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Expression of hypoxia-inducible factor-1alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis.

Abstract：

:The hypoxia-inducible factor-1alpha (HIF-1alpha) is expressed in response to hypoxia and has been recently demonstrated in a variety of cells such as tumor cells and tumor-associated macrophages. Several characteristics of leishmanial lesions in humans and in animal models, such as microcirculation impairment, metabolic demand for leukocyte infiltration into infected tissue, parasite proliferation, and secondary bacterial infection, are strong indications of a hypoxic microenvironment in the lesions. We evaluated HIF-1alpha expression in the cutaneous lesions of BALB/c mice during Leishmania amazonensis infection. Immunohistochemical analyses of the lesions demonstrated, only in the later stages of infection when the lesion size is maximal and parasite burden is enormous and massive numbers of recruited macrophages and ulcers are observed, positive HIF-1alpha-infected cells throughout the lesions. HIF-1alpha is expressed mainly in the cytoplasm and around parasites inside the parasitophorous vacuoles of macrophages. This is the first evidence that macrophages in the microenvironment of lesions caused by a parasite produce a hypoxia-inducible factor.

journal_name

Exp Mol Pathol

journal_title

Experimental and molecular pathology

authors

Arrais-Silva WW,Paffaro VA Jr,Yamada AT,Giorgio S

doi

10.1016/j.yexmp.2004.09.002

keywords:

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

49-54

issue

1

eissn

0014-4800

issn

1096-0945

pii

S0014-4800(04)00091-7

journal_volume

78

pub_type

杂志文章

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