mde O,Ishii-Iwamoto EL,Yamamoto NS,Constantin RP,Garcia RF,da Costa CE,Vitoriano Ade S,de Oliveira MC,Salgueiro-Pagadigorria CL

    更新日期：2011-12-01 00:00:00

  • An Oct-1-based, feed-forward mechanism of apoptosis inhibited by co-culture with Raji B-cells: towards a model of the cancer cell/B-cell microenvironment.

    abstract：:A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2014.09.010

    authors： Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

    更新日期：2014-12-01 00:00:00

  • Early gene expression differences in inbred mouse strains with susceptibility to pulmonary adenomas.

    abstract：:Lung cancer is the most common cause of cancer-related deaths in both men and women, and effective preventatives are rare due to the difficulty of early detection. Specific gene expression signatures have been identified in individuals that already developed lung cancer. To identify if gene expression differences coul...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2012.09.015

    authors： Stearns TM,Cario CL,Savage HS,Sundberg JP,Paigen B,Berndt A

    更新日期：2012-12-01 00:00:00

  • In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women.

    abstract：:The purpose of this study was to look for associations between a newly described class of suppressors of cytokine signaling (SSI/SOCS) and cytokine expression in the uterine cervix from HIV/HPV coinfected women. We examined the pro-inflammatory cytokines TNF-alpha and IL-6 since their expressions are linked and respon...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2006.01.002

    authors： Nicol AF,Nuovo GJ,Wang Y,Grinsztejn B,Tristão A,Russomano F,Perez MA,Lapa e Silva JR,Fernandes AT,Gage JR,Martínez-Maza O,Bonecini-Almeida MG

    更新日期：2006-08-01 00:00:00

  • Increased expression of formin-like 3 contributes to metastasis and poor prognosis in colorectal carcinoma.

    abstract：:Formin-like 3 (FMNL3), a member of diaphanous-related formins subfamily, plays an important role in cytoskeleton reorganization, cell adhesion and cancer cell invasion in vitro. This study aimed to explore the expression of FMNL3 in colorectal carcinoma (CRC) cell-lines and tissues, and further evaluate its prognostic...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2015.03.008

    authors： Zeng YF,Xiao YS,Lu MZ,Luo XJ,Hu GZ,Deng KY,Wu XM,Xin HB

    更新日期：2015-04-01 00:00:00

  • Linking chronic wasting disease to scrapie by comparison of Spiroplasma mirum ribosomal DNA sequences.

    abstract：:Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative diseases of man and animals and are transmitted by a filterable pathogen whose identity is currently unresolved. Our data indicates that Spiroplasma, a wall-less bacterium, is involved in the pathogenesis of TSE. We searched for Spiroplasma ri...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/j.yexmp.2004.02.002

    authors： Bastian FO,Dash S,Garry RF

    更新日期：2004-08-01 00:00:00

  • Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma.

    abstract：:CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1994.1037

    authors： Figge J,del Rosario AD,Gerasimov G,Dedov I,Bronstein M,Troshina K,Alexandrova G,Kallakury BV,Bui HX,Bratslavsky G

    更新日期：1994-12-01 00:00:00

  • The pancreas in the degu.

    abstract：:Unique alpha-cell crystals, a herpes-like virus, islet amyloidosis, and immunohistochemical reactions of islets are compared in the rodent, Octodon degus, in animals with ordinary and high circulating glucose levels. Results suggest that crystals, virus, and amyloid are independent of blood sugar and bear no obvious r...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1016/0014-4800(84)90047-9

    authors： Spear GS,Caple MV,Sutherland LR

    更新日期：1984-06-01 00:00:00

  • Antibody protection in aging: influence of idiotypic repertoire and antibody binding activity to a bacterial antigen.

    abstract：:Previous studies demonstrated that the anti-phosphorylcholine (PC) antibodies produced by aged BALB/c (18-22 months old) mice are structurally different and less protective against infection with Streptococcus pneumoniae than those produced by young (3-4 months old) syngeneic mice. However, PC antibody from aged anima...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章

    doi：10.1006/exmp.1995.1011

    authors： Nicoletti C

    更新日期：1995-04-01 00:00:00

  • Ski diminishes TGF-β1-induced myofibroblast phenotype via up-regulating Meox2 expression.

    abstract：OBJECTIVE:The aim of the present work was to investigate the mechanism of transforming growth factor (TGF)-β1 and Sloan-Kettering Institute (Ski) in the pathogenesis of hypertrophic scars (HS). BACKGROUND:Wound healing is an inherent process, but the aberrant wound healing of skin injury may lead to HS. There has been...

    journal_title：Experimental and molecular pathology

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.yexmp.2014.11.002

    authors： Chen Z,Li W,Ning Y,Liu T,Shao J,Wang Y

    更新日期：2014-12-01 00:00:00